Parkinson's disease

Schwab, Robert S.; England, Albert C.

doi:10.1016/0021-9681(58)90006-7

Cited by 66 publications

(28 citation statements)

References 9 publications

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“…27 The results showed that for SF-36 physical component scores of HRQoL, among nine chronic diseases or conditions, only spinal cord injuries had a worse impact than PD (32.38 versus 32.72) (see Various classic studies have shown that as PD increases in severity, HRQoL worsens. 28,29 Studies in Finland, Norway and the UK have shown an inverse correlation between HRQoL and PD severity and that disability, motor (decreased mobility, instability and falls) and non-motor symptoms (depression, fatigue, pain and cognition) directly affect HRQoL. [30][31][32] The impact of the disease was further emphasised in a study of 227 patients with PD: health and HRQoL, as determined using the SF-36 health survey, was substantially worse than in the general population.…”

Section: What Is Quality Of Life and What Scales Are Used In Parkinsomentioning

confidence: 99%

Quality of Life in Parkinson’s Disease – Patient, Clinical and Research Perspectives

Stocchi¹,

Martinez‐Martín

Reichmann

2014

European Neurological Review

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Parkinson's disease (PD) has a severely negative impact on the quality of life (QoL) of patients and their caregivers. Health-related QoL (HRQoL) is a patient-reported component of QoL that includes physical, mental and social domains and in PD is an increasingly important part of patient monitoring. HRQoL in PD is assessed using a range of different generic (e.g. Short Form-36) and PD-specific (e.g. 39-item Parkinson's Disease Questionnaire) instruments/questionnaires. It is important that HRQoL is regularly determined in patients with PD to identify determinants of their HRQoL deterioration and appropriately manage them. The perspectives of PD patients, clinicians and researchers, however, can be different. In PD, motor symptoms such as slowness or tremor are the most visible manifestations of the disease and these tend to be concentrated on by doctors. PD patients, however, are likely to also have a range of non-motor symptoms such as nocturia, urinary frequency, fatigue, drooling and forgetfulness, which can be more troubling than motor symptoms. These can increase distress and social isolation but are often unreported or overlooked. In addition, morning akinesia and wearing-off phenomena may cause additional difficulty. However, these symptoms and patient concerns can be readily identified using simple HRQoL measures. The management of PD should therefore take into account patient, clinical and research perspectives of HRQoL in order to recognise and adequately address the consequences of motor and non-motor symptoms in PD.

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Section: What Is Quality Of Life and What Scales Are Used In Parkinsomentioning

confidence: 99%

Quality of Life in Parkinson’s Disease – Patient, Clinical and Research Perspectives

Stocchi¹,

Martinez‐Martín

Reichmann

2014

European Neurological Review

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“…Constipation has been identified as a rather frequent symptom in patients with Parkinson's disease ever since the first description of the disease [19][20][21][22][23][24][25][26][27][28][29][30]. Today, constipation is considered the most common manifestation of autonomic dysfunction in this disease occurring at a prevalence in the range of 70 to 80% [20][21][22][23][31][32][33][34][35].…”

Section: Lower Gi-tractmentioning

confidence: 99%

Gastrointestinal dysfunction in Parkinson's Disease

Jost

2010

Journal of the Neurological Sciences

185

129

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“…This conclusion is supported by some of the motor symptoms found in patients with basal ganglia disorders. For example, the classical symptoms of Parkinson's disease include plastic rigidity of the wrist, loss of dexterity in fine finger movement, finger tremor, and micrographia (Schwab and England, 1958). In fact, Schwab and England (1958) indicate that some of the earliest symptoms of this disorder are "peculiar and occasional involuntary posture-holding in a hand" and "loss of usual dexterity with a previously learned motor skill" (p. 494).…”

Section: Vplo and Vlo Projections To Primary Motor Cortexmentioning

confidence: 99%

The origin of thalamic inputs to the "hand" representation in the primary motor cortex

1991

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We used retrograde transport of WGA-HRP to examine the origin of thalamic inputs to the “hand” representation in the primary motor cortex of macaques (Macaca nemestrina). Injections were placed in either the crest of the precentral gyrus or the rostral bank of the central sulcus. The sites for injection in the sulcus were determined by using intracortical stimulation to map the location of hand representation. We found that the precentral gyrus and central sulcus receive their predominant input from different subdivisions of the ventrolateral thalamus. Ventralis posterior lateralis pars oralis (VPLo) provides the most substantial input to a portion of the hand representation on the gyrus. In contrast, Ventralis lateralis pars oralis (VLo) provides the most substantial input to a portion of the hand representation in the sulcus. Prior studies have shown that VPLo is a major site of termination of cerebellar efferents and that VLo is a major site of termination of pallidal efferents. Thus, our results indicate that both the basal ganglia and the cerebellum “directly” influence the “hand” representation of the primary motor cortex.

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Parkinson's disease

Cited by 66 publications

References 9 publications

Quality of Life in Parkinson’s Disease – Patient, Clinical and Research Perspectives

Quality of Life in Parkinson’s Disease – Patient, Clinical and Research Perspectives

Gastrointestinal dysfunction in Parkinson's Disease

The origin of thalamic inputs to the "hand" representation in the primary motor cortex

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