Parkinson's Disease and Tea: A Quantitative Review

Quintana, J.L. Barranco; Allam, Mohamed Farouk; Castillo, Amparo Serrano Del; Navajas, Rafael Fernández-Crehuet

doi:10.1080/07315724.2009.10719754

Cited by 47 publications

(13 citation statements)

References 42 publications

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“…The estimated summary OR is 0.85, which donates that tea drinking can decrease the risk of PD. This is consistent with the results of the similar study by Quintana et al [6] and, thus, further confirms the relation of tea consumption and PD. The mechanisms underlying the protective effects of tea drinking against PD risk should be multiple.…”

Section: Discussionsupporting

confidence: 93%

“…Many studies reported that tea drinking can lower the risk of PD [6–10, 12–15], while this protective effect of tea is not demonstrated by other groups [11, 16]. With the aim to evaluate the association between tea drinking and PD risk, a meta-analysis was conducted based on published studies.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the pathogenesis of PD is not fully elucidated, many epidemiological factors, such as coffee drinking and smoking, have been demonstrated to lower the risk of PD [3–5]. Tea is one of the most popular beverages worldwide, and the effects of tea consumption on PD risk have attracted much attention in recent years [6–17], as the tea components, such as flavonoids, caffeine, and theanine, have been proven to be neuroprotective in animal models of PD. Many studies have found that tea drinking can lower the risk of PD [6–10, 12–15], while this beneficial effect of tea is not observed in other reports [11, 16].…”

Section: Introductionmentioning

confidence: 99%

“…Tea is one of the most popular beverages worldwide, and the effects of tea consumption on PD risk have attracted much attention in recent years [6–17], as the tea components, such as flavonoids, caffeine, and theanine, have been proven to be neuroprotective in animal models of PD. Many studies have found that tea drinking can lower the risk of PD [6–10, 12–15], while this beneficial effect of tea is not observed in other reports [11, 16]. The purpose of the present study was to perform a meta-analysis to provide a comprehensive conclusion on the association between tea drinking and PD risk, which has important implications for the prevention and treatment of this disease.…”

Section: Introductionmentioning

confidence: 99%

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A Meta-Analysis of Tea Drinking and Risk of Parkinson's Disease

Shen

2012

The Scientific World Journal

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Background. Many studies have reported an association between tea drinking and Parkinson's disease (PD). Our purpose is to summarize the available information and evaluate the risk of PD associated with tea drinking. Methods. We searched all publications in English language on the association of tea drinking and PD risk published up to December 2010. The pooled analysis was performed with Review Manager 5.0. Results. In total, eight articles including 1418 cases and 4250 controls were included in the meta-analysis. The pooled odds ratio (95% CI) was 0.85 (0.74–0.98), which suggests the protective effect of tea drinking in PD risks. Moreover, the summary OR (OR: 0.83, 95% CI = 0.69–0.99) for drinkers of ≤1 cup of tea per day versus nonconsumers and that (OR: 0.96, 95% CI = 0.73–1.27) for drinkers of >1 cups of tea per day versus nonconsumers showed that there was not an apparent dose-response relationship. No indication for publication bias was found. Conclusions. This meta-analysis showed that tea drinking can lower the risk of PD, while no apparent dose-response relationship was found. Further effort is needed to fully understand the mechanism underlying the beneficial effect of tea consumption in lowering PD risk.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Meta-Analysis of Tea Drinking and Risk of Parkinson's Disease

Shen

2012

The Scientific World Journal

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“…Interestingly, epidemiological studies from China have observed that the prevalence of PD is much lower than in the Caucasian population (Li et al, 1985; Zhang et al, 1993). Barranco et al, 2009 reviewed observational studies that evaluated tea consumption and the risk of PD (11 case-control and 1 cohort) between 1981 and 2003. The studies represented documented cases from North America, Europe and Asia.…”

Section: ) Epidemiology and Clinical Trials Of Adenosine Antagonistsmentioning

confidence: 99%

Pathophysiological roles for purines

Morelli

Carta

Kachroo

et al. 2010

Progress in Brain Research

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The motor symptoms of Parkinson's disease (PD) are due primarily to the degeneration of the dopaminergic neurons in the nigrostriatal pathway. However, several other brain areas and neurotransmitters other than dopamine such as noradrenaline, 5-hydroxytryptamine and acetylcholine are affected in the disease. Moreover, adenosine because of the extensive interaction of its receptors with the dopaminergic system has been implicated in the in the pathophysiology of the disease. Based on the involvement of these nondopaminergic neurotransmitters in PD and the sometimes severe adverse effects that limit the mainstay use of dopamine-based antiparkinsonian treatments, recent assessments have called for a broadening of therapeutic options beyond the traditional dopaminergic drug arsenal. In this review we describe the interactions between dopamine and adenosine receptors that underpin the preclinical and clinical rationale for pursuing adenosine A2A receptor antagonists as symptomatic and potentially neuroprotective treatment of PD. The review will pay particular attention to recent results regarding specific A2A receptor-receptor interactions and recent findings identifying urate, the end product of purine metabolism, as a novel prognostic biomarker and candidate neuroprotectant in PD.

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Tea Polyphenols in Parkinson’s Disease

Caruana

Vassallo

2015

Advances in Experimental Medicine and Biology

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Parkinson's disease (PD) is a common motor neurodegenerative disorder with multifactorial etiology that is an increasing burden on our aging society. PD is characterized by nigrostriatal degeneration which might involve oxidative stress, α-synuclein (αS) aggregation, dysregulation of redox metal homeostasis and neurotoxicity. Although the exact cause remains unknown, both genetic and environmental factors have been implicated. Among the various environmental factors tea consumption has attracted increasing interest, as besides being one of the most consumed beverages in the world, tea contains specific polyphenols which can play an important role in delaying the onset or halting the progression of PD. Green and black teas are rich sources of polyphenols, the most abundant being epigallocatechin-3-gallate (EGCG) and theaflavins. There is now consistent mechanistic data on the neuroprotective and neuroregenerative effects of tea polyphenols, indicating that they do not just possess anti-oxidant or anti-chelating properties but may directly interfere with aggregation of the αS protein and modulate intracellular signalling pathways, both in vitro and in animal models. EGCG in green tea has been by far the most studied compound and therefore future investigations should address more the effects of other polyphenols, especially theaflavins in black tea. Nevertheless, despite significant data on their potential neuroprotective effects, clinical studies are still very limited and to date only EGCG has reached phase II trials. This review collates the current knowledge of tea polyphenols and puts into perspective their potential to be considered as nutraceuticals that target various pathologies in PD.

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Parkinson's Disease and Tea: A Quantitative Review

Abstract: Tea consumption can protect against PD and this protective effect is clearer in Chinese populations. The low rate of tea consumption among persons with PD should provide us many valuable insights into the nature of the illness.

Cited by 47 publications

References 42 publications

A Meta-Analysis of Tea Drinking and Risk of Parkinson's Disease

A Meta-Analysis of Tea Drinking and Risk of Parkinson's Disease

Pathophysiological roles for purines

Tea Polyphenols in Parkinson’s Disease

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