Parkin-mediated responses against infection and wound involve TSPO-VDAC complex in Drosophila

Cho, Jaeho; Park, Jeong Hyang; Chung, Chang Geon; Shim, Hyun-Jung; Jeon, Keun Hye; Yu, Seong‐Woon; Lee, Sung Bae

doi:10.1016/j.bbrc.2015.05.006

Cited by 13 publications

(7 citation statements)

References 34 publications

(30 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PPIX, PK 11195, and Ro5-4864 were all found to enhance mitochondrial processing of the hMn-SOD precursor protein, suggesting a role for the TSPO in the regulation of mitochondrial transport of proteins, as well as life span extension [ 82 ]. It was also found in Drosophila that TSPO serves to counteract infection and promote wound healing [ 83 ]. In addition, PPIX can reduce genetic damage in Drosophila [ 81 ].…”

Section: Tetrapyrroles Including Protoporphyrins Such As Ppix Asmentioning

confidence: 99%

Tetrapyrroles as Endogenous TSPO Ligands in Eukaryotes and Prokaryotes: Comparisons with Synthetic Ligands

Veenman

Vainshtein

Yasin

et al. 2016

IJMS

View full text Add to dashboard Cite

The 18 kDa translocator protein (TSPO) is highly 0conserved in eukaryotes and prokaryotes. Since its discovery in 1977, numerous studies established the TSPO’s importance for life essential functions. For these studies, synthetic TSPO ligands typically are applied. Tetrapyrroles present endogenous ligands for the TSPO. Tetrapyrroles are also evolutionarily conserved and regulate multiple functions. TSPO and tetrapyrroles regulate each other. In animals TSPO-tetrapyrrole interactions range from effects on embryonic development to metabolism, programmed cell death, response to stress, injury and disease, and even to life span extension. In animals TSPOs are primarily located in mitochondria. In plants TSPOs are also present in plastids, the nuclear fraction, the endoplasmic reticulum, and Golgi stacks. This may contribute to translocation of tetrapyrrole intermediates across organelles’ membranes. As in animals, plant TSPO binds heme and protoporphyrin IX. TSPO-tetrapyrrole interactions in plants appear to relate to development as well as stress conditions, including salt tolerance, abscisic acid-induced stress, reactive oxygen species homeostasis, and finally cell death regulation. In bacteria, TSPO is important for switching from aerobic to anaerobic metabolism, including the regulation of photosynthesis. As in mitochondria, in bacteria TSPO is located in the outer membrane. TSPO-tetrapyrrole interactions may be part of the establishment of the bacterial-eukaryote relationships, i.e., mitochondrial-eukaryote and plastid-plant endosymbiotic relationships.

show abstract

Section: Tetrapyrroles Including Protoporphyrins Such As Ppix Asmentioning

confidence: 99%

Tetrapyrroles as Endogenous TSPO Ligands in Eukaryotes and Prokaryotes: Comparisons with Synthetic Ligands

Veenman

Vainshtein

Yasin

et al. 2016

IJMS

View full text Add to dashboard Cite

show abstract

“…5 E ). Inflammation has been shown to induce Gnmt expression in fat body ( 37 ), and Tspo knockdown results in defective responses to infection ( 38 ). It is intriguing that Gnmt and Tspo have opposing effects on longevity in flies: overexpression of Gnmt extends lifespan ( 39 ), whereas inhibition of Tspo prolongs lifespan and protects against neurodegeneration ( 40 ).…”

Section: Resultsmentioning

confidence: 99%

Quantitative Proteomic and Metabolomic Profiling Reveals Altered Mitochondrial Metabolism and Folate Biosynthesis Pathways in the Aging Drosophila Eye

Hall

Cooper

et al. 2021

Molecular & Cellular Proteomics

View full text Add to dashboard Cite

Aging is associated with increased risk of ocular disease, suggesting that age-associated molecular changes in the eye increase its vulnerability to damage. Although there are common pathways involved in aging at an organismal level, different tissues and cell types exhibit specific changes in gene expression with advanced age. Drosophila melanogaster is an established model system for studying aging and neurodegenerative disease that also provides a valuable model for studying age-associated ocular disease. Flies, like humans, exhibit decreased visual function and increased risk of retinal degeneration with age. Here, we profiled the aging proteome and metabolome of the Drosophila eye and compared these data with age-associated transcriptomic changes from both eyes and photoreceptors to identify alterations in pathways that could lead to age-related phenotypes in the eye. Of note, the proteomic and metabolomic changes observed in the aging eye are distinct from those observed in the head or whole fly, suggesting that tissue-specific changes in protein abundance and metabolism occur in the aging fly. Our integration of the proteomic, metabolomic, and transcriptomic data reveals that changes in metabolism, potentially due to decreases in availability of B vitamins, together with chronic activation of the immune response, may underpin many of the events observed in the aging Drosophila eye. We propose that targeting these pathways in the genetically tractable Drosophila system may help to identify potential neuroprotective approaches for neurodegenerative and age-related ocular diseases. Data are available via ProteomeXchange with identifier PXD027090.

show abstract

“…The additional susceptibility factors are divided into genetic and environmental factors. On the one hand, some of the (suspected or confirmed) genetic risk factors for PD, MSA, or DLB 71,[160][161][162][163][164] seem to be related to the host's susceptibility to infections, including the LRRK2 gene, [165][166][167][168][169][170][171] the PRKN gene, [172][173][174][175][176][177] the VPS35 gene, 178 the GBA gene, 179 the E4 allele of the APOE gene 180 and finally the CTSB gene. 181 Similar associations were also found for the COQ2, EDN1, SHC2, and MAPT genes, but with P values not reaching the threshold usually used in genome-wide association study (GWAS).…”

Section: Are Certain Susceptibility Factors Necessary For An Infectio...mentioning

confidence: 99%

Infectious Agents as Potential Drivers of α‐Synucleinopathies

Linard

Ravier

Mougué³

et al. 2022

Movement Disorders

View full text Add to dashboard Cite

α‐synucleinopathies, encompassing Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy, are devastating neurodegenerative diseases for which available therapeutic options are scarce, mostly because of our limited understanding of their pathophysiology. Although these pathologies are attributed to an intracellular accumulation of the α‐synuclein protein in the nervous system with subsequent neuronal loss, the trigger(s) of this accumulation is/are not clearly identified. Among the existing hypotheses, interest in the hypothesis advocating the involvement of infectious agents in the onset of these diseases is renewed. In this article, we aimed to review the ongoing relevant factors favoring and opposing this hypothesis, focusing on (1) the potential antimicrobial role of α‐synuclein, (2) potential entry points of pathogens in regard to early symptoms of diverse α‐synucleinopathies, (3) pre‐existing literature reviews assessing potential associations between infectious agents and Parkinson's disease, (4) original studies assessing these associations for dementia with Lewy bodies and multiple system atrophy (identified through a systematic literature review), and finally (5) potential susceptibility factors modulating the effects of infectious agents on the nervous system. © 2022 International Parkinson and Movement Disorder Society

show abstract

Parkin-mediated responses against infection and wound involve TSPO-VDAC complex in Drosophila

Cited by 13 publications

References 34 publications

Tetrapyrroles as Endogenous TSPO Ligands in Eukaryotes and Prokaryotes: Comparisons with Synthetic Ligands

Tetrapyrroles as Endogenous TSPO Ligands in Eukaryotes and Prokaryotes: Comparisons with Synthetic Ligands

Quantitative Proteomic and Metabolomic Profiling Reveals Altered Mitochondrial Metabolism and Folate Biosynthesis Pathways in the Aging Drosophila Eye

Infectious Agents as Potential Drivers of α‐Synucleinopathies

Contact Info

Product

Resources

About