Parkinson's disease and atypical parkinsonism: the importance of magnetic resonance imaging as a potential biomarker

Carrete, Henrique

doi:10.1590/0100-3984.2017.50.4e1

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…Blood-based biomarkers are important for their applicability in clinical practice, for tracing of individuals at risk (especially among patient relatives), early diagnosis, and prognosis. Furthermore, in the case of neurodegenerative disorders, it is common to observe the overlapping of symptoms leading to additional complexity in identifying the disease [ 12 , 134 ]. Hence, circulating biomarkers may be helpful for differential diagnosis among neurological diseases, and the deregulation of ncRNAs such as miRNAs is a potential source of these biomarkers.…”

Section: Epigenetic Alterations In Parkinson’s Diseasementioning

confidence: 99%

Nuclear and Mitochondrial Genome, Epigenome and Gut Microbiome: Emerging Molecular Biomarkers for Parkinson’s Disease

Cabral

Schaan

Cavalcante

et al. 2021

IJMS

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Background: Parkinson’s disease (PD) is currently the second most common neurodegenerative disorder, burdening about 10 million elderly individuals worldwide. The multifactorial nature of PD poses a difficult obstacle for understanding the mechanisms involved in its onset and progression. Currently, diagnosis depends on the appearance of clinical signs, some of which are shared among various neurologic disorders, hindering early diagnosis. There are no effective tools to prevent PD onset, detect the disease in early stages or accurately report the risk of disease progression. Hence, there is an increasing demand for biomarkers that may identify disease onset and progression, as treatment-based medicine may not be the best approach for PD. Over the last few decades, the search for molecular markers to predict susceptibility, aid in accurate diagnosis and evaluate the progress of PD have intensified, but strategies aimed to improve individualized patient care have not yet been established. Conclusions: Genomic variation, regulation by epigenomic mechanisms, as well as the influence of the host gut microbiome seem to have a crucial role in the onset and progress of PD, thus are considered potential biomarkers. As such, the human nuclear and mitochondrial genome, epigenome, and the host gut microbiome might be the key elements to the rise of personalized medicine for PD patients.

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Section: Epigenetic Alterations In Parkinson’s Diseasementioning

confidence: 99%

Nuclear and Mitochondrial Genome, Epigenome and Gut Microbiome: Emerging Molecular Biomarkers for Parkinson’s Disease

Cabral

Schaan

Cavalcante

et al. 2021

IJMS

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show abstract

“…Parkinson's Disease (PD) ranks second among the most frequent neurodegenerative diseases among the elderly, with a significant increase in its incidence over time 1 . It is characterized by the continuous loss of dopaminergic neurons in the compact part of the substantia nigra of the mesencephalon, resulting in the depletion of dopamine in the nigrostriatal pathway 2 .…”

Section: Introductionmentioning

confidence: 99%

Analysis of the relationship of the vertical extension of mouth opening with muscle rigidity and sociodemographic factors in Parkinson's disease

Silva

Oliveira

Faccio

et al. 2021

Rev. odontol. UNESP

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Introduction Changes caused by the rigidity of Parkinson’s Disease (PD) can affect the mandibular musculature. However, few studies have been published about its impact on the oral opening. Objective To analyze the relationship of the vertical extension of the oral opening with muscular rigidity and sociodemographic factors of the elderly with PD. Material and method This is a cross-sectional, quantitative study that collected data from a primary study conducted at the Hospital das Clínicas of the Federal University of Pernambuco in 2018. Data were collected from medical records and from the questionnaire, Research Diagnostic Criterion for Temporomandibular Disorders (RDC/TMD). The sample was composed of 81 parkinsonians and characterized using: sociodemographic variables and the presence or absence of muscular rigidity. The measures of vertical extension of the oral opening evaluated were: mouth opening without assistance and without pain (ABASD), and maximum mouth opening without assistance (AMBSA). The Pearson’s linear correlation and Spearman’s correlation tests were applied to investigate the relationship among the continuous variables. Analyses of association were conducted using simple logistic regression. The level of significance was set at p<0.05. Result Limitation of the oral opening was not related to age or sex. The greatest level of significance was between mouth opening without assistance and without pain and muscular rigidity (p=0.012), and years of schooling (p=0.038). Conclusion The limitation of mouth opening in people with PD was shown to be related to muscular rigidity and fewer years of schooling.

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Exploring Caenorhabditis elegans as Parkinson’s Disease Model: Neurotoxins and Genetic Implications

da Silva,

da Cruz Guedes,

Fernandes

et al. 2024

Neurotox Res

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Parkinson's disease and atypical parkinsonism: the importance of magnetic resonance imaging as a potential biomarker

Cited by 3 publications

References 12 publications

Nuclear and Mitochondrial Genome, Epigenome and Gut Microbiome: Emerging Molecular Biomarkers for Parkinson’s Disease

Nuclear and Mitochondrial Genome, Epigenome and Gut Microbiome: Emerging Molecular Biomarkers for Parkinson’s Disease

Analysis of the relationship of the vertical extension of mouth opening with muscle rigidity and sociodemographic factors in Parkinson's disease

Exploring Caenorhabditis elegans as Parkinson’s Disease Model: Neurotoxins and Genetic Implications

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