Parenteral benadryl in allergy

Antihistamine Drugs

“…to 85 per cent. by various authors (Friedlaender, 1948; McGavack, et al, I948; Serafini, I948; Gay, et al, 1948;Waldbott and Young, 1948;Steinberg and Gottesman, 1948;Herxheimer, 1948;Friedlaender, 1949). Gay and his co-workers (I948), using dummy tablets as a control, claim over 50 per cent.…”

“…It has been shown that they vary widely in potency when tested against lethal doses of histamine. A standard protective dose of anthisan will protect guinea pigs against 124 lethal doses of histamine, whereas pyribenzamine protects against 37, benadryl against 5 and antistine against 2 (Friedlaender, 1948). Phenergan (Halpern, I947) is said to prevent the effect of 1,500 lethal doses of histamine compared with a comparable dose of anthisan which protects against 8o lethal doses.…”

“…to 2 per cent. solutions into the eye or the nose has been recommended in conjunctivitis or hay fever (Friedlaender, 1948;Brem and Zonis, I949;Zellen, 1949). Inhalation of 2 per cent.…”

Clinical Trials of Antihistaminic Drugs in Prevention and Treatment of the Common Cold

“…The available evidence indicated that thonzylamine would be the most appropriate choice in the first instance, as it was generally accepted as having a low toxicity (Friedlaender and Friedlaender, 1948 ;Criep and Aaron, 1948;Schwartz, 1949) and had been claimed as very effective against the common cold by Arminio and Sweet (1949) and Tebrock (1950).…”