Parkinson's disease and basal ganglia calcifications: Prevalence and clinico-radiological correlations

Vermersch, Patrick; Leys, D.; Pruvo, JP; Clarisse, J; Petit, H

doi:10.1016/0303-8467(92)90091-g

Cited by 32 publications

(24 citation statements)

References 19 publications

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“…It is evident that amount of iron in brain gradually grows with age. Accumulation of iron in basal ganglia is probably associated with neuronal death leading to Alzheimer disease, Parkinson disease, epilepsy, Huntington disease, dementia with Lewy bodies, and multiple sclerosis [4][5][6][7][8]. It was reported that iron participates in redox reactions, and catalyzes the formation of reactive oxygen species responsible for oxidative stress and damaging processes [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Properties of Iron Oxides in the Human Globus pallidus

Kopáni¹,

Hlinkova²,

Ehrlich³

et al. 2017

J Bioanal Biomed

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Postmortem brain tissue sections from Globus pallidus externus were routinely obtained during the autopsy to prepare tissue sections for the pathology diagnosis at Department of pathology, Comenius University, Bratislava. Tissues were taken from individuals without clinical findings of any motor abnormalities, iron metabolism, movements involving limbs, face, and tongues (Table 1). All procedures were conducted in accordance with the Declaration of Helsinki. AbstractSeveral types of iron oxides can be found in the various parts of the human brain. These can be highlighted in the light microscopy and using scanning or transmission mode of the electron microscopy. Some of them are non-magnetic, some, on the contrary, display magnetic response. It is not clear which kind of magnetic particles are accumulated in the human brain as inorganic deposits. Light microscopy, electron microscopy and sensitive Superconducting Quantum Interference Device (SQUID magnetometer) were used in order to detect iron deposits and their magnetic response in the samples extracted from the Globus pallidus of the human brain. Electron microscopy reveals a presence of the single crystals of hematite (α-Fe 2 O 3 ) of the size up to 1000 nm in the samples extracted from G. pallidus because of the diffractograms characteristic for the hexagonal unit cell; this mineral offers basically a diamagnetic response. The temperature dependence of the magnetic susceptibility allows a classification of the samples into three groups: mostly diamagnetic I, prevailing paramagnetic III, and an intermediate class II. The bulk samples exhibit a long-range magnetic ordering with magnetic hysteresis evidenced not only at low temperature but also at the room temperature. The recorded magnetic functions refer either to the presence of magnetite (Fe 3 O 4 ), or maghemite (γ-Fe 2 O 3 ). Iron oxides and oxidohydroxides found as inorganic deposits in the human brain can result from interaction between iron and microenvironment in the form of polysaccharides of glycoconjugates. They display magnetoactivity characteristic for magnetite and/or maghemite.

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Section: Introductionmentioning

confidence: 99%

Magnetic Properties of Iron Oxides in the Human Globus pallidus

Kopáni¹,

Hlinkova²,

Ehrlich³

et al. 2017

J Bioanal Biomed

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“…Iron accumulation [10][11][12][13] in the brain occurs in PD, and measuring the amount of nonheme iron in the body may not only lead to a better understanding of the disease progression, but also help to predict the outcome in relation to patients' motor symptom.…”

Section: Introductionmentioning

confidence: 99%

Determination of brain iron content in patients with Parkinson’s disease using magnetic susceptibility imaging

et al. 2009

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Objective To compare the phase radians in several cerebral regions between patients with Parkinson's disease (PD) and control subjects, and to evaluate whether iron deposition quantified by susceptibility-weighted imaging (SWI) is related to the severity of motor symptoms of PD. Methods SWI consisted of both magnitude and phase images from a fully flow-compensated, 3-dimensional and gradient-echo (GRE) sequence. Magnitude and phase data were collected at GE HD 1.5T.The regions evaluated included frontal white matter, grey matter, cerebrospinal fluid, putamen, caudate nucleus (CN), substantia nigra pars compacta (SNc), substantia nigra pars reticulata (SNr), and red nucleus (RN). A total number of 42 patients (12 patients without cognitive dysfunction, and 30 with cognitive dysfunction from mild to moderate degrees) and 30 control subjects were employed in the present study. Results The phase radians of SNc, CN and RN in PD patients were lower than those in control subjects (P<0.05). Conclusion The phase radians can be used to estimate the brain iron deposition in PD patients, which may be helpful in the diagnosis and longitudinal monitoring of PD.

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“…8,9 More recently, with MR imaging, T2 shortening in the gray matter nuclei with age has been well documented. [10][11][12][13][14] A reduction in T2 is thought to be predominantly related to iron deposition, particularly ferritin, 2,11,15 though 1 team 16 reports contrary findings.…”

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confidence: 99%