Parosteal osteoliposarcoma: A new bone tumor (from imaging to immunophenotype)

Larousserie, Frédérique; Chen, X.; Ding, Yu; Kreshak, Jennifer; Cocchi, Stefania; Huang, Xiaoyuan; Niu, Xiaohui; Alberghini, Marco; Vanel, D.

doi:10.1016/j.ejrad.2011.11.035

Cited by 12 publications

(8 citation statements)

References 18 publications

(20 reference statements)

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“…More recently, a parosteal osteoliposarcoma was reported [21], also defined by WDL and LGO coexistence, but arising from the cortex of the underlying bone just like parosteal osteosarcoma, which in our case could not be proven by radiology, gross examination, or histology. Further molecular techniques could not be performed on this parosteal osteoliposarcoma, although the cells of both components were immunoreactive for CDK4.…”

Section: Discussionmentioning

confidence: 64%

Paravertebral Well-Differentiated Liposarcoma with Low-Grade Osteosarcomatous Component: Case Report with 11-Year Follow-Up, Radiological, Pathological, and Genetic Data, and Literature Review

Macagno

Fuentès

Pinieux

et al. 2017

Case Reports in Pathology

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Despite being one of the most frequent soft-tissue sarcomas, well-differentiated liposarcoma has never been reported near the spine. The authors present the case of a 67-year-old man with progressive history of back pain. Physical examination revealed a mass located within the right paravertebral muscles. MR and CT imaging showed a heavily ossified central mass surrounded by a peripheral fatty component. No connection with the underlying bone was detected on imagery and during surgery. After surgical resection, histopathological examination revealed a tumor harboring combined features of well-differentiated liposarcoma and low-grade osteosarcoma. Tumor cells displayed overexpression of MDM2, CDK4, and P16 by immunohistochemistry and CGH revealed amplification of 12q13-15 as the only genetic imbalance. MDM2 FISH analysis was performed but was inconclusive. The pathological, immunohistochemical, and genetic features, the differential diagnoses, and the therapeutic management of this unusual tumor are discussed. No complementary treatment was performed initially. Following first treatment, two recurrences occurred 6 and 9 years later, both displaying histological features similar to the first occurrence. Radiotherapy was started after the second recurrence. Follow-up shows no evidence of disease 11 years after initial diagnosis. This case was unusual due to the paravertebral location of the tumor and its divergent differentiation.

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Section: Discussionmentioning

confidence: 64%

Paravertebral Well-Differentiated Liposarcoma with Low-Grade Osteosarcomatous Component: Case Report with 11-Year Follow-Up, Radiological, Pathological, and Genetic Data, and Literature Review

Macagno

Fuentès

Pinieux

et al. 2017

Case Reports in Pathology

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“…The presence of both a benign and malignant mineralized bony matrix as well as a chondroid matrix have been described in lipomatous neoplasms. In benign lesions, mineralization is typically associated with fat necrosis [10]. Rare cases of ossifying lipoma have been described; they generally show lobules of mature adipose tissue intimately associated with benign bone and cartilage [11].…”

Section: Discussionmentioning

confidence: 99%

Atypical lipomatous tumor of the hand with transformation to dedifferentiated liposarcoma: a case report

et al. 2017

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Atypical lipomatous tumor/well-differentiated liposarcoma is the most common sarcoma of soft tissue in adults. We describe the clinical, radiologic, and pathologic features of an atypical lipomatous tumor arising within the soft tissue of the left hand of a 68-year-old female that underwent transformation to dedifferentiated liposarcoma and eventually metastasized. At initial presentation, imaging demonstrated an extensively calcified fatty soft tissue mass with displacement of the digits. Following biopsy and staged debulking, the patient subsequently developed local recurrence, dedifferentiation, and widespread metastases to the lungs, pancreas, bone, and soft tissues. To our knowledge, this is the first case of a cytogenetically proven atypical lipomatous tumor of the hand that has undergone dedifferentiation with widespread metastases.

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“…A Biopsy is required from its two components, i.e. bony base and peripheral fat 8 . These tumors are included in the differential diagnosis of parosteal lipoma.…”

Section: Discussionmentioning

confidence: 99%

“…bony base and peripheral fat. 8 These tumors are included in the differential diagnosis of parosteal lipoma.…”

Section: Discussionmentioning

confidence: 99%

Parosteal lipoma of humerus—A rare case

Chaudhary

Dube

Bhansali

et al. 2013

International Journal of Surgery Case Reports

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INTRODUCTIONParosteal lipoma is an extremely rare benign tumor composed mainly of mature adipose tissue with a bony component.PRESENTATION OF CASEThis study reports the case of a 65-year old woman with a big mass on the posteromedial aspect of the right upper arm since 1 year. The swelling was a slow growing, painless, nontender, immobile mass which was not fixed to skin. She had no complaints of painful or restricted movements of the shoulder joint. She had no history of trauma to the upper limb.MRI revealed a large 13 cm × 5 cm × 8 cm well defined, nonenhancing, lobulated, heterointense, predominantly fat intensity lesion with a small area of chondroid component measuring 2 cm × 1.6 cm in posteromedial aspect of proximal right humerus, seen completely separate from the adjacent muscles.DISCUSSIONThe patient underwent surgery under general anesthesia. Vertical elliptical incision was taken over the posterior border of the upper arm over the mass. The tumor was below the lower part of deltoid near the upper end of humerus, which formed the roof, and between the long and medial heads of triceps muscles. A part of tumor, measuring 6 cm × 5 cm × 5 cm, was under the long head of triceps displacing it along with radial nerve and vessels medially while the other part, measuring 7 cm × 6 cm × 3 cm, was under the medial head of triceps displacing it laterally. The tumor was excised undocking its periosteal attachment. The specimen weighed 250 g. On histopathology, the lesion was composed of mature lipocytes that had an intimate relationship with the periosteum. No cellular atypia or lipoblasts were seen.CONCLUSIONParosteal lipomas are rare neoplasias with no proven malignant potential. These tumors can be resected without much damage to the adjacent structures, thus preserving the function of the upper limb.

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Parosteal osteoliposarcoma: A new bone tumor (from imaging to immunophenotype)

Cited by 12 publications

References 18 publications

Paravertebral Well-Differentiated Liposarcoma with Low-Grade Osteosarcomatous Component: Case Report with 11-Year Follow-Up, Radiological, Pathological, and Genetic Data, and Literature Review

Paravertebral Well-Differentiated Liposarcoma with Low-Grade Osteosarcomatous Component: Case Report with 11-Year Follow-Up, Radiological, Pathological, and Genetic Data, and Literature Review

Atypical lipomatous tumor of the hand with transformation to dedifferentiated liposarcoma: a case report

Parosteal lipoma of humerus—A rare case

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