Parkinsonism and dilatation of the perivascular spaces (État Criblé) of the striatum: A clinical, magnetic resonance imaging, and pathological study

Fénelon, Gilles; Gray, F; Wallays, C.; Poirier, Jean‐Paul; Guillard, A

doi:10.1002/mds.870100609

Cited by 44 publications

(41 citation statements)

References 12 publications

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“…A special MR imaging change of cribriform cavities in the BG was the feature of this group. An "état criblé" or "status cribrosum" has been previously proved to be multiple dVRS in pathologic studies 19 and has been reported only among cases of vascular Parkinsonism, 20 subcortical ischemic vascular dementia, 21,22 or CADASIL 23 but has not been reported in the general population, to our knowledge. The present data further emphasize that the accumulation of multiple dVRS is not rare and can occur in elderly people in the absence of severe disability or dementia.…”

Section: Discussionmentioning

confidence: 77%

Frequency and Location of Dilated Virchow-Robin Spaces in Elderly People: A Population-Based 3D MR Imaging Study

Zhu

Dufouil

Mazoyer

et al. 2011

AJNR Am J Neuroradiol

148

119

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Section: Discussionmentioning

confidence: 77%

Frequency and Location of Dilated Virchow-Robin Spaces in Elderly People: A Population-Based 3D MR Imaging Study

Zhu

Dufouil

Mazoyer

et al. 2011

AJNR Am J Neuroradiol

148

119

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“…Parkinsonizm olgularında etyolojide rol oynadığı ya da tesadüfen mi VRB gözlendiği bilinmemektedir, ancak ganglionları kortekse bağlayan subkortikal bölgelerde yoğunlaştığında VRB'lerin vasküler parkinsonizme yol açabileceği bildirilmiş yayınlar mevcuttur (5,14). Demans ve VRB ilişkisi ise daha az tartışılmış bir konudur.…”

Section: Discussionunclassified

“…Genişlemiş VRB'ler; hemen her yaş grubunda gözlenebilir ve sıklıkla bazal gangliyonlarda, sentrum semiovalede, mezensefalon ve subkortikal beyaz cevher bölgelerinde gösterilmiştir. Bu genişlemiş boşluklar yaşlanma, parkinsonizm, hipertansiyon, küçük damar hastalıkları ve hidrosefali ile ilişkilendirilmiştir, ancak parkinsonizm ve demans ile ilgili yayınlanmış olgular ve çalışmalar sınırlıdır (3)(4)(5) …”

Section: Introductionunclassified

Dementia and parkinsonism case secondary to giant cystic Virchow-Robin spaces

Çelik¹,

Ubur²,

Tekkanat³

et al. 2017

TÃ¼rk Beyin Damar Hast Derg

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ÖZETBeyindeki perivasküler boşluklar, diğer adıyla Virchow Robin boşlukları beynin parankimine penetre olan arter ve arteriollerin etrafını saran, intersitisyel sıvı ile dolu, düzgün sınırlı boşluklardır. Normalde 1-2 mm olan bu boşluklar sağlıklı bireylerde hemen her yaşta görülebilir ve genellikle asemptomatiktir. Genişlediklerinde ise bulundukları lokalizasyona ve yoğunluklarına göre farklı klinik özelliklerle karşımıza çıkabilirler. Genişlemiş Dev Virchow-Robin boşlukları hidrosefali, küçük damar hastalıkları ve başka nöropsikiyatrik hastalıklarla ilişkilendirilmiştir, ancak vasküler parkinsonizm ve subkortikal demans ile ilişkili vakalar nadirdir. Bu yazıda multilobule kistik dev Vichow-Robin boşluklarına ikincil vasküler parkinsonizm ve subkortikal demans olgusu sunulmaktadır. Anahtar Sözcükler: Virchow-Robin boşlukları, demans, parkinsonizm. DEMENTIA AND PARKINSONISM CASE SECONDARY TO GIANT CYSTIC VIRCHOW-ROBIN SPACES ABSTRACTThe perivascular spaces in the brain,called Virchow Robin spaces, are well-defined spaces filled with interstitial fluid accompanying the arteries and arterioles perforating the brain parenchyma. Normally 1 to 2 mm, these spaces can be seen in healthy individuals at almost any age and are usually asymptomatic. When they expand, they may cause different clinical characteristics depending on their localization and frequency. The enlarged giant Virchow-Robin spaces have been associated with hydrocephalus, small vessel diseases, and other neuropsychiatric disorders, but the causes associated with vascular parkinsonism and subcortical dementia are very rare. In this article, we present secondary vascular parkinsonism and subcortical dementia due to multilobule cystic giant Virchow-Robin spaces. Key Words: Virchow-Robin spaces, dementia, parkinsonism. GİRİŞ

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“…In particular, the nigrostriatal dopaminergic nerve terminals within the striatum are highly vulnerable to ischemia [11], and the concentration of L -dopa is reduced in the cerebrospinal fluid from patients with suspected VP as well as IPD [63]. This may in part explain the initial transient response to L -dopa in some present patients with SLP or CWMH without 4- to 6-Hz tremor and cogwheel rigidity and in reported cases with vascular lesions without evidence of coexistent IPD at autopsy [6, 15, 44]. On the other hand, parkinsonism in cases with CWMH may be produced through disconnection of the basal gray matter (corticostriatal and thalamocortical tracts) and cerebellum from the supplementary motor area [18]as has been assumed in cases with hydrocephalus [64, 65]and Binswanger’s disease [18, 66].…”

Section: Discussionmentioning

confidence: 99%

“…Second, there is variation in responsiveness to L -dopa among cases with IPD and other parkinsonian syndromes. L -Dopa-responsive cases with vascular lesions in the absence of pathological changes in the SNpc [15]and, conversely, L -dopa-unresponsive cases with pathological changes in the SNpc [44]have been reported. Third, IPD symptoms may possibly be modified by a few, small ischemic lesions [21, 45, 46].…”

Section: Discussionmentioning

confidence: 99%

Symptomatic Characteristics of Parkinsonism and the Width of Substantia nigra pars compacta on MRI According to Ischemic Changes in the Putamen and Cerebral White Matter: Implications for the Diagnosis of Vascular Parkinsonism

Tohgi

Takahashi²,

Abe³

et al. 2001

Eur Neurol

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To investigate the significance of vascular lesions as a cause of secondary parkinsonism, we analyzed the symptomatic characteristics, the width of the substantia nigra pars compacta (SNpc) on MRI and the responsiveness to L-dopa in 227 parkinsonian cases, excluding those with drug-induced parkinsonism and neurodegenerative diseases other than idiopathic Parkinson’s disease (IPD). They were classified into those without a significant infarct in the basal ganglia (n = 144), those with status lacunaris in the putamen (SLP; n = 66) and those with confluent white matter hyperintensity signals (CWMH; n = 17). The 4- to 6-Hz tremor and cogwheel rigidity were significantly more frequent in cases without significant infarct (69%) than those with SLP (50%) and those with CWMH (12%; p < 0.05). Among cases with 4- to 6-Hz tremor and cogwheel rigidity, the frequency of patients with a reduced SNpc width and L-dopa responders did not significantly differ between those with SLP (73 and 83%, respectively) and those without significant infarct (83 and 86%, respectively), suggesting that the diagnosis for most of these cases would be probable IPD. In contrast, among cases without 4- to 6-Hz tremor and cogwheel rigidity, those with a reduced SNpc width or L-dopa responders were significantly less frequent among cases with SLP (25 and 38%, respectively) than among those without significant infarct (75 and 71%, respectively; p < 0.05). Patients with neither 4- to 6-Hz tremor and cogwheel rigidity nor reduction in the SNpc width, for whom the probable diagnosis was vascular parkinsonism (VP), were significantly more frequent in cases with SLP (26%) and with CWMH (40%) than those without significant infarct (8%), accounting for 10.6% of the total parkinsonian cases. These findings suggest that parkinsonian cases with SLP or CWMH consist of not only cases with vascular-lesion-related VP but also IPD in which vascular lesions are not directly related to parkinsonism. Absence of 4- to 6-Hz tremor, cogwheel rigidity and the reduction in the SNpc width could be indicators for differentiating VP from IPD.

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Parkinsonism and dilatation of the perivascular spaces (État Criblé) of the striatum: A clinical, magnetic resonance imaging, and pathological study

Cited by 44 publications

References 12 publications

Frequency and Location of Dilated Virchow-Robin Spaces in Elderly People: A Population-Based 3D MR Imaging Study

Frequency and Location of Dilated Virchow-Robin Spaces in Elderly People: A Population-Based 3D MR Imaging Study

Dementia and parkinsonism case secondary to giant cystic Virchow-Robin spaces

Symptomatic Characteristics of Parkinsonism and the Width of Substantia nigra pars compacta on MRI According to Ischemic Changes in the Putamen and Cerebral White Matter: Implications for the Diagnosis of Vascular Parkinsonism

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