Parkinsonism-Dementia Complex

Lessell, Simmons

doi:10.1001/archneur.1962.04210050013003

Cited by 21 publications

(7 citation statements)

References 7 publications

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“…In 1962, Lessel et al [27] reported a prevalence for PDC of 118 per 100,000 with a male/female ratio of 2.5:1 and a mean age at onset of 50 years. The overall average annual mortality rate was 28/100,0000 population, and the median survival was 3.5 years.…”

Section: Pathologymentioning

confidence: 99%

“…ALS and PDC have been reported with high frequency among the Chamorro population of Rota [2, 27,38]. A recent study by Waring [39] found no new cases of ALS but a prevalence of 200/100,000 of PDC, based on 3 cases out of a total population of 1,502.…”

Section: Geographic Distribution and Familial Occurrence Of Pdcmentioning

confidence: 99%

“…A recent study by Waring [39] found no new cases of ALS but a prevalence of 200/100,000 of PDC, based on 3 cases out of a total population of 1,502. The prevalence of ALS and PDC among Chamorros in Saipan is considerably lower than among Chamorros on Guam and Rota [2,27]. In the most recent study, Waring reported no cases of ALS and an overall prevalence of 17/ 100,000 for PDC [39].…”

Section: Geographic Distribution and Familial Occurrence Of Pdcmentioning

confidence: 99%

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Neuroepidemiologic Research Initiatives on Guam: Past and Present

Wiederholt

1999

Neuroepidemiology

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Since the middle of this century, a remarkable concentration of cases of neurodegenerative disease(s), referred to as amyotrophic lateral sclerosis and Parkinson-dementia complex (ALS/PDC), has been recognized among Chamorro natives of Guam. Intense investigations over the last 4 decades have failed to determine the etiology of these invariably fatal diseases. Over the same time period, the incidence of ALS has decreased dramatically, the incidence of PDC has decreased, but to a lesser degree, and age at onset has shifted to a later age by about 1 decade. Almost 50% of demented patients present without the classical Parkinsonian features of PDC, and the morphological picture has changed. Results of past and present research initiatives are reviewed.

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Section: Pathologymentioning

confidence: 99%

Section: Geographic Distribution and Familial Occurrence Of Pdcmentioning

confidence: 99%

Section: Geographic Distribution and Familial Occurrence Of Pdcmentioning

confidence: 99%

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Neuroepidemiologic Research Initiatives on Guam: Past and Present

Wiederholt

1999

Neuroepidemiology

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“…16 , 17 In 1960s, the first studies describing the association of ALS and Parkinsonism-Dementia Complex (PDC) were published, referring to the indigenous Chamorro population, native inhabitants of Guam. 18 , 19 The higher incidence of the disease among patients’ relatives compared to control ones launched the basis of the familiar aspect of ALS+PDC. 20 Forty years after the former reports, greater risk persisted, being the new cases among patients’ relatives even in greater number than expected.…”

mentioning

confidence: 99%

Frontotemporal dementia in amyotrophic lateral sclerosis: from rarity to reality?

et al. 2016

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“…Up-to-date communi ty-based data are not available. Using this calibrated model, the prevalence of parkinson ism in Sweden was estimated as 167.9/100,000.The study of geographical differences in the prevalence of neurological diseases has been useful in the production of etiological hypotheses [1][2][3][4] and identification of risk factor [5][6][7], There are few hypotheses regarding the etiology of parkinsonism (paralysis agitans, PA) [8] but the low concor dance for the disease, as shown by a monozygotic twin study [9], has re newed interest in environmental risk factors. A study of such factors has to be based on representative data on the whole population of PA patients, best obtained from community-based surveys [8,10], but these are difficult to carry out in PA because a neurological examination is needed in order to reduce the number of false diagnoses, and they are expensive.…”

mentioning

confidence: 99%

Tracers for Paralysis Agitans in Epidemiological Research

Pedro¹,

Rosenqvist²

1984

Neuroepidemiology

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A mathematical model has been constructed to estimate the prevalence of parkinsonism from register information on the use of a tracer drug in a defined geographical area. The prevalence of parkinsonism was estimated for several European countries using data on rates of L-dopa derivatives in 1980. The estimates were compared with data from community-based surveys of parkinsonism. The precision of the estimates as calculated by the coefficient of variation ranged between 1.6 and 6.9% and the accuracy as measured by the standard deviation of the percent error was 9.1 %. Up-to-date community-based data are not available. Using this calibrated model, the prevalence of parkinsonism in Sweden was estimated as 167.9/100,000.

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Parkinsonism-Dementia Complex

Cited by 21 publications

References 7 publications

Neuroepidemiologic Research Initiatives on Guam: Past and Present

Neuroepidemiologic Research Initiatives on Guam: Past and Present

Frontotemporal dementia in amyotrophic lateral sclerosis: from rarity to reality?

Tracers for Paralysis Agitans in Epidemiological Research

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