Parkinson's Disease Risk and Alcohol Intake: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies

Shao, Chuan; Wang, Xiaoya; Wang, Pan; Tang, Hui; He, Jun; Wu, Nan

doi:10.3389/fnut.2021.709846

Cited by 9 publications

(10 citation statements)

References 46 publications

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“…This result is similar to findings in a previous meta-analysis of 11 prospective studies demonstrating that alcohol consumption was associated with decreased risk of PD. The association was nearly U-shaped ( Shao et al, 2021 ). The risk of PD decreased (smallest RR 0.81) with the amount of daily drinking.…”

Section: Discussionmentioning

confidence: 99%

“…However, previous studies on the association between alcohol and risk of PD had conflicting results. A meta-analysis, in which eleven prospective studies were included, suggested that alcohol consumption was related with a decreased risk of PD (RR 0.81, 95% CI 0.70–0.95) ( Shao et al, 2021 ). The above-mentioned Mendelian randomization study reported increased alcohol consumption had a protective effect against PD (OR 0.79, 95% CI 0.65–0.96) ( Dominguez-Baleon et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Changes in smoking, alcohol consumption, and the risk of Parkinson’s disease

Jung,

Chun,

Cho

et al. 2023

Front. Aging Neurosci.

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ObjectiveThere have been no studies on the association between changes in smoking and alcohol consumption or combined changes in smoking and alcohol consumption frequencies and PD risk. To assess the influence of changes in smoking and alcohol consumption on the risk of Parkinson’s disease (PD).MethodsNational Health Insurance Service (NHIS) database between January 2009 to December 2011 was analyzed. A total of 3,931,741 patients were included. Study participants were followed up for the incidence of PD until December 2017.ResultsCompared to the sustained non-smokers, sustained light smokers (adjusted hazard ratio [aHR] 0.80, 95% confidence interval [CI] 0.75–0.85), sustained moderate smokers (aHR 0.54, 95% CI 0.47–0.61), and sustained heavy smokers (aHR 0.49, 95% CI 0.44–0.55) had a lower risk of PD. Compared to those who sustained non-drinking, sustained light drinkers (aHR 0.85 95% CI 0.89–0.91), sustained moderate drinkers (aHR 0.68, 95% CI 0.60–0.78), and sustained heavy drinkers (aHR 0.77, 95% CI 0.68–0.87) showed decreased risk of PD. Among non-drinkers, those who started drinking to a light level were at decreased risk of PD (aHR 0.84, 95% CI 0.77–0.91). Among non-smoking and non-drinking participants, those who initiated smoking only (aHR 0.78, 95% CI 0.70–0.86), drinking only (aHR 0.77, 95% CI 0.68–0.87), and both smoking and drinking (aHR 0.69, 95% CI 0.58–0.82) showed decreased risk of PD.ConclusionSmoking is associated with decreased risk of PD with a dose–response relationship. Alcohol consumption at a light level may also be associated with decreased risk of PD. Further studies are warranted to find the possible mechanisms for the protective effects of smoking and drinking on PD, which may present insights into the etiology of PD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Changes in smoking, alcohol consumption, and the risk of Parkinson’s disease

Jung,

Chun,

Cho

et al. 2023

Front. Aging Neurosci.

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“…Previous studies evaluating the relationship between alcohol intake and PD risk have shown contrasting results [ 43 , 44 ]. However, recent studies reported that alcohol consumption at a light to moderate level is associated with a decreased risk of PD, whereas heavy drinking is not [ 45 , 46 ]. Therefore, the quantity of alcohol consumed is important for decreasing PD risk.…”

Section: Discussionmentioning

confidence: 99%

“…The PD-related variables included diabetes mellitus [ 20 ], hypertension [ 21 ], dementia [ 22 ], stroke [ 23 ], smoking [ 24 ], alcohol use [ 25 ], and BMI [ 26 ]. Excluding the variable used for matching, the following four variables were included as potential confounders: calendar year of the index date, CCI, smoking status, and alcohol consumption.…”

Section: Methodsmentioning

confidence: 99%

Potential risk of proton pump inhibitors for Parkinson’s disease: A nationwide nested case-control study

Hong,

Jung,

Lee

et al. 2023

PLoS ONE

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Proton pump inhibitor (PPI) use is a potential risk factor for neurodegenerative disease development; however, its role in Parkinson’s disease (PD) remains unclear. This study aimed to investigate the association between PPI use and PD risk. A total of 31,326 patients with newly diagnosed PD were matches by age, sex, body mass index, diabetes, and hypertension with 125,304 controls at a ratio of 1:4. The data were collected from the Korean National Health Insurance Services Database from January 2010 to December 2019. Cumulative defined daily doses of PPIs were extracted from treatment claims. We examined the association between PPI use and PD risk using conditional logistic regression. To prevent protopathic bias, we excluded patients diagnosed with PD within a 1-year lag period after PPI exposure. We applied 2- and 3-year lag periods for sensitivity analysis. PPI use was associated with an increased risk of PD when a 1-year lag period was applied between PPI exposure and PD development (adjusted odds ratio, 1.10; 95% confidence interval, 1.07–1.13). A significant positive dose-response relationship existed between the cumulative defined daily doses of PPIs and PD development (P<0.001). Similar results were obtained for the 2- or 3-year lag periods. The association did not vary based on gender. Older age, a higher Charlson Comorbidity Index score, no alcohol consumption, and a non-smoking status were associated with a significantly increased PD risk with PPI use. We observed an association between PPI use and PD risk, although long-term follow-up studies are necessary to verify this association.

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“…We selected potential covariates based on prior studies on air pollutants and PD. 21 , 25 , 29 , 42 Covariates were assessed from the study enrollment questionnaire, including demographics [i.e., age, self-reported race and ethnicity (non-Hispanic white, non-Hispanic black, and others, including American Indian or Alaska Native, Asian, Native Hawaiian or Other Pacific Islander, and all those of Hispanic ethnicity regardless of race), 43 , 44 and educational attainment (high school or below, some college or bachelor’s degree, and graduate degree)] 44 – 46 ; lifestyle factors [i.e., body mass index (BMI) (

), 47 , 48 smoking status (never, former, and current smoker), 49 – 51 alcohol consumption status (current vs. noncurrent drinker), 51 , 52 daily caffeine intake (quartiles), 53 and physical activity (metabolic equivalent-hours/week for all activities)]; geographic covariates [i.e., US national percentile of block group area deprivation index (2000) defined by percentiles (ADI,

, and

percentile), 54 , 55 US census region (Northeast, Midwest, South, and West), 56 , 57 and residential area type (rural, small town, suburban, and urban)] 57 , 58 ; and finally self-reported health status as a surrogate for general health and comorbidities (excellent, very good or good, and fair or poor). Age at baseline was used in all analyses as a continuous variable.…”

Section: Methodsmentioning

confidence: 99%

Air Pollutants and Risk of Parkinson’s Disease among Women in the Sister Study

Cao,

Yuan,

White

et al. 2024

Environ Health Perspect

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Background: Air pollutants may contribute to the development of Parkinson’s disease (PD), but empirical evidence is limited and inconsistent. Objectives: This study aimed to prospectively investigate the associations of PD with ambient exposures to fine particulate matter with aerodynamic diameter ( ) and nitrogen dioxide ( ). Methods: We analyzed data from 47,108 US women from the Sister Study, enrolled from 2003–2009 (35–80 years of age) and followed through 2018. Exposures of interest included address-level ambient and in 2009 and their cumulative averages from 2009 to PD diagnosis with varying lag-years. The primary outcome was PD diagnosis between 2009 and 2018 ( ). We used multivariable Cox proportional hazards and time-varying Cox models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: exposure in 2009 was associated with PD risk in a dose-response manner. The HR and 95% CI were 1.22 (95% CI: 1.03, 1.46) for one interquartile [4.8 parts per billion (ppb)] increment in , adjusting for age, race and ethnicity, education, smoking status, alcohol drinking, caffeine intake, body mass index, physical activity, census region, residential area type, area deprivation index (ADI), and self-reported health status. The association was confirmed in secondary analyses with time-varying averaged cumulative exposures. For example, the multivariable adjusted HR for PD per increment in was 1.25 (95% CI: 1.05, 1.50) in the 2-year lag analysis using cumulative average exposure. Post hoc subgroup analyses overall confirmed the association. However, statistical interaction analyses found that the positive association of with PD risk was limited to women in urban, rural, and small town areas and women with percentile ADI but not among women from suburban areas or areas with percentile ADI. In contrast, exposure was not associated with PD risk with the possible exception for women from the Midwest region of the US ( , 95% CI: 1.20, 5.14) but not in other census regions. Discussion: In this nationwide cohort of US women, higher level exposure to ambient is associated with a greater risk of PD. This finding needs to be independently confirmed and the underlying mechanisms warrant further investigation. https://doi.org/10.1289/EHP13009

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Parkinson's Disease Risk and Alcohol Intake: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies

Cited by 9 publications

References 46 publications

Changes in smoking, alcohol consumption, and the risk of Parkinson’s disease

Changes in smoking, alcohol consumption, and the risk of Parkinson’s disease

Potential risk of proton pump inhibitors for Parkinson’s disease: A nationwide nested case-control study

Air Pollutants and Risk of Parkinson’s Disease among Women in the Sister Study

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