Parotid salivary immunoglobulins, recurrent respiratory tract infections and gingival health in institutionalized and non‐institutionalized subjects with Down's syndrome

Chaushu, Stella; Nof, E.; Becker, Adrian; Shapira, Joseph; Chaushu, Gavriel

doi:10.1046/j.1365-2788.2003.00446.x

Cited by 13 publications

(7 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Increased serum IgG levels and decreased IgM levels have been reported in DS children in late childhood and adolescence (6), as well as an increase of these immunoglobulins in saliva (17). Our DS children had increased serum IgG levels compared to controls, reflecting an overstimulation of B lymphocytes mainly due to IgG1 and IgG3 isotypes since these levels were elevated in the majority of DS children.…”

Section: Discussionsupporting

confidence: 57%

Antibody response to pneumococcal capsular polysaccharide vaccine in Down syndrome patients

Costa‐Carvalho¹,

Martínez²,

Dias³

et al. 2006

Braz J Med Biol Res

View full text Add to dashboard Cite

The majority of children with Down syndrome (DS) tend to have frequent bacterial infections including recurrent respiratory infections. Our objective was to evaluate the production of antibodies to pneumococcal polysaccharide antigens after active immunization in DS subjects. IgG antibodies to pneumococcal serotypes (1, 3, 6B, 9V, and 14) were measured before and 6 weeks after immunization with a 23-valent pneumococcal vaccine (Pneumo23 ® , Pasteur-Merrieux) in 6-to 13-year-old DS children (N = 17) and in aged-matched normal controls (N = 30). An adequate response was defined as a 4-fold increase over baseline or a post-immunization level of specific pneumococcal serotype antibody ≥1.3 µg/mL. After immunization, all DS children had an increase in post-immunization levels against all serotypes analyzed. A 4-fold or more increase was observed in all DS children concerning serotypes 1 and 14, in 90% of subjects for serotypes 3 and 9V, and in 65% for serotype 6B. Regarding this increase, 8 of the 17 DS children had an adequate response to all serotypes analyzed, 8/17 patients to 4 serotypes and 1/17 to 3 serotypes. However, when we compared post-immunization levels between DS children and controls, we observed lower levels in the former group (P < 0.05) for all serotypes except serotype 3. We conclude that pneumococcal polysaccharide immunization could be beneficial for these DS children.

show abstract

Section: Discussionsupporting

confidence: 57%

Antibody response to pneumococcal capsular polysaccharide vaccine in Down syndrome patients

Costa‐Carvalho¹,

Martínez²,

Dias³

et al. 2006

Braz J Med Biol Res

View full text Add to dashboard Cite

show abstract

“…We have also conducted several community studies (6), but with smaller number of participants or with specialized populations like, for example, Down syndrome (14, 15). In one general study of aging and intellectual disability (10) from the Jerusalem area, we compared persons (40 years and older) living in community residence ( n = 65) with those living at home ( n = 43).…”

Section: Dental Care In Israel For This Populationmentioning

confidence: 99%

Intellectual Disability and Dental Services: Experience from Israel

Feldberg

Merrick

2014

Front. Public Health

View full text Add to dashboard Cite

“…Another study also showed that resting whole saliva flow rate in 70 Down syndrome adults was 0.05 ml/min (range, 0-0.41 ml/ min), compared to 0.55 ml/min (range, 0.05-1.64 ml/min) in healthy control adults, indicating a 90% reduction, with a significant reduction in stimulated parotid saliva secretion also found [52]. Many other reports support an age-dependent deficiency of salivary secretion in Down syndrome individuals [51,[53][54][55][56].…”

Section: Salivary Factorsmentioning

confidence: 86%

“…In contrast, older Down syndrome patients showed an extreme reduction (>92%) in specific salivary sIgA against P. gingivalis, Aggregatibacter (formerly Actinobacillus) actinomycetemcomitans, and Streptococcus mutans as compared to age-matched controls [52]. Furthermore, an increased vulnerability to recurrent upper respiratory infections was attributed to this reduction in salivary sIgA secretion [56]. Such a severe salivary immunodeficiency related to age was suggested to intensify the risk of periodontal destruction in Down syndrome adults.…”

Section: Sigamentioning

confidence: 95%