Parotid saliva composition during and after irradiation of head and neck cancer

Funegård, Ulrika; Franzén, Lars; Ericson, Thomas; Henriksson, Roger

doi:10.1016/0964-1955(94)90002-7

Cited by 56 publications

(27 citation statements)

References 20 publications

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“…The findings are similar to those of Almståhl and Wikström 16 and Funegård et al 54 who noted that calcium concentration in stimulated parotid saliva were higher one year after completion of radiation therapy compared to baseline values. These findings suggest that the altered function in calcium secretion is maintained for many months after RT, and could be contributory to mucosal discomfort as reported by Agha-Hosseini.…”

Section: Discussionsupporting

confidence: 90%

Analysis of factors influencing the development of xerostomia during intensity-modulated radiotherapy

Randall

Stevens

Yepes

et al. 2013

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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OBJECTIVES Factors influencing xerostomia during intensity-modulated radiation therapy (IMRT) were assessed. METHODS A 6-week study of 32 head and neck cancer (HNC) patients was performed. Subjects completed the Xerostomia Inventory (XI) and provided stimulated saliva (SS) at baseline, week two and at end of IMRT. Influence of SS flow rate (SSFR), calcium and mucin 5b (MUC5b) concentrations and radiation dose on xerostomia was determined. RESULTS HNC subjects experienced mean SSFR decline of 36% by visit two (N=27; p=0.012) and 57% by visit three (N=20; p=0.0004), Concentrations of calcium and MUC5b increased, but not significantly during IMRT (p>0.05). Xerostomia correlated most with decreasing salivary flow rate as determined by Spearman correlations (p<0.04) and linear mixed models (p<0.0001). CONCLUSIONS Although IMRT is sparing to the parotid glands, it has an early effect on SSFR and the constituents in saliva in a manner that is associated with the perception of xerostomia.

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Section: Discussionsupporting

confidence: 90%

Analysis of factors influencing the development of xerostomia during intensity-modulated radiotherapy

Randall

Stevens

Yepes

et al. 2013

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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“…In contrast, in the present pilot study, patients had ended radiotherapy for at least 6 months; therefore, the negative results obtained with regard to LLLT can be attributed to late alterations caused by ionizing radiation in the glandular structure. All patients had received ionizing radiation doses ranging from 45 to 70 Gy, which several authors [35][36][37] consider irreversible for glandular function restoration.…”

Section: Discussionmentioning

confidence: 99%

Effect of Low-Level Laser Therapy on Radiotherapy-Induced Hyposalivation and Xerostomia: A Pilot Study

Saleh

Figueiredo

Cherubini

et al. 2014

Photomedicine and Laser Surgery

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“…Elevations in proteins such as slgA, lactoferrin, or salivary peroxidase have been reported most often (Tabak et al, 1978;Stuchell et al, 1984;Atkinson et al, 1991;Funegard et al, 1994), although decreases in slgA and lactoferrin have also been seen (Umazume et al, 1995). In one study, persons who developed post-irradiation caries while receiving fluoride therapy displayed lower levels of slgA than patients who remained cariesfree.…”

Section: (Ill) Evidence For Effects Of Salivary Proteins In Vivo (A) mentioning

confidence: 99%

Does Variability in Salivary Protein Concentrations Influence Oral Microbial Ecology and Oral Health?

Rudney

1995

Critical Reviews in Oral Biology & Medicine

108

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Salivary protein interactions with oral microbes in vitro include aggregation, adherence, cell-killing, inhibition of metabolism, and nutrition. Such interactions might be expected to influence oral ecology. However, inconsistent results have been obtained from in vivo tests of the hypothesis that quantitative variation in salivary protein concentrations will affect oral disease prevalence. Results may have been influenced by choices made during study design, including saliva source, stimulation status, control for flow rate, and assay methods. Salivary protein concentrations also may be subject to circadian variation. Values for saliva collected at the same time of day tend to remain consistent within subjects, but events such as stress, inflammation, infection, menstruation, or pregnancy may induce short-term changes. Long-term factors such as aging, systemic disease, or medication likewise may influence salivary protein concentrations. Such sources of variation may increase the sample size needed to find statistically significant differences. Clinical studies also must consider factors such as human population variation, strain and species differences in protein-microbe interactions, protein polymorphism, and synergistic or antagonistic interaction between proteins. Salivary proteins may form heterotypic complexes with unique effects, and different proteins may exert redundant effects. Patterns of protein-microbe interaction also may differ between oral sites. Future clinical studies must take those factors into account. Promising approaches might involve meta-analysis or multi-center studies, retrospective and prospective longitudinal designs, short-term measurement of salivary protein effects, and consideration of individual variation in multiple protein effects such as aggregation, adherence, and cell-killing.

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Parotid saliva composition during and after irradiation of head and neck cancer

Cited by 56 publications

References 20 publications

Analysis of factors influencing the development of xerostomia during intensity-modulated radiotherapy

Analysis of factors influencing the development of xerostomia during intensity-modulated radiotherapy

Effect of Low-Level Laser Therapy on Radiotherapy-Induced Hyposalivation and Xerostomia: A Pilot Study

Does Variability in Salivary Protein Concentrations Influence Oral Microbial Ecology and Oral Health?

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