Parotitis and Parainfluenza 3 Virus

Buckley, Jerome M.; Poche, Patricia; Mcintosh, Kenneth

doi:10.1001/archpedi.1972.02110170167033

Cited by 13 publications

(9 citation statements)

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“…HPIV-3 has been implicated in supraglottitis and bronchiolitis obliterans (120,285). HPIV parotitis has been diagnosed in otherwise healthy children infected with HPIV-1 and HPIV-3 (26,402), in immunocompromised children (381), and in a patient with cystic fibrosis (34). Croup caused by HPIV has been associated with bacterial tracheitis (83,218).…”

Section: Clinical Syndromesmentioning

confidence: 99%

Parainfluenza Viruses

2003

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Human parainfluenza viruses (HPIV) were first discovered in the late 1950s. Over the last decade, considerable knowledge about their molecular structure and function has been accumulated. This has led to significant changes in both the nomenclature and taxonomic relationships of these viruses. HPIV is genetically and antigenically divided into types 1 to 4. Further major subtypes of HPIV-4 (A and B) and subgroups/genotypes of HPIV-1 and HPIV-3 have been described. HPIV-1 to HPIV-3 are major causes of lower respiratory infections in infants, young children, the immunocompromised, the chronically ill, and the elderly. Each subtype can cause somewhat unique clinical diseases in different hosts. HPIV are enveloped and of medium size (150 to 250 nm), and their RNA genome is in the negative sense. These viruses belong to the Paramyxoviridae family, one of the largest and most rapidly growing groups of viruses causing significant human and veterinary disease. HPIV are closely related to recently discovered megamyxoviruses (Hendra and Nipah viruses) and metapneumovirus

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Section: Clinical Syndromesmentioning

confidence: 99%

Parainfluenza Viruses

2003

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“…Although mumps is generally regarded as a mild disease, its high morbidity and the relatively high rate of complications justify vaccination. Only about 50% of mumps infections are clinically apparent [Feldman, 19761, and other viral diseases may mimic the clinical picture of mumps [Zollar and Mufson, 1970;Buckley et al, 1972;Biedel, 19781. Serologic surveys to define the need for immunization, to confirm history of immunization and disease, and to ensure that adequate levels of antibodies have been induced by the vaccine are therefore required for a successful vaccination policy.…”

Section: Introductionmentioning

confidence: 99%

Antibody response after application of a new live attenuated mumps vaccine (Pariorix®) measured by enzyme‐linked immunosorbent assay (ELISA)

Popow‐Kraupp

Künz

Hofmann

1982

Journal of Medical Virology

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Mumps virus specific antibody concentrations were determined by enzyme-linked immunosorbent assay (ELISA), hemolysis-in-gel (HIG) test, and hemagglutination-inhibition (HI) test in 17 adult volunteers before and after vaccination with a new live mumps vaccine, Pariorix. The results of the present study indicate that the strain Urabe-Am 9 of the mumps virus (Pariorix) induces antibodies in 100% of seronegative adults when measured by ELISA and in 70.6% and 64.7% in HIG and HI, respectively. ELISA is therefore a very sensitive and reliable method for the demonstration of sero-conversion after vaccination. The vaccine was well tolerated and clinically acceptable in the group of adult volunteers.

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“…of meningitis or encephalitis without evidence of parotitis. Other viral diseases may mimic the clinical picture of mumps [Zollar and Mufson, 1970;Buckley et al, 1972;Biedel, 19781. Furthermore, it may &.important to detect past exposure to mumps virus or to control success of vaccination.…”

Section: Introductionmentioning

confidence: 99%

Enzyme‐linked immunosorbent assay (ELISA) for mumps virus antibodies

Popow‐Kraupp

1981

Journal of Medical Virology

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An ELISA for the detection of mumps virus-specific IgG and IgM antibodies was developed. Three different antigen preparations were compared. Equally good results were obtained with virus concentrated by ultracentrifugation and with virus that was further purified by sucrose gradient centrifugation. Crude infected allantoic fluid was unsuitable for use an antigen. The variability and reproducibility of the tests were satisfactory. When the ELISA was compared to conventional serological methods, a good correlation of IgG absorbance values with complement fixation (CF) antibody titers was found (r = 0.574), the ELISA being more sensitive in detecting antibodies in acute-phase sera. For the determination of immunity, ELISA IgG values were compared with results obtained in hemagglutination-inhibition (HI) and hemolysis-in-gel (HIG) tests. Again there was a good correlation with both tests (rHI = 0.528, rHIG = 0.667). The ELISA was more sensitive than the HI and HIG test for the detection of low levels of antibodies.

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Parotitis and Parainfluenza 3 Virus

Cited by 13 publications

References 1 publication

Parainfluenza Viruses

Parainfluenza Viruses

Antibody response after application of a new live attenuated mumps vaccine (Pariorix®) measured by enzyme‐linked immunosorbent assay (ELISA)

Enzyme‐linked immunosorbent assay (ELISA) for mumps virus antibodies

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