Parents' knowledge and sources of knowledge about antipyretic drugs

Kapasi, Abbas A; Lorin, Martin I.; Nirken, Milton; Yudovich, Martin

doi:10.1016/s0022-3476(80)80453-7

Cited by 17 publications

(10 citation statements)

References 5 publications

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“…Little published data exists on levels of OTC cough and cold preparations in infants and children; thus, dosing guidelines historically have been extrapolated from adult data, making them imprecise for children. 6 In 2 studies, caregivers reported that they primarily followed dosing guidelines on the medication package 28,29 ; however, this too allows for many potential errors. They can misunderstand the recommended dose, frequency or length of therapy, use an incorrect measuring device, or even give the wrong preparation.…”

Section: Discussionmentioning

confidence: 99%

“…When appropriate doses of pediatric formulations don't achieve the desired outcome, parents may increase the dose, or give adult preparations that may be perceived as stronger. 32 Kapasi et al 28 noted in a study of acetaminophen use, that a significant percentage of poisonings from acetaminophen were secondary to excessive dosing, rather than unintentional ingestion. In the third case report, the child tragically died from an overdose of cough and cold medications that likely had been persistently administered because of continued symptoms in the child.…”

Section: Discussionmentioning

confidence: 99%

“…5,33 Additionally, many parents may simply be unaware of the potentially serious side effects of OTC cough and cold medications. 28 Despite the risks of OTC cough and cold medicines, many parents believe they should treat their children's cold symptoms with medication. 4 Cold remedies are a formidable industry; in 1990 alone, nearly $2 billion was spent on OTC cough and cold preparations nationwide.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Toxicity of Over-the-Counter Cough and Cold Medications

Gunn¹,

Taha²,

Liebelt³

et al. 2001

Pediatrics

133

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ABSTRACT. Over-the-counter (OTC) cough and cold medications are marketed widely for relief of common cold symptoms, and yet studies have failed to demonstrate a benefit of these medications for young children. In addition, OTC medications can be associated with significant morbidity and even mortality in both acute overdoses and when administered in correct doses for chronic periods of time. Physicians often do not inquire about OTC medication use, and parents (or other caregivers) often do not perceive OTCs as medications. We present 3 cases of adverse outcomes over a 13-month period-including 1 death-as a result of OTC cough and cold medication use. We explore the toxicities of OTC cough and cold medications, discuss mechanisms of dosing errors, and suggest why physicians should be more vigilant in specifically inquiring about OTCs when evaluating an ill child. Pediatrics 2001;108(3). URL: http://www.pediatrics.org/cgi/content/full/108/3/e52; over-the-counter medications, cough and cold preparations, morbidity, mortality, phenylpropanolamine.ABBREVIATIONS. OTC, over-the-counter; PPA, phenylpropanolamine; ED, emergency department; PICU, pediatric intensive care unit; CBC, complete blood (cell) count; WBC, white blood cell (count); bpm, beats per minute; AAP, American Academy of Pediatrics; CNS, central nervous system; FDA, Food and Drug Administration. C olds, coughs, and upper respiratory infections are common childhood illnesses. The average child suffers from 6 to 10 colds per year, and each cold can last from 10 to 14 days, providing several days and nights of discomfort for the child as well as for his/her caregiver. 1 Many times parents will turn to one of many hundreds of cough and cold preparations for relief. However, over-the-counter (OTC) cough and cold preparations-although generally safe-have no demonstrated benefit. No studies have proven the efficacy of cough and cold preparations in facilitating recovery from these illnesses, 2-6 and most children will eventually improve on their own. However, a small number of children may suffer significant adverse effects from the administration of the very cough and cold formulations they were given in an attempt to relieve their symptoms. For example, the Food and Drug Administration recently issued an advisory to remove phenylpropanolamine (PPA)-a common constituent of OTC decongestants-from those products because of concern for increased risk of hemorrhagic stroke. 7,8 We present 3 cases of children who suffered significant morbidity from OTC cough and cold preparations requiring admission and treatment in a tertiary care hospital during a 13-month period; they ranged from a self-limited reaction requiring an intensive care unit admission to death in 1 patient. Because no cases of death or heart failure attributable to OTC cough and cold preparations have been reported in recent literature, these cases are presented to serve as points for additional discussion on the risks of OTC cough and cold preparations in children. CASE REPORTS Case 1A 36-month-old b...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Toxicity of Over-the-Counter Cough and Cold Medications

Gunn¹,

Taha²,

Liebelt³

et al. 2001

Pediatrics

133

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“…The minority of our respondents were aware that OTC drugs could be harmful and knowledge about aspirin, the most commonly used OTC drug, was unsatisfactory with only 18% of urban respondents and 15% of rural respondents aware that aspirin in overdose is potentially fatal. In the United States 89% of a sample of parents of varying socio-economic status realized that an overdose of aspirin could be fatal (Kapasi et al, 1980). Failure to alter the dose of OTC drugs for children (5.5% of urban respondents and 10.5% of rural respondents) is potentially dangerous, particularly for drugs like aspirin and chloroquine.…”

Section: Introduction Methodsmentioning

confidence: 99%

Self‐medication in urban and rural Zimbabwean communities.

Stein¹,

Gora²,

Macheka³

1989

Brit J Clinical Pharma

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“…Os analgésicos, antitérmicos e antiinflamatórios não hormonais estão entre os medicamentos mais amplamente utilizados por crianças, com ou sem prescrição médica e, na maioria das vezes, sua utilização é indicada para o tratamento da febre e das dores que acompanham as IRA 3,5,21,25,27,29,[31][32][33]38,42,49 .…”

Section: Medicamentos Utilizados Como Analgésicos Antitérmi-cos E Anunclassified

Controversial drugs in otorhinolaryngology

Bricks¹,

Sih²

1999

J Pediatr (Rio J)

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Doutor em Medicina pela FMUSP. Médica Assistente do Instituto daCriança -HCFMUSP. Doutor em Medicina pela FMUSP. Docente Responsável pela OtologiaOcupacional da FMUSP -Lab. de Investigações Médicas (LIM) 40. AbstractObjectives: To present a review on the most important groups of drugs used to treat otorhinolaryngological disorders.Method: Review of the literature about treatment of pediatric upper respiratory infections and allergy, using MEDLINE and LILACS data.Results and comments: Pediatric otorhinolaryngological disorders are extremely frequent and most of the time acute. They are one of the major reasons for pediatric visits. The therapeutical management of these conditions in many cases accounts for an over use of drugs, specially antibiotics, antipyretic and drugs of doubtful value, such as decongestants and expectorants. Judicious use, correct indication, and side effects of these drugs must be better known by physicians who deal with the child's health. 1999; 75(1): 11-22: respiratory infections, allergy, drugs. J. pediatr. (Rio J.). ResumoObjetivo: Apresentar uma revisão sobre os medicamentos mais utilizados no tratamento das afecções otorrinolaringológicas.Métodos: Revisão da literatura sobre a terapêutica das infecções respiratórias agudas de vias aéreas superiores e rinite alérgica na criança, utilizando os dados do MEDLINE e LILACS.Resultados e Comentários: As afecções otorrinolaringológi-cas na infância são freqüentes e, na maioria das vezes, agudas. São uma das principais queixas em consultas pediátricas. Na abordagem terapêutica dessas afecções, em inúmeras circunstâncias, observase um uso excessivo de remédios, especialmente antibióticos, antitérmicos/antiinflamatórios e fármacos de ação questionável, como descongestionantes e mucolíticos. O uso judicioso, a correta indicação e os efeitos colaterais desses fármacos devem ser do conhecimento dos médicos que abordam a saúde da criança. J. pediatr. (Rio J.). 1999; 75(1):11-22:infecções respiratórias, alergia, fármacos, criança. IntroduçãoAs afecções otorrinolaringológicas são extremamente comuns na criança, especialmente, as infecções respirató-rias agudas (IRA) que, geralmente, são febris 1-13 , e a rinite alérgica [14][15][16][17] . Em muitos países, observa-se um uso excessivo de medicamentos considerados desnecessários e prejudiciais às crianças para o tratamento dessas patologias, além do abuso de antibióticos, visto que a maioria das IRA é de etiologia viral e tem cura espontânea 2,3,12,13,18,19 .Estima-se que 2/3 de todas as drogas utilizadas em crianças podem ter pouco ou nenhum valor terapêutico, o que implica em enorme desperdício de recursos. Além disso, a exposição de crianças aos fármacos na época de maior crescimento e desenvolvimento é muito preocupante, pois a criança é mais sensível do que o adulto aos efeitos tóxicos dos medicamentos. Essa questão é ainda mais grave quando são utilizados medicamentos recentemente liberados para o comércio, pois os dados sobre a segurança dos novos medicamentos têm muitas limitações, especialmente...

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Parents' knowledge and sources of knowledge about antipyretic drugs

Cited by 17 publications

References 5 publications

Toxicity of Over-the-Counter Cough and Cold Medications

Toxicity of Over-the-Counter Cough and Cold Medications

Self‐medication in urban and rural Zimbabwean communities.

Controversial drugs in otorhinolaryngology

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