Parenteral Superoxide Dismutase Plus Catalase Diminishes Pancreatic Edema in Sodium Taurocholate-Induced Pancreatitis in the Rat

Pj, Blind; Sl, Marklund; Stenling, Roger; St, Dahlgren

doi:10.1097/00006676-198810000-00009

Cited by 17 publications

(2 citation statements)

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“…Possibly, other pathomechanisms overwhelm the effect of enhanced radical generation, inducing a fulminant hemorrhagic necrotizing pancreatitis. Accordingly, it was shown in two different experimental models of hemorrhagic pancreatitis (sodium taurocholate and choline-deficient, ethionine-supplemented pancreatitis) that oxygen radicals were only of minor importance in the pathogenesis and development of the acute inflammation (26,27).…”

Section: Discussionmentioning

confidence: 99%

Lipid Peroxidation and Glutathione Metabolism in Chronic Pancreatitis

Büchler

Pietrzyk

et al. 1995

Pancreas

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In experimental models of pancreatitis lipid peroxidation products are increased possibly because of an enhanced generation of oxygen radicals. The purpose of this study was to determine whether lipid peroxidation products are increased in pancreatic tissue and serum of patients suffering from chronic or acute pancreatitis. In 20 patients undergoing operative treatment for chronic ( n = 11) and acute pancreatitis ( n = 9) the levels of malondialdehyde, conjugated dienes, and reduced and oxidized glutathione were determined in resected tissue samples. The excised tissue was examined and evaluated by light microscopy. Shortly before operation the serum concentrations of malondialdehyde, a-amylase, and lipase were measured. Pancreatic tissue from eight organ donors who had no abdominal trauma or pancreatic disease served as control. In chronic pancreatitis, conjugated dienes as well as malondialdehyde concentrations in the tissue were significantly elevated. Reduced glutathione was significantly decreased, suggesting glutathione depletion due to oxidative stress. In acute pancreatitis only the tissue and serum malondialdehyde levels were significantly high, whereas conjugated dienes remained within the normal range. Serum malondialdehyde levels correlated significantly with tissue concentrations (r = 0.76; p < 0.05) but not with the clinical course or the enzyme levels. In chronic pancreatitis, the increased tissue levels of lipid peroxidation products and the changes in glutathione metabolism suggest ongoing peroxidation of lipids due to an enhanced generation of oxygen radicals. In hemorrhagic necrotizing pancreatitis, however, oxygen radical-induced lipid peroxidation cannot be proven. Apparently, other pathomechanisms are involved in the development of the severe tissue damage.

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Section: Discussionmentioning

confidence: 99%

Lipid Peroxidation and Glutathione Metabolism in Chronic Pancreatitis

Büchler

Pietrzyk

et al. 1995

Pancreas

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“…Das Taurocholat-Modell wurde aufgrund seiner leichten Reproduzierbarkeit sowie der Modifizierbarkeit der pankreatitistypischen Veränderungen und seiner vermeintlichen Nähe zur klinischen Situation der Gallensteinpankreatitis für viele Untersuchungen zur Pathogenese der AP, aber auch zur Evaluierung möglicher therapeutischer Ansätze herangezogen [3,8,22]. Durch die intraduktale Injektion einer Taurocholatlösung (3,5 %) in den gemeinsamen Gallen-Pankreas-Gang der Wistar-Ratte konnten wir einen signifikanten Anstieg der Aktivitäten von Amylase und Lipase im Effluat induzieren, während die LDH kontinuierlich auf einem niedrigen Niveau blieb.…”

Section: Materials Und Methodenunclassified

Enzymatische und histologische Veränderungen am isoliert perfundierten Pankreas der Ratte im Taurocholat- und Cerulein-Modell der akuten Pankreatitis

Schubert

Mantke²,

Pross³

et al. 2001

Zentralbl Chir

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Our data suggest that the isolated perfused rat pancreas (IPRP) is a valuable experimental tool to verify pathophysiological changes in the early phase of acute pancreatitis (AP). Various established models of AP such as by cerulein hyperstimulation or intraductal injection of taurocholate, could be applied to the IPRP. We conclude that this method enlarges the spectrum of established experimental models of acute pancreatitis.

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Free Radicals and Antioxidants in Pancreatic Inflammation

Sanfey¹

1991

Pancreatic Disease

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Parenteral Superoxide Dismutase Plus Catalase Diminishes Pancreatic Edema in Sodium Taurocholate-Induced Pancreatitis in the Rat

Cited by 17 publications

References 0 publications

Lipid Peroxidation and Glutathione Metabolism in Chronic Pancreatitis

Lipid Peroxidation and Glutathione Metabolism in Chronic Pancreatitis

Enzymatische und histologische Veränderungen am isoliert perfundierten Pankreas der Ratte im Taurocholat- und Cerulein-Modell der akuten Pankreatitis

Free Radicals and Antioxidants in Pancreatic Inflammation

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