Paroxysmal Cold Hemoglobinuria in a 4-year-old Child

Naithani, Rahul; Jeyaraman, Preethi; Saikia, Basanta; Dayal, Nitin; Pathak, Sangeeta

doi:10.1007/s13312-019-1618-z

Cited by 4 publications

(13 citation statements)

References 5 publications

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“…PCH is an intravascular hemolytic anemia mediated by inappropriate activation of the complement pathway. An IgG antibody attaches to the P antigen on RBCs at cool temperatures (for example, in acral areas) and when heated (when the blood returns to the core) leads to complement-mediated RBC lysis [5]. PCH is therefore known as a "biphasic" hemolytic Figure 2: Daily minimum hemoglobin throughout hospitalization.…”

Section: Discussionmentioning

confidence: 99%

“…anemia [1,[3][4][5][6]8]. PCH most commonly occurs in male children (male:female ratio 2.1 :1) around age 4-5 and follows a viral illness in 70% of cases [1,[4][5][6]9].…”

Section: Discussionmentioning

confidence: 99%

“…anemia [1,[3][4][5][6]8]. PCH most commonly occurs in male children (male:female ratio 2.1 :1) around age 4-5 and follows a viral illness in 70% of cases [1,[4][5][6]9]. Common viral infections implicated in triggering PCH include Epstein-Barr virus, cytomegalovirus, coxsackievirus, adenovirus, parvovirus, measles, mumps, varicella, or influenza [3][4][5].…”

Section: Discussionmentioning

confidence: 99%

“…Common viral infections implicated in triggering PCH include Epstein-Barr virus, cytomegalovirus, coxsackievirus, adenovirus, parvovirus, measles, mumps, varicella, or influenza [3][4][5]. Bacterial infections associated with PCH include Mycoplasma pneumoniae and Haemophilus influenzae [3,5]. PCH has also been known to follow childhood vaccination [6].…”

Section: Discussionmentioning

confidence: 99%

“…is disease process is typically self-resolving and rarely associated with severe renal injury requiring dialysis [1][2][3][4][5][6]7].…”

Section: Introductionmentioning

confidence: 99%

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A Case of Childhood Severe Paroxysmal Cold Hemoglobinuria with Acute Renal Failure Successfully Treated with Plasma Exchange and Eculizumab

Pelletier

Ward

Borloz

et al. 2022

Case Reports in Pediatrics

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We describe the case of a 4-year-old female who presented with sepsis and disseminated intravascular coagulation (DIC), developed ongoing intravascular hemolysis with acute renal failure from suspected pigment-induced acute tubular necrosis necessitating continuous renal replacement therapy (CRRT) for five days followed by four episodes of intermittent hemodialysis (iHD), and was subsequently diagnosed with paroxysmal cold hemoglobinuria (PCH). She was successfully treated with plasma exchange and eculizumab, a humanized monoclonal antibody targeting complement protein C5, and demonstrated significant improvement of hemolysis and recovery of renal function.

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Section: Discussionmentioning

confidence: 99%

“…anemia [1,[3][4][5][6]8]. PCH most commonly occurs in male children (male:female ratio 2.1 :1) around age 4-5 and follows a viral illness in 70% of cases [1,[4][5][6]9].…”

Section: Discussionmentioning

confidence: 99%