Parotid mucoepidermoid carcinoma in children

Marlowe, Julius F.; Hora, Julius F.

doi:10.1288/00005537-196801000-00005

Cited by 13 publications

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A low percentage of poorly differentiated tu mors has also been noted by other authors [1,3,24], We have observed 2 cases of the clear cell variant of a mucoepidermoid tu mor. Independently of their grade, most mu coepidermoid tumors displayed infiltrative growth, and sometimes invasion of blood vessels.…”

Section: Discussionsupporting

confidence: 87%

Epithelial Salivary Gland Tumors in Children and Adolescents

Seifert

Okabe

Caselitz

1986

ORL

View full text Add to dashboard Cite

In the Salivary Gland Register (University of Hamburg), 9883 cases were recorded from 1965 to 1984. Among these cases there were 3,326 neoplasms, of which 3,017 were epithelial in origin. In this latter group, 80 neoplasms arose in children and adolescents. Among these 80 persons, there was a slight predominance of females; 57 tumors (71 %) were localized in the parotid gland, and only 6 (8 %) in the submandibular gland. The incidence of the tumor types was different in children and adolescents as compared to the incidence in adults: monomorphic adenomas were virtually absent in children (only 1 patient), and benign tumors were also less common (65%). The incidence of mucoepidermoid tumors was remarkable (12 cases, 15 %). Acinic cell tumors occurred more frequently (5 cases, 6 %). The neoplasms have been analyzed histologically. Two very rare tumors, a monomorphic salivary duct adenoma and an embryonal carcinoma, were also studied by electron microscopy and immunohistochemistry.

show abstract

Section: Discussionsupporting

confidence: 87%

Epithelial Salivary Gland Tumors in Children and Adolescents

Seifert

Okabe

Caselitz

1986

ORL

View full text Add to dashboard Cite

show abstract

Malignant Parotid Tumors in Patients Under 20 Years of Age

Byers¹,

Piórkowski²,

Luna³

1984

Archives of Otolaryngology - Head and Neck Surgery

View full text Add to dashboard Cite

\s=b\Since 1944, 26 patients with parotid cancer who were under 20 years of age have been seen and treated at the University of Texas M. D. Anderson Hospital and Tumor Institute at Houston by a single group of surgeons with a similar therapeutic approach. Follow-up data were obtained in all patients up to 26 years. Mucoepidermoid and adenocarcinomas were the most common histologic cell types. None of the 26 patients initially had either facial nerve paralysis or palpable nodal metastasis. Initial treatment for 21 of the 26 patients consisted of a parotidectomy and neck dissection. The overall absolute two-year survival and above\x=req-\ clavicle control was 88%. A poor prognosis correlated well with adverse tumor criteria such as poor differentiation histologically, nodal metastasis, nerve invasion, and locally invasive disease. Aggressive local-regional treatment is recommended since only two patients died of distant metastasis as the sole manifestation of their treatment failure. The use of postoperative irradiation must be carefully selected in these young patients since severe irradiation complications developed in three of the five long-term survivors. (Arch Otolaryngol 1984;110:232-235) Si nce cancer arising in the salivary gland tissue of the parotid is rare in children and young adults, the worldwide experience is sporadic and is usually limited to case reports in the literature. Several collective reviews of all types of parotid tumors from many institutions have been reported,17 but no single institution has a large enough experience on which to base any statistically valid recommendations regarding treat¬ ment of parotid cancer in chil¬ dren. Since 1944, 26 patients with par¬ otid cancer who were under 20 years of age have been seen and treated at the University of Texas M. D. Ander¬ son Hospital and Tumor Institute at Houston by a single group of surgeons with a similar therapeutic approach. A retrospective analysis of the results of treatment of these patients forms the basis of this study. SUBJECTS AND METHODSBetween 1944 and 1981, the medical records of 26 patients under the age of 20 years with the diagnosis of primary parot¬ id cancer were reviewed. The diagnosis of salivary gland cancer was confirmed in all cases by the pathologists at the University of Texas M. D. Anderson Hospital and Tumor Institute at Houston. An attempt was made to grade histologically each ade¬ nocarcinoma into well-differentiated or poorly differentiated, and each mucoepi¬ dermoid cancer into grades 1 through 3, independent of any clinical information. Mucoepidermoid CarcinomasLow-grade carcinoma produced wellformed glandular or cystic spaces. These cysts were lined by a single layer of mucin-producing cells. A few epidermoid and/or intermediate cells were present.Mitosis and nuclear pleomorphism were extremely rare. These tumors showed a variable degree of infiltration into the adjacent tissue. The invasion was in the manner of a broad advancing front rather than in a destructive manner.In high-grade carcinomas there ...

show abstract

Tumors of the Major Salivary Glands in Children

Shikhani

Johns

1988

Head & Neck Surgery

View full text Add to dashboard Cite

During the 30-year period 1955-1985, 21 children with neoplasms of the major salivary glands were treated at the Johns Hopkins Hospital. A thorough review of the English literature revealed an additional 472 cases. The cases were studied as to age, sex, site, histopathologic characteristics, mode of treatment, and results. The majority of the patients were between 8 and 20 years of age. There was a female preponderance of 1.42:1. The parotid gland was the site of origin in 85.1%, the submandibular in 11.7%, and the sublingual in 3.2%. An equal incidence of benign (50.1%) and malignant (49.9%) lesions is noted. Pleomorphic adenoma was the most common benign neoplasm and mucoepidermoid carcinoma the most common malignant neoplasm. The final prognosis seems to be similar with superficial or total parotidectomy, provided the tumor has been completely removed at the initial surgery. Re-excision is recommended for tumor recurrence, and the use of radiation therapy should be individually determined in cases of aggressive malignancies.

show abstract

Parotid mucoepidermoid carcinoma in children

Cited by 13 publications

References 3 publications

Epithelial Salivary Gland Tumors in Children and Adolescents

Epithelial Salivary Gland Tumors in Children and Adolescents

Malignant Parotid Tumors in Patients Under 20 Years of Age

Tumors of the Major Salivary Glands in Children

Contact Info

Product

Resources

About