Parkinson’s disease related alterations in cannabinoid transmission

Soti, Monavareh; Ranjbar, Hoda; Kohlmeier, Kristi A.; Shabani, Mohammad

doi:10.1016/j.brainresbull.2021.11.009

Cited by 4 publications

(3 citation statements)

References 253 publications

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“…An association has been established between PD-related motor and cognitive impairments and an imbalance in excitatory and inhibitory neurotransmitter systems [ [4] , [5] , [6] ]. The primary cause of this neurodegenerative disorder is the demise or impairment of dopamine (DA)-secreting neurons in the substantia nigra pars compacta (SNc), according to multiple studies.…”

Section: Introductionmentioning

confidence: 99%

Abscisic acid ameliorates motor disabilities in 6-OHDA-induced mice model of Parkinson's disease

Shabani

Soti

Ranjbar

et al. 2023

Heliyon

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Section: Introductionmentioning

confidence: 99%

Abscisic acid ameliorates motor disabilities in 6-OHDA-induced mice model of Parkinson's disease

Shabani

Soti

Ranjbar

et al. 2023

Heliyon

Self Cite

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“…Nowadays, cannabinoids are well‐known pharmacological effectors that can be utilized as analgesics, hypnotics, and appetite inducers (Mahmoudinoodezh et al, 2022; Malhotra et al, 2021; Peyton et al, 2021). Moreover, for the past three decades, cannabinoids have evolved as potential drugs that can be utilized to treat depression and several neurodegenerative diseases such as Parkinson's, Alzheimer's, and various forms of epilepsy (Ebrahimi‐Ghiri & Khakpai, 2021; Montero et al, 2021; Pérez‐Olives et al, 2021; Salami et al, 2020; Soti et al, 2022).…”

Section: Cannabinoids and Their Potential Therapeutic Effects In Mela...mentioning

confidence: 99%

Rationalizing a prospective coupling effect of cannabinoids with the current pharmacotherapy for melanoma treatment

Bachari,

Nassar,

Schanknecht

et al. 2023

WIREs Mechanisms of Disease

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Melanoma is one of the leading fatal forms of cancer, yet from a treatment perspective, we have minimal control over its reoccurrence and resistance to current pharmacotherapies. The endocannabinoid system (ECS) has recently been accepted as a multifaceted homeostatic regulator, influencing various physiological processes across different biological compartments, including the skin. This review presents an overview of the pathophysiology of melanoma, current pharmacotherapy used for treatment, and the challenges associated with the different pharmacological approaches. Furthermore, it highlights the utility of cannabinoids as an additive remedy for melanoma by restoring the balance between downregulated immunomodulatory pathways and elevated inflammatory cytokines during chronic skin conditions as one of the suggested critical approaches in treating this immunogenic tumor.This article is categorized under: Cancer > Molecular and Cellular Physiology

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“…Several alterations of the ECS in PD have been described [ 45 , 184 ]. Whether these modifications are compensatory and meant to limit the effects of dopamine loss in the BG or whether they contribute to the development of the motor symptoms in PD is still a matter of extensive debate, but the use of cannabinoids as a therapeutic option for this condition has become of interest [ 45 , 185 ].…”

Section: The Interplay Between Cannabinoid System and Age-related Dis...mentioning

confidence: 99%

The Therapeutic Potential of the Endocannabinoid System in Age-Related Diseases

et al. 2022

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The endocannabinoid system (ECS) dynamically regulates many aspects of mammalian physiology. ECS has gained substantial interest since growing evidence suggests that it also plays a major role in several pathophysiological conditions due to its ability to modulate various underlying mechanisms. Furthermore, cannabinoids, as components of the cannabinoid system (CS), have proven beneficial effects such as anti-inflammatory, immunomodulatory, neuromodulatory, antioxidative, and cardioprotective effects. In this comprehensive review, we aimed to describe the complex interaction between CS and most common age-related diseases such as neuro-degenerative, oncological, skeletal, and cardiovascular disorders, together with the potential of various cannabinoids to ameliorate the progression of these disorders. Since chronic inflammation is postulated as the pillar of all the above-mentioned medical conditions, we also discuss in this paper the potential of CS to ameliorate aging-associated immune system dysregulation.

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Parkinson’s disease related alterations in cannabinoid transmission

Cited by 4 publications

References 253 publications

Abscisic acid ameliorates motor disabilities in 6-OHDA-induced mice model of Parkinson's disease

Abscisic acid ameliorates motor disabilities in 6-OHDA-induced mice model of Parkinson's disease

Rationalizing a prospective coupling effect of cannabinoids with the current pharmacotherapy for melanoma treatment

The Therapeutic Potential of the Endocannabinoid System in Age-Related Diseases

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