Parents ethanol use impairs ethanol-naive offspring development and reproduction

Abstract

Parental ethanol consumption can influence the offspring phenotype. In this way, we analyzed the impairments of maternal and paternal high ethanol consumption during postpuberty on the physical development, feeding pattern, puberty onset and reproductive function of ethanol-naive offspring to birth to adulthood. Female and male UChB rats (voluntary 10%, v/v ethanol consumer) were divided into a control group (C) and an ethanol exposed group (E) from 65 to 80 days of age. The C and E were mated at 100 days. The maternal parameters and offspring development and reproduction parameters were monitored. We observed reduced feeding intake and body weight in the dams of E group throughout gestation and lactation period. Delay in physical development, lower body weight and altered feeding pattern were observed in female and male offspring of E group. In addition, the puberty onset was delayed in both sexes, with lower testosterone levels in the juvenile and pubertal males. There was a prolongation on the estrous and proestrus phases in females from E but the estrous cycle duration did not change between groups. Ovary and uterus weight were reduced in pubertal and adult females from E group. Reduced epididymis and seminal vesicle weight, increased sperm abnormalities, decrease in the daily sperm production and accelerated epididymal transit time were observed in E males. The high maternal and paternal ethanol use on postpuberty impairs the parameters of ethanol-naive offspring inducing alteration on development and reproduction.

Low and high postpubertal ethanol use: damage on adulthood reproduction and offspring

“…Preconception nutrition, body weight index, gestational weight gain and food cons Robertson 2005 , Rando & Simmons 2015 ) since the seminal fluid stimulates the female reproductive tract to produce growth factors and cytokines which protect the embryo ( Robertson 2005 ), and changes in the seminal signalization can also influence descendants ( Bromfield et al 2014 ). The landmarks of physical development of offspring sired by alcoholic parents were altered in our study, similar to results by Fioravante et al (2021) . The insulin-like growth factor (IGF) is important for fetal and postnatal development, and IGF deficiency implicates signaling pathways and normal body growth ( Kanaka-Gantenbein et al 2003 ).…”

The low and high postpubertal ethanol use: long-term effects on drinkers’ reproductive parameters and ethanol-naive offspring development

“…Associated, the paternal experiences play an additional role (Robertson 2005, Rando & Simmons 2015 since the seminal fluid stimulates the female reproductive tract to produce growth factors and cytokines which protect the embryo (Robertson 2005) and changes in the seminal signalization are capable of influencing descendants (Bromfield et al 2014). The landmarks of physical development on offspring sired by alcoholic use by parents were altered in our study, similar to results by Fioravante et al (2021). The insulin-like growth factor (IGF) is important for fetal and postnatal development and IGF deficiency implicates signaling pathways and normal body growth (Kanaka-Gantenbein et al 2003).…”