Parietal cell carcinoma of the stomach

Abstract

Two cases of parietal cell carcinoma are reported and compared with seven cases previously described. Eight of nine patients have been male. The tumours grow mainly outside the mucosa and can macro‐and microscopically be misinterpreted as leiomyoblastomas or lymphomas. The survival, also with metastases, is long. The proper diagnosis requires ultrastructural investigation.

Oncocytic adenocarcinoma of the stomach: Parietal cell carcinoma

“…Cafferty et al, [3] reported positive staining for cytokeratin AE1/AE3, in a case with parietal cell carcinoma of the stomach. [4] The present case confirms typical features of parietal cell (oncocytic) adenocarcinoma described by others, such as extensive submucosal spreading while the lymph node involvement and metastatic deposits in the omentum are unusual findings of this report. They found epithelial markers positive in other epithelial cells of the gastric mucosa, and concluded that the diagnosis should be based on electron microscopic findings.…”

Parietal Cell (Oncocytic) Adenocarcinoma of the Stomach in a Female Patient: Superficial Spreading and Extensive Nodal Involvement

“…There was a striking male predominance (9:1) and the mean age was 70.5 ± 7.9 years, 1 which is in agreement with previous data. 3 Immunohistochemistry revealed positive staining for human gastric mucin and mitochondria and absence of H + -K + -ATPase expression. 1 The authors thus suggested the use of oncocytic carcinoma nomenclature rather than parietal cell carcinoma since H + -K + -ATPase is considered a marker parietal gastric cell differentiation.…”

“…2 The tumor may grow as an intramucosal or a submucosal mass. 1,3 In a recent study, the largest series available W e report a case of parietal cell (oncocytic) adenocarcinoma in a 62-year-old woman. Her past history was unremarkable and she had no previous diagnosis of neoplasia.…”

Characterization by Lectin Histochemistry of Two Subpopulations of Parietal Cells in the Rat Gastric Glands

“…[7][8][9][10] The study of the parietal cell differentiation is interesting both to understand the turnover of the gastric gland epithelium and to better understand the gastric pathological disorders. 10,11 Cell differentiation involves the expression of new proteins or the expression of new oligosaccharides on glycoproteins and other glycosylated molecules (called glycoconjugates). Changes in the glycoconjugates of the gastric mucosa have been reported in precancerous intestinal metaplasia, 12 gastric carcinoma, 13 and infection by Helicobacter pylori.…”