Parkinson’s disease in China: a forty-year growing track of bedside work

Li, Gen; Ma, Jianfang; Cui, Shishuang; He, Yanfang; Xiao, Qin; Li, Jun; Chen, Shengdi

doi:10.1186/s40035-019-0162-z

Cited by 102 publications

(94 citation statements)

References 63 publications

(57 reference statements)

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“…Parkinson's disease (PD) is the second common neurodegenerative disease. The average prevalence of PD in China was about 3.8756‰ (≥50 years) in Han population, bringing a huge burden to Chinese economics and healthcare system [1]. The clinical presentation and course of Parkinson's disease (PD) is heterogeneous, with variability in onset, progression, motor and non-motor symptoms.…”

Section: Backgroundsmentioning

confidence: 99%

The association between clinical phenotype of Parkinson’s disease and LRRK2 variants in China

Cui

Lin

et al. 2020

Preprint

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Introduction: LRRK2 G2385R and LRRK2 S1647T have been identified as the most common risk variants for PD in the Chinese population. The aim of the study was to explore the correlation of LRRK2 G2385R, LRRK2 S1647T and their haplotypes with symptoms. Method: Demographic variables, disease-related variables and motor and non-motor assessments was collected in the study. Peripheral blood samples were collected, and DNA was extracted. SNaPShot technique was used to analysis DNA genotype. Chi square test and ANOVA was used to test the between-group differences. Risk analysis was performed by logistic regression model or Cochran-Armitage model. Results: 502 PD patients were enrolled in the study. The scores of PDSS and MoCA were significant higher in LRRK2 S1647T variants carriers genotype after adjustment. The scores of BPI, attention in NMSS, cardiovascular in SCOPA-AUT was significant lower in LRRK2 G2385R variants carriers adjusted for H-Y stage and gender. LRRK2 ARG 2385 was associated with reduced risk of sialorrhea (p=0.049, additive model) and postural hypotension (p=0.030, additive model; OR=0.35, 95%CI: 0.10-0.89, adjusted P=0.050, dominant model). rs11564148A rs34778348A was also found associated with a reduced risk with postural hypotension adjusted for H-Y staging and gender. Conclusion: Our study indicated that LRRK2 S1647T variants carriers presented better motor symptoms, sleep quality and cognition. LRRK2 G2385R variants carriers presented better autonomic function and cognition and had a reduced risk of sialorrhea and postural hypotension. rs11564148A - rs34778348A was associated with reduced risk with postural hypotension.

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Section: Backgroundsmentioning

confidence: 99%

The association between clinical phenotype of Parkinson’s disease and LRRK2 variants in China

Cui

Lin

et al. 2020

Preprint

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“…Parkinson's disease (PD) is a chronic, progressive neurodegenerative disorder. It is estimated that by 2030, Chinese PD patients will increase to 4.94 million, accounting for a half of the PD patients worldwide (Li et al, 2019). Recent advances have helped delineate the pathogenetic mechanisms, yet the etiology and pathogenesis of PD in most individuals remain obscure.…”

Section: Introductionmentioning

confidence: 99%

Hypermethylation of the Gene Coding for PGC-1α in Peripheral Blood Leukocytes of Patients With Parkinson’s Disease

Yang

Qian

et al. 2020

Front. Neurosci.

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Decreased expression of peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) is implicated in the pathophysiology of Parkinson's disease (PD). However, our understanding of the mechanism regulating the PGC-1α expression is still limited. We sought to determine whether the epigenetic modification of PPARGC1A (the gene encoding PGC-1α) could account for its diminished expression. We performed a study of PPARGC1A risk-SNP genotypes, methylation level, and the expression in blood from 171 subjects. The mean DNA methylation level of PPARGC1A intron 1 in patients with PD was higher than that in the controls (7.18 ± 1.74 vs. 6.36 ± 1.28, P = 0.007). A detailed comparison of the DNA methylation level at each CpG site showed that CpG_1, CpG_13.14, CpG_17.18, and CpG_20 were significantly hypermethylated in patients with PD. There was a significant negative correlation between PPARGC1A methylation and expression level (R = −0.404, P < 0.001). We found no correlations between the PPARGC1A methylation level and the clinical features, while the CpG_13.14 site methylation level was positively correlated with H&Y stage (R = 0.246, P = 0.020) and was increased in people carrying the rs2970848 AA genotype compared with that in carriers of the AG/GG genotype (7.27 ± 1.86 vs. 6.65 ± 1.92, P = 0.032). Our results support a link between PPARGC1A methylation, gene expression, and variability, which indicated that a novel epigenetic regulatory mechanism controlling PPARGC1A expression influences PD pathogenesis.

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“…Parkinson's disease (PD) is a progressive neurological disorder associated with the degeneration of dopamine-producing cells in the nigra [1]. Up to now, the average prevalence and incidence of Parkinson's disease (PD) in China have been 1700/100,000 (≥65 years) and 797/100,000 (per year)respectively, also, the number of PD prevalence is expected to reach about 5 million by 2030 [2][3][4].The cardinal features of PD are bradykinesia, tremors, rigidity, and postural instability [5]. Patients suffering from PD are frequently disturbed by the motor symptoms of PD in daily functions , activities, and roles [6].…”

Section: Introductionmentioning

confidence: 99%

Acceptability and practicability of self-management for patients with Parkinson's disease based on smartphone applications in China

Yuan²,

Zhao

et al. 2020

Preprint

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Background: China has had about 1.2 billion mobile-phone users, and this number continues to grow. However, mobile-health services (mHealth) are currently in the initial stage, and have not yet prevailed in China. Additionally, the prevalence of Parkinson's disease (PD) in China is 1700/100,000 (≥65 years). Indeed, these PD patients would benefit from mHealth to manage their disease. Therefore, we designed a study to determine attitudes toward smartphone applications (apps) for chronic condition self-management, and to discover the practicality of these apps among PD patients in China.Methods: We selected 204 participants with PD between 52 and 87 years old and surveyed their attitudes concerning the use of smartphone apps for chronic condition management via questionnaires. Results: Among the participants, 65.19％ had smartphones. Among these smartphone users, 82.84％ expressed a preference for using apps for PD management. This group tended to be younger and more frequent web users with higher education and better medication compliance, and they tended to have a longer PD course and worse conditions (P < 0.001, P = 0.001, P < 0.001, P = 0.041, P < 0.001, P = 0.013) .Additionally, the willingness to apply apps for PD self-management was positively related to education (P < 0.001) and negatively related to age and PD course (P = 0.017, P < 0.001). Conclusion: In China, patients with PD have a generally positive attitude towards self-management through smartphone apps. Consequently, improving the coverage of smartphones with practical and handy apps is a promising strategy for PD self-management.

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Parkinson’s disease in China: a forty-year growing track of bedside work

Cited by 102 publications

References 63 publications

The association between clinical phenotype of Parkinson’s disease and LRRK2 variants in China

The association between clinical phenotype of Parkinson’s disease and LRRK2 variants in China

Hypermethylation of the Gene Coding for PGC-1α in Peripheral Blood Leukocytes of Patients With Parkinson’s Disease

Acceptability and practicability of self-management for patients with Parkinson's disease based on smartphone applications in China

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