Parkinson’s Disease Patients Show Long-term Gait Improvements After Active Assistive Forced Exercise Training

Stuckenschneider, Tim; Helmich, Ingo; Raabe-Oetker, A.; Feodoroff, Boris; Froböse, Ingo; Schneider, Stefan

doi:10.1249/01.mss.0000487954.94993.25

Cited by 2 publications

(1 citation statement)

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“…Additionally, restricting the diet of 3-month-old male Sprague Dawley rats to an alternate day feeding regimen compared to ad libitum increased BDNF levels in multiple brain regions including the cortex, striatum, and hippocampus [ 213 ]. There also is a wealth of data suggesting that exercise provides neuroprotection in multiple animal models of PD [ 216 , 217 , 218 , 219 , 220 , 221 , 222 ] with additional indications that it improves motor symptoms and quality of life in individuals with PD [ 223 , 224 , 225 ]. Studies using heterozygous deletion of BDNF [ 226 ] or inhibition of BDNF TrkB receptors [ 227 ] demonstrate that BDNF is essential for the beneficial effects of exercise on the neuroprotection of the nigrostriatal DA system in PD rodent models.…”

Section: Targeting Bdnf In the Brain: Therapeutic Challenges And Pote...mentioning

confidence: 99%

New Frontiers in Neurodegeneration and Regeneration Associated with Brain-Derived Neurotrophic Factor and the rs6265 Single Nucleotide Polymorphism

Szarowicz

Steece‐Collier

Caulfield

2022

IJMS

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Brain-derived neurotrophic factor is an extensively studied neurotrophin implicated in the pathology of multiple neurodegenerative and psychiatric disorders including, but not limited to, Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, traumatic brain injury, major de-pressive disorder, and schizophrenia. Here we provide a brief summary of current knowledge on the role of BDNF and the common human single nucleotide polymorphism, rs6265, in driving the pathogenesis and rehabilitation in these disorders, as well as the status of BDNF-targeted therapies. A common trend has emerged correlating low BDNF levels, either detected within the central nervous system or peripherally, to disease states, suggesting that BDNF replacement therapies may hold clinical promise. In addition, we introduce evidence for a distinct role of the BDNF pro-peptide as a biologically active ligand and the need for continuing studies on its neurological function outside of that as a molecular chaperone. Finally, we highlight the latest research describing the role of rs6265 expression in mechanisms of neurodegeneration as well as paradoxical advances in the understanding of this genetic variant in neuroregeneration. All of this is discussed in the context of personalized medicine, acknowledging there is no “one size fits all” therapy for neurodegenerative or psychiatric disorders and that continued study of the multiple BDNF isoforms and genetic variants represents an avenue for discovery ripe with therapeutic potential.

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Section: Targeting Bdnf In the Brain: Therapeutic Challenges And Pote...mentioning

confidence: 99%

New Frontiers in Neurodegeneration and Regeneration Associated with Brain-Derived Neurotrophic Factor and the rs6265 Single Nucleotide Polymorphism

Szarowicz

Steece‐Collier

Caulfield

2022

IJMS

View full text Add to dashboard Cite

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Combining physical & cognitive training with iPSC-derived dopaminergic neuron transplantation promotes graft integration & better functional outcome in parkinsonian marmosets

Daadi,

et al. 2024

Experimental Neurology

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Parkinson’s Disease Patients Show Long-term Gait Improvements After Active Assistive Forced Exercise Training

Cited by 2 publications

References 0 publications

New Frontiers in Neurodegeneration and Regeneration Associated with Brain-Derived Neurotrophic Factor and the rs6265 Single Nucleotide Polymorphism

New Frontiers in Neurodegeneration and Regeneration Associated with Brain-Derived Neurotrophic Factor and the rs6265 Single Nucleotide Polymorphism

Combining physical & cognitive training with iPSC-derived dopaminergic neuron transplantation promotes graft integration & better functional outcome in parkinsonian marmosets

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