Paroxysmal cold hemoglobinuria in a child with RSV: an underrecognized cause of hemolytic anemia

Malave, Claritsa; Shardy, Deborah L.; Hartman, Sarah K.; Sampayo, Esther M.

doi:10.1016/j.ajem.2016.04.034

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…Certain viruses have been implicated in acute episodes of PCH in children, including measles, mumps, varicella, cytomegalovirus, EBV, influenza, parvovirus B19, coxsackievirus, and adenovirus. Only one other case report by Santos Malavé et al documents RSV causing PCH in a child [ 4 ]. To our knowledge, the case presented above is the first report of PCH triggered by RSV in an adult.…”

Section: Discussionmentioning

confidence: 99%

Paroxysmal Cold Hemoglobinuria in an Adult with Respiratory Syncytial Virus

Leibrandt

Angelino

Vizel-Schwartz

et al. 2018

Case Reports in Hematology

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Paroxysmal cold hemoglobinuria (PCH) is a rare form of cold autoimmune hemolytic anemia first discovered in the early 20th century in adults with tertiary syphilis. Today, it is more commonly seen in children as a life-threatening anemia during a viral upper respiratory tract infection (URI). Although respiratory syncytial virus (RSV) has previously been reported to cause PCH in a child, herein we present the first documented case in an adult. The Donath–Landsteiner (DL) test, the diagnostic test for PCH, was positive on two separate occasions. The patient was treated successfully with warming and avoidance of cold temperatures. To facilitate identification of this rare entity by clinicians, we include a discussion about the pathophysiology, diagnosis, and treatment of PCH.

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Section: Discussionmentioning

confidence: 99%

Paroxysmal Cold Hemoglobinuria in an Adult with Respiratory Syncytial Virus

Leibrandt

Angelino

Vizel-Schwartz

et al. 2018

Case Reports in Hematology

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“…The vast majority of cases are reported in children under 5 years of age after a viral infection, particularly with varicella, Epstein-Barr Virus (EBV), cytomegalovirus, adenovirus, respiratory syncytial virus, and influenza A virus. 3 Although in the past PCH was often associated with syphilis, more recent reports document that PCH occurs almost exclusively in young children after an acute viral illness. Many, but not all, reports document a male preponderance.…”

mentioning

confidence: 99%

“…Today, however, this disorder is rare in the adult population and when present is often associated with hematologic malignancies or other autoimmune disorders. The vast majority of cases are reported in children under 5 years of age after a viral infection, particularly with varicella, Epstein-Barr Virus (EBV), cytomegalovirus, adenovirus, respiratory syncytial virus, and influenza A virus 3 …”

mentioning

confidence: 99%

Epstein-Barr Virus-induced Paroxysmal Cold Hemoglobinuria in a 17-Year-old Male

Schmittau,

Giordano

2023

Journal of Pediatric Hematology/Oncology

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Paroxysmal cold hemoglobinuria is a rare autoimmune hemolytic anemia seen almost exclusively in children under 5 years of age after a viral illness. It is mediated by a biphasic polyclonal autoantibody against red blood cells, which causes severe hemolysis that typically self-resolves within 2 weeks without recurrence. While laboratory identification of the aforementioned antibody, the Donath Landsteiner antibody, would confirm this diagnosis, a negative test does not rule out this condition in the appropriate clinical context. We report on the rare occurrence of a severe presentation of paroxysmal cold hemoglobinuria in a 17-year-old male with Epstein-Barr virus infection.

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Paroxysmal cold hemoglobinuria in a child with RSV: an underrecognized cause of hemolytic anemia

Cited by 2 publications

References 8 publications

Paroxysmal Cold Hemoglobinuria in an Adult with Respiratory Syncytial Virus

Paroxysmal Cold Hemoglobinuria in an Adult with Respiratory Syncytial Virus

Epstein-Barr Virus-induced Paroxysmal Cold Hemoglobinuria in a 17-Year-old Male

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