Parkinson’s Disease Is Associated With Dysregulation of Circulatory Levels of lncRNAs

Tamizkar, Kasra Honarmand; Gorji, Pooneh; Gholipour, Mahdi; Hussen, Bashdar Mahmud; Mazdeh, Mehrdokht; Eslami, Solat; Taheri, Mohammad; Ghafouri‐Fard, Soudeh

doi:10.3389/fimmu.2021.763323

Cited by 11 publications

(7 citation statements)

References 32 publications

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“…Regarding the relationship of linc-ROR with mental and neurodegenerative diseases, little evidence has also been reported. Tamiskar et al [ 79 ] measured expression levels of several lncRNAs in the circulation of Parkinson’s disease patients to try to establish a possible correlation; linc-ROR was higher in PD patients compared with controls, revealing linc-ROR dysregulation. A similar study in schizophrenia patients revealed the presence of a sex-based dysregulation of lncRNAs when compared with healthy subjects, with linc-ROR upregulated and correlated with age [ 80 ].…”

Section: Linc-ror In Diseasementioning

confidence: 99%

Functional Relevance of the Long Intergenic Non-Coding RNA Regulator of Reprogramming (Linc-ROR) in Cancer Proliferation, Metastasis, and Drug Resistance

Peña-Flores

Enríquez-Espinoza

Muela-Campos

et al. 2023

ncRNA

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Cancer is responsible for more than 10 million deaths every year. Metastasis and drug resistance lead to a poor survival rate and are a major therapeutic challenge. Substantial evidence demonstrates that an increasing number of long non-coding RNAs are dysregulated in cancer, including the long intergenic non-coding RNA, regulator of reprogramming (linc-ROR), which mostly exerts its role as an onco-lncRNA acting as a competing endogenous RNA that sequesters micro RNAs. Although the properties of linc-ROR in relation to some cancers have been reviewed in the past, active research appends evidence constantly to a better comprehension of the role of linc-ROR in different stages of cancer. Moreover, the molecular details and some recent papers have been omitted or partially reported, thus the importance of this review aimed to contribute to the up-to-date understanding of linc-ROR and its implication in cancer tumorigenesis, progression, metastasis, and chemoresistance. As the involvement of linc-ROR in cancer is elucidated, an improvement in diagnostic and prognostic tools could promote and advance in targeted and specific therapies in precision oncology.

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Section: Linc-ror In Diseasementioning

confidence: 99%

Functional Relevance of the Long Intergenic Non-Coding RNA Regulator of Reprogramming (Linc-ROR) in Cancer Proliferation, Metastasis, and Drug Resistance

Peña-Flores

Enríquez-Espinoza

Muela-Campos

et al. 2023

ncRNA

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“…These results indicate the potential role of circulating lncRNAs as treatment markers for PD. However, none of these lncRNA expressions were related to patient age, disease stage, Mini-Mental State Examination scores, or Unified Parkinson’s Disease Rating Scale scores [ 56 ].…”

Section: Lncrnamentioning

confidence: 99%

The Role of Non-Coding RNAs in the Pathogenesis of Parkinson’s Disease: Recent Advancement

et al. 2022

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Parkinson’s disease (PD) is a prevalent neurodegenerative aging disorder that manifests as motor and non-motor symptoms, and its etiopathogenesis is influenced by non-coding RNAs (ncRNAs). Signal pathway and gene sequence studies have proposed that alteration of ncRNAs is relevant to the occurrence and development of PD. Furthermore, many studies on brain tissues and body fluids from patients with PD indicate that variations in ncRNAs and their target genes could trigger or exacerbate neurodegenerative pathogenesis and serve as potential non-invasive biomarkers of PD. Numerous ncRNAs have been considered regulators of apoptosis, α-syn misfolding and aggregation, mitochondrial dysfunction, autophagy, and neuroinflammation in PD etiology, and evidence is mounting for the determination of the role of competing endogenous RNA (ceRNA) mechanisms in disease development. In this review, we discuss the current knowledge regarding the regulation and function of ncRNAs as well as ceRNA networks in PD pathogenesis, focusing on microRNAs, long ncRNAs, and circular RNAs to increase the understanding of the disease and propose potential target identification and treatment in the early stages of PD.

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“…PVT1 could be used as a prognostic marker of prostate cancer as higher levels are associated with an advanced tumor stage and poor overall and disease-free rates of survival [ 202 ]. lncRNA PVT1 has been reported to be involved in the pathogenesis of PD [ 203 ]. Reduced expression of PVT1 has recently been found in patients with PD, and this downregulation was responsible for modulation of the epidermal growth factor receptor pathway, resulting in the induction of apoptosis and inhibition of the cell cycle [ 203 ].…”

Section: Ncrna In Prostate Cancer and Neurodegenerative Diseasesmentioning

confidence: 99%

“…lncRNA PVT1 has been reported to be involved in the pathogenesis of PD [ 203 ]. Reduced expression of PVT1 has recently been found in patients with PD, and this downregulation was responsible for modulation of the epidermal growth factor receptor pathway, resulting in the induction of apoptosis and inhibition of the cell cycle [ 203 ].…”

Section: Ncrna In Prostate Cancer and Neurodegenerative Diseasesmentioning

confidence: 99%

Examples of Inverse Comorbidity between Cancer and Neurodegenerative Diseases: A Possible Role for Noncoding RNA

Salemi

Mogavero

Lanza

et al. 2022

Cells

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Cancer is one of the most common causes of death; in parallel, the incidence and prevalence of central nervous system diseases are equally high. Among neurodegenerative diseases, Alzheimer’s dementia is the most common, while Parkinson’s disease (PD) is the second most frequent neurodegenerative disease. There is a significant amount of evidence on the complex biological connection between cancer and neurodegeneration. Noncoding RNAs (ncRNAs) are defined as transcribed nucleotides that perform a variety of regulatory functions. The mechanisms by which ncRNAs exert their functions are numerous and involve every aspect of cellular life. The same ncRNA can act in multiple ways, leading to different outcomes; in fact, a single ncRNA can participate in the pathogenesis of more than one disease—even if these seem very different, as cancer and neurodegenerative disorders are. The ncRNA activates specific pathways leading to one or the other clinical phenotype, sometimes with obvious mechanisms of inverse comorbidity. We aimed to collect from the existing literature examples of inverse comorbidity in which ncRNAs seem to play a key role. We also investigated the example of mir-519a-3p, and one of its target genes Poly (ADP-ribose) polymerase 1, for the inverse comorbidity mechanism between some cancers and PD. We believe it is very important to study the inverse comorbidity relationship between cancer and neurodegenerative diseases because it will help us to better assess these two major areas of human disease.

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Parkinson’s Disease Is Associated With Dysregulation of Circulatory Levels of lncRNAs

Cited by 11 publications

References 32 publications

Functional Relevance of the Long Intergenic Non-Coding RNA Regulator of Reprogramming (Linc-ROR) in Cancer Proliferation, Metastasis, and Drug Resistance

Functional Relevance of the Long Intergenic Non-Coding RNA Regulator of Reprogramming (Linc-ROR) in Cancer Proliferation, Metastasis, and Drug Resistance

The Role of Non-Coding RNAs in the Pathogenesis of Parkinson’s Disease: Recent Advancement

Examples of Inverse Comorbidity between Cancer and Neurodegenerative Diseases: A Possible Role for Noncoding RNA

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