Parotid pleomorphic and non-pleomorphic adenomas: a mono-institutional series of 512 patients

Lombardi, Davide; Tomasoni, Michele; Nicolai, Alessio; Paderno, Alberto; Grammatica, Alberto; Arcuri, Mara; Lancini, Davide; Battocchio, Simonetta; Ardighieri, Laura; Bozzola, Anna; Pittiani, Frida; Farina, Davide; Zinis, Luca Oscar Redaelli de; Nicolai, Piero; Piazza, Cesare

doi:10.1007/s00405-021-07018-7

Cited by 5 publications

(6 citation statements)

References 27 publications

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“…Many retrospective studies involving total parotidectomy and extracapsular dissection show very little recurrence or no recurrence from spillage, 4,16,19,21,26,27 whereas some cases had no data specified for spillage but had a low recurrence rate post radiation therapy. 10,14 Others did not specify any cause of recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…PA marks very distinctive histopathologic and biological features that have posed a constant challenge to surgeons in optimizing treatment outcomes and minimizing recurrence rates 4 . The recurrence of PA stems from tumour‐related factors, such as tumour size, histopathological subtype, encapsulation and other factors like capsule thickness or its absence, pseudopodia, satellite nodules multi‐centricity 1,3 .…”

Section: Introductionmentioning

confidence: 99%

“…1 Thus, identifying the factors contributing to PA recurrence is essential to improve the treatment methods and the prognosis.PA marks very distinctive histopathologic and biological features that have posed a constant challenge to surgeons in optimizing treatment outcomes and minimizing recurrence rates. 4 The recurrence of PA stems from tumour-related factors, such as tumour size, histopathological subtype, encapsulation and other factors like capsule thickness or its absence, pseudopodia, satellite nodules multi-centricity. 1,3 Other surgery-related factors including rupture of the tumour, spillage of tumour contents, invaded margins, insufficient margins of resection due to proximity to nerve branches have also been reported.…”

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confidence: 99%

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Role of intraoperative tumour spillage in prognostic outcome of pleomorphic adenoma: A systematic review

Agrawal,

Mehta,

Sengupta

et al. 2024

Oral Surgery

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BackgroundPleomorphic adenoma (PA) is the most common neoplasm of salivary gland origin. The exact cause of PA recurrence is ambiguous. Incomplete surgical excision and violation or accidental rupture of tumour capsule are the widely accepted causes.AimTo study intraoperative tumour spillage‐associated recurrence and prognosis in cases of PA of the parotid gland.Materials and MethodsA systematic literature search was performed to include case series and observational studies discussing about intraoperative tumour spillage and recurrence in PA of the parotid gland. Quality assessment for the included studies cases was performed based on Joanna Briggs Institute checklist.ResultsA total of 27 studies were included in this review. The majority of the studies reported about cases of intraoperative tumour spillage in PA of the parotid gland. Overall, 12 studies specifically mentioned about the relation of tumour spillage with tumour recurrence. A total of 3 studies observed the association between the mode of treatment and tumour spillage and recurrence.ConclusionIntraoperative tumour spillage is a major factor responsible for PA recurrence. A comprehensive knowledge of the recurrence risk factors is of utmost importance. The results of this systematic review aim to make clinicians and surgeons aware that the capsular status of PA is a principal aspect to be taken care of.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Role of intraoperative tumour spillage in prognostic outcome of pleomorphic adenoma: A systematic review

Agrawal,

Mehta,

Sengupta

et al. 2024

Oral Surgery

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“…For this reason, more extended surgical techniques are preferred for the treatment of pleomorphic adenoma. Another criterion for extended surgical treatment is recurrence [ 42 , 43 ].…”

Section: Therapeutic and Prognostic Implications Of Correct Diagnosismentioning

confidence: 99%

Salivary gland pathologies: evolution in classification and association with unique genetic alterations

Žůrek

Fus

Niemczyk

et al. 2023

Eur Arch Otorhinolaryngol

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Purpose The correct classification of salivary gland pathologies is crucial for choosing a treatment method and determining the prognosis. Better outcomes are now achievable thanks to the introduction of new therapy approaches, such as targeted therapies for malignant salivary gland tumors. To apply these in clinical routine, a clear classification of the lesions is required. Methods The following review examines all changes from the first World Health Organization (WHO) Classification of salivary gland pathologies from 1972 to fifth edition from 2022. Possible developments in the diagnosis and classification of salivary gland pathology are also presented. Results The current WHO classification is the fifth edition. With the development of new diagnostic methods, based on genetic alterations, it provides insight into the molecular basis of lesions. This has resulted in the evolution of classification, introduction of new entities and reclassification of existing ones. Conclusions Genetic alterations will become increasingly more significant in the identification of salivary gland pathologies in the future. These alterations will be helpful as prognostic and predictive biomarkers, and may also serve as targets for anti-cancer therapies.

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“…AL, however, typically only requires partial parotidectomy. However, in PA cases, tumor cells can be detected at the resection margins in 41.9% of cases ( 4 ). This could be one of the reasons why PA is more prone to relapse.…”

Section: Introductionmentioning

confidence: 99%

Radiomic nomogram for discriminating parotid pleomorphic adenoma from parotid adenolymphoma based on grayscale ultrasonography

Mao,

Jiang,

Wang

et al. 2024

Front. Oncol.

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ObjectivesTo differentiate parotid pleomorphic adenoma (PA) from adenolymphoma (AL) using radiomics of grayscale ultrasonography in combination with clinical features.MethodsThis retrospective study aimed to analyze the clinical and radiographic characteristics of 162 cases from December 2019 to March 2023. The study population consisted of a training cohort of 113 patients and a validation cohort of 49 patients. Grayscale ultrasonography was processed using ITP-Snap software and Python to delineate regions of interest (ROIs) and extract radiomic features. Univariate analysis, Spearman’s correlation, greedy recursive elimination strategy, and least absolute shrinkage and selection operator (LASSO) correlation were employed to select relevant radiographic features. Subsequently, eight machine learning methods (LR, SVM, KNN, RandomForest, ExtraTrees, XGBoost, LightGBM, and MLP) were employed to build a quantitative radiomic model using the selected features. A radiomic nomogram was developed through the utilization of multivariate logistic regression analysis, integrating both clinical and radiomic data. The accuracy of the nomogram was assessed using receiver operating characteristic (ROC) curve analysis, calibration, decision curve analysis (DCA), and the Hosmer–Lemeshow test.ResultsTo differentiate PA from AL, the radiomic model using SVM showed optimal discriminatory ability (accuracy = 0.929 and 0.857, sensitivity = 0.946 and 0.800, specificity = 0.921 and 0.897, positive predictive value = 0.854 and 0.842, and negative predictive value = 0.972 and 0.867 in the training and validation cohorts, respectively). A nomogram incorporating rad-Signature and clinical features achieved an area under the ROC curve (AUC) of 0.983 (95% confidence interval [CI]: 0.965–1) and 0.910 (95% CI: 0.830–0.990) in the training and validation cohorts, respectively. Decision curve analysis showed that the nomogram and radiomic model outperformed the clinical-factor model in terms of clinical usefulness.ConclusionA nomogram based on grayscale ultrasonic radiomics and clinical features served as a non-invasive tool capable of differentiating PA and AL.

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Parotid pleomorphic and non-pleomorphic adenomas: a mono-institutional series of 512 patients

Cited by 5 publications

References 27 publications

Role of intraoperative tumour spillage in prognostic outcome of pleomorphic adenoma: A systematic review

Role of intraoperative tumour spillage in prognostic outcome of pleomorphic adenoma: A systematic review

Salivary gland pathologies: evolution in classification and association with unique genetic alterations

Radiomic nomogram for discriminating parotid pleomorphic adenoma from parotid adenolymphoma based on grayscale ultrasonography

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