“…uncertainty in the control vari-able runaway boundaries, and the inherent random disturbances of the control variable setpoint. 5,8,9,[32][33][34][35][36] On the other hand, the plant optimal operating policy should be considered as a trade-off between economic, environmental, and safety objectives. By using a new "safe operation criterion" introduced by Maria and Dan,[10][11][12][13][14] based on the sum of two failure probability indices related to uncertainty in the reactor runaway boundaries and random disturbances in the operating parameters, a multi-objective optimization can be formulated by defining the sustainability by simultaneously considering technological, economic, and safety constraints.…”