Abstract:Macrophages are involved mainly in the balance between inflammation and tenogenesis during the healing process of tendinopathy. However, there is still lack of etiological therapeutic strategies to modulate macrophage state to treat tendinopathy efficiently. Here, we find that a small molecule compound Parishin-A (PA) isolated from Gastrodia elata could promote anti-inflammatory M2 macrophage polarization by inhibiting gene transcription and protein phosphorylation of signal transducers and activators of trans… Show more
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