Parkinson's Disease

Jellinger, K. A.

doi:10.1002/9781444341256.ch21

Cited by 21 publications

(25 citation statements)

References 249 publications

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“…Post-mortem investigations in PDD have demonstrated cortical Lewy body (LB) pathology, degenerative changes in critical cortico-subcortical circuits and coexistent Alzheimer's disease (AD) pathology [37]. Concomitant AD pathology (i.e., neuritic plaques and neurofibrillary tangles) is present in over 50% of PDD subjects on post-mortem examination [38].…”

Section: Discussionmentioning

confidence: 99%

Mapping Cortical Atrophy in Parkinson's Disease Patients with Dementia

Hwang

Beyer

Green

et al. 2013

Journal of Parkinson's Disease

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Background: Cognitive impairment is very common in patients with Parkinson's disease (PD). Brain changes accompanying cognitive decline in PD are still not fully established. Methods: We applied cortical pattern matching and cortical thickness analyses to the three-dimensional T1-weighted brain MRI scans of 14 age-matched cognitively normal elderly (NC), 12 cognitively normal PD (PDC), and 11 PD dementia (PDD) subjects. We used linear regression models to investigate the effect of diagnosis on cortical thickness. All maps were adjusted for multiple comparisons using permutation testing with a threshold p < 0.01. Results: PDD showed significantly thinner bilateral sensorimotor, perisylvian, lateral parietal, as well as right posterior cingulate, parieto-occipital, inferior temporal and lateral frontal cortices relative to NC (left p corrected = 0.06, right p corrected = 0.009). PDD showed significantly thinner bilateral sensorimotor, right frontal and right parietal-occipital cortices relative to PDC (right p corrected = 0.05). The absolute difference in cortical thickness between PDD and the other diagnostic groups ranged from 3% to 19%. Conclusion:Our data shows that cognitive decline in PD is associated with cortical atrophy. PDD subjects have the most widespread gray matter atrophy suggesting more cortical involvement as PD patients progress to dementia.

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Section: Discussionmentioning

confidence: 99%

Mapping Cortical Atrophy in Parkinson's Disease Patients with Dementia

Hwang

Beyer

Green

et al. 2013

Journal of Parkinson's Disease

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“…The AD‐related cortical cytoskeletal pathology was classified on these tau‐immunostained sections based on the Braak staging system [36], while brain β‐amyloidosis was assessed according to a recently proposed staging procedure [37]. In addition, in the SCA6 patients select cerebral and brainstem tissue sections were immunostained with an affinity‐purified alpha‐synuclein antiserum (Afshp, gift of Dr Wei Ping Gai, Flinders Medical Centre, Bedford Park, SA, Australia; 1:2000) [38] to visualize neuronal and/or glial inclusions related to Parkinson's disease or other known human synucleinopathies [27,39–41].…”

Section: Methodsmentioning

confidence: 99%

Spinocerebellar ataxia type 6 (SCA6): neurodegeneration goes beyond the known brain predilection sites

Gierga

Schelhaas

Brunt³

et al. 2009

Neuropathology Appl Neurobio

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“…The A10 group of DAergic neurons—the ventral tegmental area, nucleus parabrachialis, and nucleus parabrachialis pigmentosus—projecting to the striatal matrix, thalamus, cortical and limbic areas (mesocorticolimbic system) shows less severe involvement (40%–50% cell loss) 69. The periretrorubral A8 region, which contains only a few DAergic but CAB‐rich neurons, and central periventricular gray matter show little or no degeneration 3, 97…”

Section: Challenges Of Classical Concepts Of Neuropathologymentioning

confidence: 99%

Hedgehog regulates angiogenesis of intersegmental vessels through the VEGF signaling pathway

Moran

Myers

Lewis

et al. 2012

Developmental Dynamics

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The cellular mechanisms regulating branching and growth of the intersegmental vessels (ISVs) are not well understood. We have carried out studies demonstrating that Hedgehog (Hh) signaling is a major regulator of intersomitic vessel growth. Inhibition of Hh activity by cyclopamine completely blocks formation of intersomitic vessels in the avian embryo. Examination of gene expression patterns in Hh deficient embryos shows that components of the VEGF and Notch signaling pathways are down-regulated. However, we find no evidence that Notch signaling plays a significant role in regulation of intersomitic vessel growth. Indeed it appears that Hh modulation of Vascular Endothelial Growth Factor, VEGF, is the primary regulator of growth of intersomitic vessels in the avian embryo. Inhibition of the VEGF pathway results in absence of ISVs, whereas stimulation of VEGF expression leads to precocious branching of ISVs. These results demonstrate that Hh is an essential modulator of VEGF expression during developmental angiogenesis.

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Parkinson's Disease

Cited by 21 publications

References 249 publications

Mapping Cortical Atrophy in Parkinson's Disease Patients with Dementia

Mapping Cortical Atrophy in Parkinson's Disease Patients with Dementia

Spinocerebellar ataxia type 6 (SCA6): neurodegeneration goes beyond the known brain predilection sites

Hedgehog regulates angiogenesis of intersegmental vessels through the VEGF signaling pathway

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