Paroxysmal Hypertension Associated With Urination

Lü, Ying; Lyu, Fan; Hou, Xiaopei; Dominiczak, Anna F.; Wang, Ji‐Guang; Staessen, Jan A.; Almustafa, Bader; Ching, SiewMooi; Persu, Alexandre; Bursztyn, Michael; Cai, Jun; Zhang, Huimin

doi:10.1161/hypertensionaha.119.13140

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…She presented with a more than 20-year history of headache, pallor in appearance, cold sweating, and palpitations within 1 to 2 minutes after urination. The above symptoms only lasted for a few minutes and then relieved spontaneously which is similar to the previously reported clinical manifestations of bladder PGL ( 38 , 39 ). Jove et al.…”

Section: Discussionsupporting

confidence: 89%

Bladder paraganglioma, gastrointestinal stromal tumor, and SDHB germline mutation in a patient with Carney-Stratakis syndrome: A case report and literature review

Shi

Ding²,

Mo³

et al. 2022

Front. Oncol.

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BackgroundCarney-Stratakis syndrome (CSS) is a rare dyad of paraganglioma (PGL)/pheochromocytoma (PHEO) and gastrointestinal stromal tumor (GIST). PGLs are neuroendocrine tumors of neural crest origin which are mostly found in the head, neck, and retroperitoneal space. GISTs are the most common mesenchymal tumors of the digestive tract, usually caused by KIT/PDGFRA mutations. Here, we reported a case of CSS with unusual bladder PGL and succinate dehydrogenase (SDH) deficient GIST due to a germline mutation in SDH-subunit B (SDHB) gene.Case presentationA 39-year-old female patient initially diagnosed with gastric GIST and isolated pelvic metastasis was eventually found to be CSS with bladder PGL and SDH-deficient GIST after surgery. This patient underwent resection of gastric and bladder tumors, and postoperative pathology confirmed the diagnosis of CSS. According to the next-generation sequencing (NGS), the patient carried a germline mutation in the SDHB gene, which was the cause of the disorder. The patient had no tumor recurrence with regular follow-up in 10 months.ConclusionsCSS is an autosomal genetic disorder with no gender difference in incidence, and PGLs are more frequent than GISTs. SDH germline mutation is the molecular biological mechanism of CSS while the most common type is SDHB mutation. The unique mechanism of tumorigenesis including hypoxia and hypermethylation caused by SDH deficiency renders target therapy with tyrosine kinase inhibitors ineffective, therefore complete surgical resection is the optimal treatment in the absence of tumor metastases.

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Section: Discussionsupporting

confidence: 89%

Bladder paraganglioma, gastrointestinal stromal tumor, and SDHB germline mutation in a patient with Carney-Stratakis syndrome: A case report and literature review

Shi

Ding²,

Mo³

et al. 2022

Front. Oncol.

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“…They can cause symptoms related to catecholamine release or mass effect. Symptoms such as palpitation, sweating, anxiety, paroxysmal hypertension may be seen due to adrenaline/noradrenaline release [6]. Our patient was nonsymptomatic.…”

Section: Discussionmentioning

confidence: 62%

The Paraganglioma of the Bladder in a Patient with Von Hippel-Lindau Syndrome

Dalar

2023

Asian Pac J Cancer Care

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Cardiac paraganglioma with sulfur subunit B gene mutation: a case report

Yang

Zhang

et al. 2021

European Heart Journal - Case Reports

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Background Pheochromocytoma and paraganglioma is a rare disease with a prevalence of 0.2–0.6% in hypertensive patients from outpatient. Case summary A 21-year-old man complained of blood pressure elevation over one year and persistent hyperhidrosis near 5 years. In local hospital, a mass in the pericardial space with abundant blood flow was observed via echocardiography and confirmed under minimally invasive thoracotomy. With suspicion of malignant cardiac mass, the patient was recommended to transfer for further diagnosis and treatment. Combining evaluation for blood and urinary catecholamine levels, somatostatin receptor imaging, and iodine-131 metaiodobenzylguanidine scintigraphy, he was confirmed with the diagnosis of cardiac paraganglioma with blood supply from the right coronary artery identified via angiography. The cardiac tumour was then surgically resected and confirmed with a pathological diagnosis of paraganglioma. Subsequent genetic test suggested succinate dehydrogenase complex iron sulfur subunit B (SDHB) gene mutation. At 5-month follow-up, the patient was recovered with normal levels of blood catecholamines and catecholamine metabolites. Discussion Cardiac paraganglioma should be considered and evaluated in hypertensive patients with cardiac mass, even in non-typical population. Given a potential risk of developing malignancies, close follow-up is significant in patients with SDHB gene mutations.

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Paroxysmal Hypertension Associated With Urination

Cited by 4 publications

References 17 publications

Bladder paraganglioma, gastrointestinal stromal tumor, and SDHB germline mutation in a patient with Carney-Stratakis syndrome: A case report and literature review

Bladder paraganglioma, gastrointestinal stromal tumor, and SDHB germline mutation in a patient with Carney-Stratakis syndrome: A case report and literature review

The Paraganglioma of the Bladder in a Patient with Von Hippel-Lindau Syndrome

Cardiac paraganglioma with sulfur subunit B gene mutation: a case report

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