Parents’ adulthood stress induces behavioral and hormonal alterations in male rat offspring

Niknazar, Somayeh; Nahavandi, Arezo; Najafi, Rezvan; Danialy, Samira; Mehrjerdi, Fatemeh Zare; Karimi, Mohsen

doi:10.1016/j.bbr.2013.05.026

Cited by 11 publications

(5 citation statements)

References 58 publications

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“…Although FST is mostly used to assess the antidepressant effectiveness of novel drugs, the FST has also been used by a large number of studies to test depressive behaviours in animal models of mood disorders (Amiri et al, 2015;Andre et al, 2014;Brenes et al, 2008;Zheng et al, 2016). In addition, increased serum corticosterone concentration has been consistent with previous studies suggesting that physiological responses to repeated stress are associated with activation of the hypothalamicpituitary-adrenal axis (Niknazar et al, 2013;Niknazar et al, 2016;Ottenweller et al, 1992). Other results of the current study showed decreased expression of hippocampal BDNF and increased methylation of this gene in the stressed groups as compared to control.…”

Section: Discussionsupporting

confidence: 73%

Ginkgo biloba modulates hippocampal BDNF expression in a rat model of chronic restraint stress-induced depression

et al. 2020

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Introduction: Mood disorders such as depression and anxiety disorders have been affecting a relatively high proportion of the world's population. Neuroplasticity hypothesis of depression proposes that lack of brain-derived neurotrophic factor (BDNF) can cause structural changes in the brain. The extract of Ginkgo biloba (Gb) leaves can restore much of the damage in the nervous system. We examined the antidepressant role of Gb extract (EGb 761) on BDNF expression modulation in the hippocampus of rats subjected to repeated restraint stress (RRS). Methods: Adult male rats were randomly divided into 10 groups: control, control-vehicle treated, stress, stress-vehicle treated, as well as three control and three experimental groups pretreated with EGb (15, 30, 60mg/kg, IP daily) for 21 days. They underwent restraint stress on a daily basis, 6 hours for 21 consecutive days. Weight changes, locomotor activity and forced swim test (FST) were employed to assess depressive-like symptoms. The serum corticosterone level was also measured by ELISA. Hippocampal BDNF DNA methylation and protein expression were assayed by methylation sensitive restriction enzymes (Real Time PCR) and Western-blotting respectively in all groups. Results: Pre-treatment with 30 and 60 mg/kg/day of Gb extract significantly attenuated depressive-like effects in the body weight, FST and serum corticosterone level in RSS rats compared to control groups. Further, it inhibited chronic stress-induced alterations in the hippocampal BDNF DNA methylation and protein expression. Conclusion: These findings suggest that Gb can induce an antidepressant role through its modulation effect on the hippocampal BDNF expression.

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Section: Discussionsupporting

confidence: 73%

Ginkgo biloba modulates hippocampal BDNF expression in a rat model of chronic restraint stress-induced depression

et al. 2020

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“…This includes the father’s role in prenatal programming. Recent rodent models have demonstrated adverse effects of paternal pre-conception stress on offspring HPA axis regulation via modified spermatogenesis (Niknazar et al, 2013) and epigenetic alterations of sperm microRNA (Rodgers, Morgan, Bronson, Revello, & Bale, 2013). Additional work has reported changes in DNA methlyation in offspring hippocampus and frontal lobes resulting from paternal pre-conception stress (e.g., Mychasiuk, Harker, Ilnytskyy, & Gibb, 2013)—findings similar to those reported in the maternal prenatal programming literature.…”

Section: Discussionmentioning

confidence: 99%

Intergenerational transmission of self-regulation: A multidisciplinary review and integrative conceptual framework.

Bridgett¹,

Burt²,

Edwards³

et al. 2015

Psychological Bulletin

490

476

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This review examines mechanisms contributing to the intergenerational transmission of self-regulation. To provide an integrated account of how self-regulation is transmitted across generations, we draw from over 75 years of accumulated evidence, spanning case studies to experimental approaches, in literatures covering developmental, social, and clinical psychology, and criminology, physiology, genetics, and human and animal neuroscience (among others). First, we present a taxonomy of what self-regulation is and then examine how it develops – overviews that guide the main foci of the review. Next, studies supporting an association between parent and child self-regulation are reviewed. Subsequently, literature that considers potential social mechanisms of transmission, specifically parenting behavior, inter-parental (i.e., marital) relationship behaviors, and broader rearing influences (e.g., household chaos) are considered. Finally, literature providing evidence that prenatal programming may be the starting point of the intergenerational transmission of self-regulation is covered, along with key findings from the behavioral and molecular genetics literatures. To integrate these literatures, we introduce the Self-Regulation Intergenerational Transmission Model, a framework that brings together prenatal, social, and neurobiological mechanisms (spanning endocrine, neural, and genetic levels, including gene-environment interplay and epigenetic processes) to explain the intergenerational transmission of self-regulation. This model also incorporates potential transactional processes between generations (e.g., children’s self-regulation and parent-child interaction dynamics that may affect parents’ self-regulation) that further influence intergenerational processes. In pointing the way forward, we note key future directions and ways to address limitations in existing work throughout the review and in closing. We also conclude by noting several implications for intervention work.

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“…Eighteen adult male Wistar rats were anesthetized by intraperitoneal injection of xylazine and ketamine . After shaving the dorsal surfaces of rats, one wound (8 mm in diameter) was created on the midline of the rat's neck.…”

Section: Methodsmentioning

confidence: 99%

“…Eighteen adult male Wistar rats were anesthetized by intraperitoneal injection of xylazine and ketamine. 20 After shaving the dorsal surfaces of rats, one wound (8 mm in diameter) was created on the midline of the rat's neck. Rats were randomly divided into three groups, which were treated with 100 μL PBS, 1×10 6 MSCs in 100 μL PBS alone and 1×10 6 ATRA-treated MSCs in 100 μL PBS around the wounds at four injection sites.…”

Section: Wound-healing Modelmentioning

confidence: 99%

All‐trans retinoic acid preconditioning enhances proliferation, angiogenesis and migration of mesenchymal stem cell in vitro and enhances wound repair in vivo

et al. 2016

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Parents’ adulthood stress induces behavioral and hormonal alterations in male rat offspring

Cited by 11 publications

References 58 publications

Ginkgo biloba modulates hippocampal BDNF expression in a rat model of chronic restraint stress-induced depression

Ginkgo biloba modulates hippocampal BDNF expression in a rat model of chronic restraint stress-induced depression

Intergenerational transmission of self-regulation: A multidisciplinary review and integrative conceptual framework.

All‐trans retinoic acid preconditioning enhances proliferation, angiogenesis and migration of mesenchymal stem cell in vitro and enhances wound repair in vivo

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