Parotid Gland Biopsy and 67Ga Imaging Correlation in Systemic Sarcoidosis

Brantley, Steven D.; Orzel, Joseph A.; Weiland, Frederick L.; Bower, Jeffrey H.

doi:10.1378/chest.91.3.403

Cited by 14 publications

(7 citation statements)

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“…1 The parotid gland is rarely affected by sarcoidosis, and clinical manifestation of sarcoidosis of the parotid glands has been reported in only 6% of the cases. 2 Brantley et al 3 reported about 11 (58%) positive parotid gland biopsies in 19 patients with proven generalized sarcoidosis. The rate of subclinical parotid gland involvement seems to be higher than assumed.…”

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confidence: 99%

Parotid gland involvement in sarcoidosis: Sonographic features

Teymoortash

Werner

2009

J of Clinical Ultrasound

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Parotid gland involvement in sarcoidosis: Sonographic features

Teymoortash

Werner

2009

J of Clinical Ultrasound

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“…Previous literature indicated that the parotid gland can be affected by sarcoidosis (6–30%) . Brantley et al reported approximately 11 positive parotid gland biopsy results (58%) in 19 patients with proven generalized sarcoidosis. We found a Hočevar score above the control range in approximately 19% of our sample, and in 37% when using a cutoff score of 15, as suggested in some studies .…”

Section: Discussionmentioning

confidence: 99%

Comparison of Ultrasound Features of Major Salivary Glands in Sarcoidosis, Amyloidosis, and Sjögren's Syndrome

Law

Jafarzadeh

Govender

et al. 2020

Arthritis Care & Research

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Objective While salivary gland ultrasound (SGU) has gained prominence for evaluating Sjögren's syndrome, little information exists on SGU appearance of sarcoidosis and amyloidosis, potential mimics of Sjögren's syndrome. Our goal in this study was to estimate the diagnostic accuracy of major SGU features in differentiating Sjögren's syndrome from sarcoidosis, amyloidosis, and controls. Methods We enrolled consecutive adult ambulatory patients with a clinical diagnosis of Sjögren's syndrome fulfilling the 2016 American College of Rheumatology (ACR) classification criteria; we also enrolled patients with a clinical diagnosis of sarcoidosis or systemic immunoglobulin light chain (AL) amyloidosis, with histologic confirmation from any tissue, and rheumatology outpatients without diagnoses affecting salivary glands. Subjects underwent major SGU using the Hočevar protocol, with resulting video clips reviewed blind to clinical diagnosis. Results Sjögren's syndrome SGU scores were greater than in patients from the other groups, but there were no distinguishing salivary gland features from AL amyloidosis or sarcoidosis. None of the patients in the control group scored higher than 17, a cutoff previously suggested for Sjögren's syndrome, but 27% of patients with AL amyloidosis and 19% with sarcoidosis scored higher than 17. Adding Hočevar SGU scores of ≥17 to the 2016 ACR/European League Against Rheumatism criteria in a parallel scheme increased the sensitivity for Sjögren's syndrome from 87% to 98%, while combining the 2 criteria in series increased specificity from 81% to 98%. Conclusion Sjögren's syndrome, sarcoidosis, and AL amyloidosis share common SGU features that can help distinguish these conditions from patients without systemic rheumatologic disease. Clinicians should carefully consider these potential mimics when interpreting salivary gland US results.

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“…12,[33][34][35][36][37][38][39] For example, Brantley et al found that parotid gland biopsy yield was marginally higher in those with abnormal gallium parotid uptake. 40 To our knowledge, little research has been done to quantify uptake in the lacrimal gland 10 and no study has correlated biopsy results with the intensity of gallium uptake in the lacrimal region.…”

Section: Discussionmentioning

confidence: 99%