Parkinson's disease Improved function with GMl ganglioside treatment in a randomized placebo‐controlled study

Abstract

This study demonstrates that GM1 ganglioside treatment enhances neurologic function significantly in PD patients. Further study is warranted to evaluate long-term effects of GM1 in PD patients and to elucidate further the mechanisms underlying patient improvements.

Alzheimer Disease – Effect of Continuous Intracerebroventricular Treatment with GM1 Ganglioside and a Systematic Activation Programme

“…Our treatment schedule has been valuable for patients with AD: the disappearance of Parkinson-like symptoms in a few weeks, the significant increase in dopamine turnover and the beneficial effect of parenteral administration of GM1 to patients with Parkinson's disease [24] suggest that our treatment method will be particularly useful for patients with Parkinson's disease. It is our sincere hope that other research groups will take note of these findings and extend our observations.…”

Thematic Review Series: Sphingolipids. Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease—a review

“…GM1 treatment restored cognitive and motor function and prevented decline in function in a 90 week trial in monkeys (179). In a double-blind, placebocontrolled study, Parkinson's patients improved significantly after 16 weeks of GM1 treatment, compared with both the placebo group and their own initial baselines (180). In addition to GM1, Schneider et al (181) reported potential neuroprotective and neurorestorative roles for the synthetic ceramide analog L-threo-1-phenyl-2- decanoylamino-3-morpholino-1-propanol (L-PDMP) in mouse models of Parkinsonism.…”

High Levels of Anti-Ganglioside Antibodies in Patients with Parkinson?s Disease Associated with Cognitive Decline

“…GM1 treatment restored cognitive and motor function and prevented decline in function in a 90 week trial in monkeys. In a placebo controlled study, Parkinson's patients improved significantly after 16 weeks of GM1 treatment [77].…”