Parkinson disease, edible solanaceae, and tobacco mosaic virus

Liu, Ruolan; Vaishnav, Radhika A.; Roberts, Andrew M.; Friedland, Robert P.

doi:10.1002/ana.24041

Cited by 3 publications

(4 citation statements)

References 6 publications

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“…Many studies have shown that exposure to tobacco products as well as to solanaceous plants in the diet are protective against the development of PD [5,6]. Although there are many theories to explain these effects the mechanisms are unclear.…”

Section: Tobacco Mosaic Virus (Tmv) and Pdmentioning

confidence: 99%

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Mechanisms of Molecular Mimicry Involving the Microbiota in Neurodegeneration

Friedland

2015

JAD

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273

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The concept of molecular mimicry was established to explain commonalities of structure which developed in response to evolutionary pressures. Most examples of molecular mimicry in medicine have involved homologies of primary protein structure which cause disease. Molecular mimicry can be expanded beyond amino acid sequence to include microRNA and proteomic effects which are either pathogenic or salutogenic (beneficial) in regard to Parkinson's disease, Alzheimer's disease, and related disorders. Viruses of animal or plant origin may mimic nucleotide sequences of microRNAs and influence protein expression. Both Parkinson's and Alzheimer's diseases involve the formation of transmissible self-propagating prion-like proteins. However, the initiating factors responsible for creation of these misfolded nucleating factors are unknown. Amyloid patterns of protein folding are highly conserved through evolution and are widely distributed in the world. Similarities of tertiary protein structure may be involved in the creation of these prion-like agents through molecular mimicry. Cross-seeding of amyloid misfolding, altered proteostasis, and oxidative stress may be induced by amyloid proteins residing in bacteria in our microbiota in the gut and in the diet. Pathways of molecular mimicry induced processes induced by bacterial amyloid in neurodegeneration may involve TLR 2/1, CD14, and NFκB, among others. Furthermore, priming of the innate immune system by the microbiota may enhance the inflammatory response to cerebral amyloids (such as amyloid-β and α-synuclein). This paper describes the specific molecular pathways of these cross-seeding and neuroinflammatory processes. Evolutionary conservation of proteins provides the opportunity for conserved sequences and structures to influence neurological disease through molecular mimicry.

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Section: Tobacco Mosaic Virus (Tmv) and Pdmentioning

confidence: 99%

“…The foreign antigen eliciting MM has most often been reported to be present in bacteria or animal viruses. The concept of MM can be expanded to include the ability of foreign proteins from plant viruses to induce autoimmunity [4][5][6]. Plant proteins in food may also elicit MM and cause demyelination [7].…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of Molecular Mimicry Involving the Microbiota in Neurodegeneration

Friedland

2015

JAD

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273

182

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“…Another plant RNA virus, tobacco mosaic virus (TMV), was also reported to affect human health, and individuals who smoked showed high levels of antibodies against TMV proteins [17]. It has also been proposed that high levels of TMV antibodies might be associated with a lower risk of developing Parkinson's disease [17,18,20]. These examples suggest that some plant RNA viruses may affect human health.…”

Section: Introductionmentioning

confidence: 99%

Plant RNA Virus Sequences Identified in Kimchi by Microbial Metatranscriptome Analysis

Kim¹,

Jung²,

Wang³

et al. 2014

Journal of Microbiology and Biotechnology

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Plant pathogenic RNA viruses are present in a variety of plant-based foods. When ingested by humans, these viruses can survive the passage through the digestive tract, and are frequently detected in human feces. Kimchi is a traditional fermented Korean food made from cabbage or vegetables, with a variety of other plant-based ingredients, including ground red pepper and garlic paste. We analyzed microbial metatranscriptome data from kimchi at five fermentation stages to identify plant RNA virus-derived sequences. We successfully identified a substantial amount of plant RNA virus sequences, especially during the early stages of fermentation: 23.47% and 16.45% of total clean reads on days 7 and 13, respectively. The most abundant plant RNA virus sequences were from pepper mild mottle virus, a major pathogen of red peppers; this constituted 95% of the total RNA virus sequences identified throughout the fermentation period. We observed distinct sequencing read-depth distributions for plant RNA virus genomes, possibly implying intrinsic and/or technical biases during the metatranscriptome generation procedure. We also identified RNA virus sequences in publicly available microbial metatranscriptome data sets. We propose that metatranscriptome data may serve as a valuable resource for RNA virus detection, and a systematic screening of the ingredients may help prevent the use of virus-infected low-quality materials for food production.

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“…As a result, the cross-reactivity between anti-TMV antibodies and TOMM40L was observed. Since alterations in the TOM complex (made up of TOMM22, TOMM40, TOMM40L and TOMM70) have been linked with AD and PD pathogenesis, TMV has great potential as a therapeutic tool for those NDDs [ 160 , 161 ]. Indeed, TMV might be utilized as a multifunctional agent that can initiate immune responses against AD and PD both through the selected antigen carried by the said vector and through its associated viral particles [ 162 , 163 ].…”

Section: Future Directionsmentioning

confidence: 99%

Current Advances of Plant-Based Vaccines for Neurodegenerative Diseases

et al. 2023

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Neurodegenerative diseases (NDDs) are characterized by the progressive degeneration and/or loss of neurons belonging to the central nervous system, and represent one of the major global health issues. Therefore, a number of immunotherapeutic approaches targeting the non-functional or toxic proteins that induce neurodegeneration in NDDs have been designed in the last decades. In this context, due to unprecedented advances in genetic engineering techniques and molecular farming technology, pioneering plant-based immunogenic antigen expression systems have been developed aiming to offer reliable alternatives to deal with important NDDs, including Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. Diverse reports have evidenced that plant-made vaccines trigger significant immune responses in model animals, supported by the production of antibodies against the aberrant proteins expressed in the aforementioned NDDs. Moreover, these immunogenic tools have various advantages that make them a viable alternative for preventing and treating NDDs, such as high scalability, no risk of contamination with human pathogens, cold chain free production, and lower production costs. Hence, this article presents an overview of the current progress on plant-manufactured vaccines for NDDs and discusses its future prospects.

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Parkinson disease, edible solanaceae, and tobacco mosaic virus

Abstract: Puetz V, Sylaja PN, Coutts SB, et al. Extent of hypoattenuation onCT angiography source images predicts functional outcome in patients with basilar artery occlusion.

Cited by 3 publications

References 6 publications

Mechanisms of Molecular Mimicry Involving the Microbiota in Neurodegeneration

Mechanisms of Molecular Mimicry Involving the Microbiota in Neurodegeneration

Plant RNA Virus Sequences Identified in Kimchi by Microbial Metatranscriptome Analysis

Current Advances of Plant-Based Vaccines for Neurodegenerative Diseases

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