Parkinson's disease and intensive exercise therapy – a systematic review and meta-analysis of randomized controlled trials

Uhrbrand, Anders; Stenager, Egon; Pedersen, Martin; Dalgas, Ulrik

doi:10.1016/j.jns.2015.04.004

Cited by 156 publications

(161 citation statements)

References 80 publications

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“…Our exercise programme incorporated both aerobic and resistance exercise and combining training modalities may be important to optimise benefits 2. However, while individuals progressed, we did not observe the improvements in aerobic and resistance fitness measures that might be expected 1 2. It is therefore plausible that the improvements in motor symptoms observed might be to some extent attributable to exercise-induced neuroplasticity identified in animal models of the disease,35 rather than just improved physical capacity.…”

Section: Discussionmentioning

confidence: 70%

“…This is encouraging as systematic reviews have not established improvements in this construct despite the improvements in motor symptoms 1 2. Certainly, while systematic reviews support that exercise interventions can benefit PwP and are safe,1 2 7 38 they also confirm that the longer term effects have not been established and that pragmatic delivery models are largely untested 3–6 39 40. We propose that the intervention provides evidence for effectively supporting PwP to engage with an exercise programme for 6 months through standard community resources.…”

Section: Discussionmentioning

confidence: 99%

“…A meta-analysis of aerobic training, primarily driven by studies with short interventions and follow-ups (<16 weeks), found a pooled mean difference in MDS-UPDRS III of −0.57 (95% CI −0.95 to 0.19) in favour of exercise,1 we found a difference of −3.0±1.5, −4.0±1.4 and −1.5±1.6 at 3, 6 and 12 months, respectively. Uhrbrand et al 2 found in their review that improvements in the MSD-UPDRS III were more associated with resistance than aerobic exercise modes. Our exercise programme incorporated both aerobic and resistance exercise and combining training modalities may be important to optimise benefits 2.…”

Section: Discussionmentioning

confidence: 99%

“…Uhrbrand et al 2 found in their review that improvements in the MSD-UPDRS III were more associated with resistance than aerobic exercise modes. Our exercise programme incorporated both aerobic and resistance exercise and combining training modalities may be important to optimise benefits 2. However, while individuals progressed, we did not observe the improvements in aerobic and resistance fitness measures that might be expected 1 2.…”

Section: Discussionmentioning

confidence: 99%

“…Short-term exercise has been shown to benefit or stop deterioration in symptoms offering potential personal, societal and economic benefits for the management of Parkinson's disease (PD),1 2 but many people with Parkinson's disease (PwP) undertake less exercise than other age-matched people, and less than recommended to maintain good health 3 4. While exercise may improve health and well-being and reduce motor and non-motor symptoms in PwP,3–6 there is a lack of evidence for the long-term benefits 6–10.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Phase II randomised controlled trial of a 6-month self-managed community exercise programme for people with Parkinson's disease

Collett

Franssen

Meaney

et al. 2016

J Neurol Neurosurg Psychiatry

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Phase II randomised controlled trial of a 6-month self-managed community exercise programme for people with Parkinson's disease

Collett

Franssen

Meaney

et al. 2016

J Neurol Neurosurg Psychiatry

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Sirtuins as modifiers of Parkinson's disease pathology

Tang

2016

J of Neuroscience Research

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Parkinson's disease (PD) is the most common movement disorder associated with the elderly which, other than symptomatic therapies, has no effective treatment or preventive measures. Sirtuins and their pharmacological activators/inhibitors have been associated with a range of neuroprotective effects, and a large body of work on sirtuins' influence on PD pathology has accumulated over the past decade. Here, evidence for sirtuins' activities as modifiers of PD pathology and how the mammalian sirtuin paralogues may have conflicting impacts on PD pathogenesis and disease progression is reviewed. The possible cellular and molecular mechanisms underlying sirtuin activities in PD are discussed in the light of current knowledge with reference to autophagy, mitochondrial homeostasis, and microtubule dynamics. © 2016 Wiley Periodicals, Inc.

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Development of an Exercise‐Specific Parkinson's Disease Questionnaire: The PDQ‐Exercise

et al. 2021

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A BS TRACT: Background: Exercise is now a significant and key component in the management of Parkinson's disease. However, no self-report, Parkinson's-specific measure of exercise currently exists. Objective: To develop a patient-reported outcome measure (PROM) for use in studies and clinical trials that aim to assess the efficacy of exercise therapy for people with Parkinson's (PwP). Methods: Participants were recruited via Parkinson's UK. To generate meaningful items, PwP participated in exploratory cognitive interviews. To pretest the items generated, PwP took part in two rounds of cognitive debrief interviews. Items were subsequently tested through an online survey that also included the eight-item Parkinson's Disease Questionnaire (PDQ-8) and Oxford Participation and Activities Questionnaire (Ox-PAQ).Results: Twenty PwP were interviewed for item generation. Analyses identified issues related to adopting and maintaining exercise, resulting in the generation of 10 items. Fourteen PwP took part in subsequent cognitive debrief interviews. Following the first 10 interviews, one item was removed, and minor adjustments were made to the wording of two items. Four final interviews verified that no further adjustments were required. Consequently, nine items were included in the validation survey, which was fully completed by 398 PwP. Inspection of floor and ceiling effects resulted in the removal of two further items. A principal component analysis identified a single sevenitem factor explaining 61.6% of variance. Further analyses indicated that the measure demonstrates sound reliability and validity. Conclusions: Results indicate that the PDQ-Exercise is an acceptable, reliable, and valid PROM. Further assessment of its psychometric properties is in progress.

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Parkinson's disease and intensive exercise therapy – a systematic review and meta-analysis of randomized controlled trials

Cited by 156 publications

References 80 publications

Phase II randomised controlled trial of a 6-month self-managed community exercise programme for people with Parkinson's disease

Phase II randomised controlled trial of a 6-month self-managed community exercise programme for people with Parkinson's disease

Sirtuins as modifiers of Parkinson's disease pathology

Development of an Exercise‐Specific Parkinson's Disease Questionnaire: The PDQ‐Exercise

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