Parkinson’s disease gene, Synaptojanin1, dysregulates the basal maintenance of the dopamine transporter
Ping-Yue Pan,
Jacqueline Saenz,
Elnaz Khezerlou
et al.
Abstract:Missense mutations of PARK20/SYNJ1 (synaptojanin1/Synj1) have been linked to complex forms of familial parkinsonism, however, the molecular and cellular changes associated with dopaminergic dysfunction remains unknown. We now report fast depletion of evoked dopamine (DA) and altered maintenance of the axonal dopamine transporter (DAT) in the Synj1+/- neurons. While Synj1 has been traditionally known to facilitate the endocytosis of synaptic vesicles, we demonstrated that axons of cultured Synj1+/- neurons exhi… Show more
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