Parkinson disease: Electrophysiological (CNV) analysis related to pharmacological treatment

Amabile, G; Fattapposta, Francesco; Pozzessere, G.; Albani, G; Sanarelli, L; Rizzo, P. A.; Morocutti, C

doi:10.1016/0013-4694(86)90189-6

Cited by 55 publications

(35 citation statements)

References 9 publications

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“…The CNV amplitude is decreased in PD patients (Amabile et al, 1986;Praamstra et al, 1996;Ikeda et al, 1997). These findings are consistent with involvement of BG in the preparation of an externally triggered movement.…”

Section: Involvement Of the Stn In The Preparation Of Externally Trigsupporting

confidence: 84%

“…CNV amplitude (Amabile et al, 1986;Pulvermuller et al, 1996;Ikeda et al, 1997) is decreased in PD. Both BP and CNV amplitude have been reported to improve with dopaminergic medications (Amabile et al, 1986;Dick et al, 1987;Jahanshahi et al, 1995;Oishi et al, 1995). However, the CNV is more clearly affected in PD than the BP Berardelli et al, 2001).…”

Section: Implications For Pdmentioning

confidence: 92%

“…This may be because our PD patients were studied in the "on" medication state, whereas in the study by Kuhn et al (2004), the results from patients in the on and "off" medications states were combined. It is known that CNV amplitude increases with dopaminergic medications in PD patients (Amabile et al, 1986;Jahanshahi et al, 1995;Oishi et al, 1995). In addition, the polar- Right-hand movement was performed in all patients.…”

Section: Involvement Of the Stn In The Preparation Of Externally Trigmentioning

confidence: 99%

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Involvement of the Basal Ganglia and Cerebellar Motor Pathways in the Preparation of Self-Initiated and Externally Triggered Movements in Humans

Purzner

Paradiso²,

Cunic³

et al. 2007

J. Neurosci.

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The subthalamic nucleus (STN) is part of the cortico-basal ganglia (BG)-thalamocortical circuit, whereas the ventral lateral nucleus of the thalamus (VL) is a relay nucleus in the cerebello-dentato-thalamocortical (CTC) pathway. Both pathways have been implicated in movement preparation. We compared the involvement of the STN and VL in movement preparation in humans by recording local field potentials (LFPs) from seven patients with Parkinson's disease with deep-brain stimulation (DBS) electrodes in the STN and five patients with tremor and electrodes in VL. LFPs were recorded from DBS electrodes and scalp electrodes simultaneously while the patients performed self-paced and externally cued (ready, go/no-go) movements. For the self-paced movement, a premovement-related potential was observed in all patients from scalp, STN (phase reversal, five of six patients), and VL (phase reversal, five of five patients) electrodes. The onset times of the potentials were similar in the cortex, STN, and VL, ranging from 1.5 to 2 s before electromyogram onset. For the externally cued movement, an expectancy potential was observed in all patients in cortical and STN electrodes (phase reversal, six of six patients). The expectancy potential was recorded from the thalamic electrodes in four of five patients. However, phase reversal occurred only in one case, and magnetic resonance imaging showed that this contact was outside the VL. The cortico-BG-thalamocortical circuit is involved in the preparation of both self-paced and externally cued movements. The CTC pathway is involved in the preparation of self-paced but not externally cued movements, although the pathway may still be involved in the execution of these movements.

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Section: Involvement Of the Stn In The Preparation Of Externally Trigsupporting

confidence: 84%

Section: Implications For Pdmentioning

confidence: 92%

Section: Involvement Of the Stn In The Preparation Of Externally Trigmentioning

confidence: 99%

See 1 more Smart Citation

Involvement of the Basal Ganglia and Cerebellar Motor Pathways in the Preparation of Self-Initiated and Externally Triggered Movements in Humans

Purzner

Paradiso²,

Cunic³

et al. 2007

J. Neurosci.

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“…This distribution supports earlier hypotheses about a reduction of the CNV amplitude in Parkinson's disease patients. Amabile et al (1986) and Wright et al (1993) found such a reduction, which they attributed to an impaired activation of the SMA. This view is supported by an effect of L-dopa on the CNV amplitude (Amabile et al, 1986) and on the restitution of SMA activity indicated by regional cerebral blood flow measured with PET after dopaminergic medication (Jenkins et al, 1992;Rascol et al, 1994).…”

Section: Movement-related Potentials and Externally Cued Versus Intermentioning

confidence: 92%

“…Amabile et al (1986) and Wright et al (1993) found such a reduction, which they attributed to an impaired activation of the SMA. This view is supported by an effect of L-dopa on the CNV amplitude (Amabile et al, 1986) and on the restitution of SMA activity indicated by regional cerebral blood flow measured with PET after dopaminergic medication (Jenkins et al, 1992;Rascol et al, 1994). Further evidence for an SMA contribution to the CNV comes from magnetoencephalographic studies (Ioannides et al, 1994) and a combined magnetoencephalographic and PET study (Stephan et al, 1995ft).…”

Section: Movement-related Potentials and Externally Cued Versus Intermentioning

confidence: 92%

Movement preparation in Parkinson's disease Time course and distribution of movement-related potentials in a movement precueing task

Praamstra¹,

Meyer²,

Cools³

et al. 1996

Brain

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Levels of error processing in Huntington's disease: A combined study using event‐related potentials and voxel‐based morphometry

Beste¹,

Saft²,

Konrad³

et al. 2007

Human Brain Mapping

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Huntington's Disease (HD) is a neurogenetic disorder accompanied by an atrophy of the striatum and hence of the dopaminergic (DA) system. Neural processes subserving error processing presumably depend on the DA system. We assessed error processing in manifest HD and in presymptomatic HD-gene-mutation-carriers (pHD) with event-related potentials reflecting error processing (the error negativity or error-related negativity and the error positivity derived from a flanker-task. We found a reduction of the Ne in the case of HD compared to pHD reflecting dopamine system pathology. Despite the Ne being reduced in HD, behavioral adaptation was possible. In addition, the error-rates did not differ between the groups. Optimized voxel-based morphometry revealed that grey matter volume in the medial frontal gyrus is correlated with the Ne amplitude in symptomatic patients. In addition, the effect of a Ne-reduction was related to the grey matter underneath the medial frontal gyrus, which is in line with two theories of the Ne. In contrast, the Pe did not differ between the groups, suggesting that the Pe is decoupled from the DA system. Interestingly we found a reduction of a late slow negativity on correct responses, which possibly reflects decreased preparatory processes in HD compared to pHD as induced by the DA alterations in HD. In conclusion a deterioration in error processing in HD compared to pHD is mainly reflected by the Ne. The deterioration might rely on two factors: a neurofunctional and a neuroanatomical.

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Parkinson disease: Electrophysiological (CNV) analysis related to pharmacological treatment

Cited by 55 publications

References 9 publications

Involvement of the Basal Ganglia and Cerebellar Motor Pathways in the Preparation of Self-Initiated and Externally Triggered Movements in Humans

Involvement of the Basal Ganglia and Cerebellar Motor Pathways in the Preparation of Self-Initiated and Externally Triggered Movements in Humans

Movement preparation in Parkinson's disease Time course and distribution of movement-related potentials in a movement precueing task

Levels of error processing in Huntington's disease: A combined study using event‐related potentials and voxel‐based morphometry

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