Parotid salivary secretion in diabetic autonomic neuropathy

Newrick, P. G.; Bowman, Clive; Green, D.; O'Brien, I.A.D.; Porter, Stephen; Scully, Crispian; Corrall, R. J. M.

doi:10.1016/0891-6632(91)90008-d

Cited by 49 publications

(38 citation statements)

References 12 publications

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“…26,27 Other causes may include dehydration or side effects of concomitant drug therapy commonly used in diabetic patients (e.g., antihypertensives, diuretics, and antidepressants).…”

Section: Salivary Gland Changesmentioning

confidence: 99%

Non-Periodontal Oral Manifestations of Diabetes: A Framework for Medical Care Providers

Gandara

Morton

2011

Diabetes Spectrum

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“…26,27 Other causes may include dehydration or side effects of concomitant drug therapy commonly used in diabetic patients (e.g., antihypertensives, diuretics, and antidepressants).…”

Section: Salivary Gland Changesmentioning

confidence: 99%

Non-Periodontal Oral Manifestations of Diabetes: A Framework for Medical Care Providers

Gandara

Morton

2011

Diabetes Spectrum

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“…Diabetes and hypertension are pathological states accompanied by impaired sympathetic function (29,36). In diabetes, reduced sympathetic activity in several territories is a feature of the autonomic diabetic neuropathy (34).…”

mentioning

confidence: 99%

SGLT1 protein expression in plasma membrane of acinar cells correlates with the sympathetic outflow to salivary glands in diabetic and hypertensive rats

Sabino-Silva

Alves-Wagner

Burgi

et al. 2010

American Journal of Physiology-Endocrinology and Metabolism

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Salivary gland dysfunction is a feature in diabetes and hypertension. We hypothesized that sodium-glucose cotransporter 1 (SGLT1) participates in salivary dysfunctions through a sympathetic- and protein kinase A (PKA)-mediated pathway. In Wistar-Kyoto (WKY), diabetic WKY (WKY-D), spontaneously hypertensive (SHR), and diabetic SHR (SHR-D) rats, PKA/SGLT1 proteins were analyzed in parotid and submandibular glands, and the sympathetic nerve activity (SNA) to the glands was monitored. Basal SNA was threefold higher in SHR ( P < 0.001 vs. WKY), and diabetes decreased this activity (∼50%, P < 0.05) in both WKY and SHR. The catalytic subunit of PKA and the plasma membrane SGLT1 content in acinar cells were regulated in parallel to the SNA. Electrical stimulation of the sympathetic branch to salivary glands increased (∼30%, P < 0.05) PKA and SGLT1 expression. Immunohistochemical analysis confirmed the observed regulations of SGLT1, revealing its location in basolateral membrane of acinar cells. Taken together, our results show highly coordinated regulation of sympathetic activity upon PKA activity and plasma membrane SGLT1 content in salivary glands. Furthermore, the present findings show that diabetic- and/or hypertensive-induced changes in the sympathetic activity correlate with changes in SGLT1 expression in basolateral membrane of acinar cells, which can participate in the salivary glands dysfunctions reported by patients with these pathologies.

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“…Dryness of the mouth as a feature of uncontrolled diabetes was first described in 1942 51,52 . The xerostomia may be a consequence of dehydration, although long-standing oral dryness may be due to microvascular disease and neuropathy affecting the major salivary glands 53 .…”

Section: Xerostomiamentioning

confidence: 99%

Different oral manifestations of diabetes mellitus and its complications a review

Kadiyala¹,

Kumar²

2017

Int j curr adv res

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Objective: To relate different oral manifestations and oral complications of diabetes mellitus Background: Diabetes mellitus is a chronic lifestyle disease affecting all age groups. It is one of the leading causes of mortality and morbidity worldwide. The term "diabetes mellitus" describes a group of disorders characterised by elevated levels of glucose in the blood and abnormalities of carbohydrate, fat and protein metabolism. A number of oral diseases and disorders have been associated with diabetes mellitus, and periodontitis has been identified as a possible risk factor for poor metabolic control in subjects with diabetes. The article will speak in depth about the complications of diabetes mellitus. This article aims to review and increase the awareness of oral manifestations and complications of diabetes mellitus and to stimulate research on the subject. Reason: It is important to know the different oral manifestations of diabetes mellitus to prevent its complications at the early stages. INTRODUCTIONDiabetes mellitus is a growing public health concern and a common chronic metabolic disease worldwide [1][2][3][4] . Diabetes mellitus represents a group of metabolic diseases that are characterised by hyperglycaemia due to a total or relative lack of insulin secretion and insulin resistance or both. The metabolic abnormalities involve carbohydrate, protein and fat metabolism. Diabetes mellitus affects all age groups, but is more common in adults. The World Health Organization (WHO) has recently declared it to be a pandemic 2 . Its prevalence has increased dramatically over the past few decades and it is expected to triple in the next decade. Diabetes mellitus is considered a leading cause of death due to its microvascular and macrovascular complications 5,6 . The most common types of diabetes are type 1 (insulin dependent) and type 2 (non-insulin-dependent) 7,8 . Type 2 is the more prevalent type. Countries with the highest rates of diabetes in the Eastern Mediterranean region and the Middle East are the United Arab Emirates, Saudi Arabia, Bahrain, Kuwait and Oman 9. Oman is one of the countries that has a high prevalence of diabetes mellitus, especially type 2 diabetes, and its prevalence is expected to increase in the next twenty years 10,11 .Various inflammatory diseases and soft tissue pathologies in oral cavities are associated with diabetes mellitus [12][13][14] . However, awareness of these complications is lacking worldwide [15][16][17][18] . Periodontal diseases have been proposed as the sixth most prevalent complication of diabetes mellitus following the other diabetic complications 19 . It has been reported as a more frequent oral complication of diabetes compared to other oral manifestations such as dry mouth and caries. Periodontitis is more frequent and severe in patients with diabetes with poor glycaemic control. Early identification and/or management of these oral manifestations may help in the early diagnosis of diabetes and in attaining better glycaemic control 20 . Therefore, diabetic oral c...

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Parotid salivary secretion in diabetic autonomic neuropathy

Cited by 49 publications

References 12 publications

Non-Periodontal Oral Manifestations of Diabetes: A Framework for Medical Care Providers

Non-Periodontal Oral Manifestations of Diabetes: A Framework for Medical Care Providers

SGLT1 protein expression in plasma membrane of acinar cells correlates with the sympathetic outflow to salivary glands in diabetic and hypertensive rats

Different oral manifestations of diabetes mellitus and its complications a review

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