Parenteral Antibiotics and Carbohydrate Intolerance in Term Neonates

Bhatia, Jatinder; Prihoda, Alton R; Richardson, C. Joan

doi:10.1001/archpedi.1986.02140160029022

Cited by 4 publications

(3 citation statements)

References 21 publications

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“…This study clearly demonstrates that development of microbial digestion together with rapid SCFA absorption is a primary feature responsible for the colonic compensation observed in the older pigs. The decrease of bacterial flora and thus the capacity to ferment dietary CHO that arrive in the colon can explain the diarrhea frequently observed in infants treated with broad spectrum antibiotics as demonstrated by Bhatia et al [10].…”

Section: Colonic Scavengers Of Unabsorbed Cromentioning

confidence: 97%

Role of colonic scavengers of unabsorbed carbohydrates in infants and children.

Lifschitz

1996

Journal of the American College of Nutrition

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The role of the colonic bacterial flora as scavenger of carbohydrate (CHO) in general and that of fruit juice in particular is reviewed. In the large bowel, CHO is fermented to short chain fatty acids (SCFA) and gas. SCFA are not produced in the immediate neonatal period when the fecal flora is still at the first stage of its development. Studies have demonstrated that mature animals have a compensatory response to diarrhea by increasing six times the capacity to absorb fluids in the large bowel compared to the younger animals; furthermore, CHO that arrives in the colon is completely fermented to SCFA while in the younger pigs CHO passes through the colon unchanged. As in the young pigs, a similar situation can occur in young children when a relatively large amount of CHO arrives in the large bowel.

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Section: Colonic Scavengers Of Unabsorbed Cromentioning

confidence: 97%

Role of colonic scavengers of unabsorbed carbohydrates in infants and children.

Lifschitz

1996

Journal of the American College of Nutrition

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“…This salvage route assumes even greater importance when considering patients with carbohydrate maldigestion due to immaturity (29a) or small intestinal mucosal injury (30). Antibiotic therapy may also interfere with this salvage mechanism and result in carbohydrate malabsorption (31).…”

Section: Intermediary Metabousm Of Colonic Mucosamentioning

confidence: 99%

Intestinal Mucosal Energy Metabolism‐A New Approach to Therapy of Gastrointestinal Disease

1990

J. pediatr. gastroenterol. nutr.

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“…Protein digestion by the colonic bacteria and absorption of N may also occur in the colon of neonates (Heine et al 1987). This dependence on the colonic microflora for nutrient absorption indicates a need to consider the effects of antibiotics on nutrition in small babies (Bhatia et al 1986).…”

mentioning

confidence: 99%

Interactions between nutrition and the intestinal microflora

Edwards

1993

Proc. Nutr. Soc.

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Parenteral Antibiotics and Carbohydrate Intolerance in Term Neonates

Cited by 4 publications

References 21 publications

Role of colonic scavengers of unabsorbed carbohydrates in infants and children.

Role of colonic scavengers of unabsorbed carbohydrates in infants and children.

Intestinal Mucosal Energy Metabolism‐A New Approach to Therapy of Gastrointestinal Disease

Interactions between nutrition and the intestinal microflora

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