2015
DOI: 10.1017/cjn.2015.328
|View full text |Cite
|
Sign up to set email alerts
|

Parkinson Disease: The Relationship Between Non-motor Symptoms and Motor Phenotype

Abstract: Background: Parkinson disease (PD) presents with motor and non-motor symptoms (NMS). The NMS often precede the onset of motor symptoms, but may progress throughout the disease course. Tremor dominant, postural instability gait difficulty (PIGD), and indeterminate phenotypes can be distinguished using Unified PD Rating scales (UPDRS-III). We hypothesized that the PIGD phenotype would be more likely to develop NMS, and that the non-dopamine-responsive axial signs would correlate with NMS severity. Methods: We co… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

5
26
0

Year Published

2016
2016
2021
2021

Publication Types

Select...
10

Relationship

0
10

Authors

Journals

citations
Cited by 50 publications
(34 citation statements)
references
References 35 publications
5
26
0
Order By: Relevance
“…Furthermore, some of the non‐motor markers seen in the prodromal phase may also appear later in the neurodegenerative phase or become evident even after PD diagnosis. It is known that these markers are generally associated with disease severity in PD . Therefore, not all PD patients might show a broad range of symptoms within the early disease phase, which might at least partly explain the low mean post‐test probability of our PD group (69%).…”
Section: Discussionmentioning
confidence: 90%
“…Furthermore, some of the non‐motor markers seen in the prodromal phase may also appear later in the neurodegenerative phase or become evident even after PD diagnosis. It is known that these markers are generally associated with disease severity in PD . Therefore, not all PD patients might show a broad range of symptoms within the early disease phase, which might at least partly explain the low mean post‐test probability of our PD group (69%).…”
Section: Discussionmentioning
confidence: 90%
“…For each patient we recorded details of demographic data, age at onset, disease duration, symptoms at onset, medications, motor fluctuations and family history. The patients were assessed using United Parkinson Disease Rating Scalemotor section (UPDRS part III) [9]. This scale is an instrument with 27 items which assessed motor function related to tremor, rigidity, posture and bodily movement.…”
Section: Experimental Part Methods and Materialsmentioning
confidence: 99%
“…PIGD is typically defined by a ratio of tremor and gait subscores in UPDRS. Its presence has been associated in many studies with rapid progression of disease, as measured by UPDRS change, cognitive dysfunction and association with other non-motor features [55][56][57][58][59]. However, there are several problems associated with using PIGD as a measure.…”
Section: Associations Neurotransmitters and Pathogenesismentioning
confidence: 99%