Parosteal Osteosarcoma of the Proximal Phalanx of a Finger

Sadiq, Mohammed; Ismail, Mohammed; Dhanya, K.; Meganath, P.

doi:10.1016/j.jhsa.2019.08.006

Cited by 2 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in contrast with what has been previously reported in dogs, 16 but is consistent with some reports in the human literature where OSA of the hand or foot is treated by surgery alone. 18,32 Unfortunately, owing to the low incidence of OSA in this location, we were able to include only 15 cases and dogs were treated with a wide variety of treatments. Based on a power analysis, it would take a total of 260 patients to detect a 4 months difference in median ST, assuming a 10 months median ST in the shorter group, with a power of 0.8 and P-value of .05.…”

Section: Discussionmentioning

confidence: 99%

Biological behaviour of primary osteosarcoma of the digits, metacarpal and metatarsal bones in dogs

Tremolada

Thamm

Milovancev

et al. 2020

Vet Comparative Oncology

View full text Add to dashboard Cite

Osteosarcoma (OSA) arising from the digits, metatarsal and metacarpal bones is rare and may carry a better prognosis compared with other locations. The aim of this study was to retrospectively evaluate the biological behaviour, the progression free interval (PFI), the survival time (ST) and evaluate the effect of adjuvant chemotherapy for OSA affecting these bones. Medical records from two academic institutions were reviewed and 15 cases were included. Descriptive statistics were used for signalment and history. For estimation of median PFI and median ST, the Kaplan-Meier method was utilized. The prognostic effect of chemotherapy, lymphocyte and monocyte count was investigated. Log-rank analysis was used to compare PFI and ST between groups. The overall median PFI and median ST were 377 and 687 days, respectively. No significant differences were noted for any of the variables evaluated. In this study, dogs affected by OSA of digits, metacarpal and metatarsal bones appear to have a longer ST compared with dogs with OSA of other appendicular locations. A study with a larger number of patients is needed to confirm these results and investigate the potential benefit of adjuvant chemotherapy. | INTRODUCTIONOsteosarcoma (OSA) is an aggressive bone tumour arising from mesenchymal cells that produce osteoid, accounting for 85% of all primary bone tumours. [1][2][3][4][5] Patients affected are usually large to giant breed dogs with a median age of 7 years with Rottweiler, Golden Retriever, Labrador Retriever, Irish Setter and Greyhound overrepresented. 6,7

show abstract

Section: Discussionmentioning

confidence: 99%