Parenteral administration of different amounts of branch-chain amino acids in septic patients

Garcı́a-de-Lorenzo, Abelardo; Ortíz-Leyba, Carlos; Planas, M.; Montejo, Juan Carlos; Nuñez, Rafael N.; Ordóñez, Francisco Javier; Aragón, C Grande; Jiménez, F. J. Jiménez

doi:10.1097/00003246-199703000-00008

Cited by 89 publications

(42 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast, long lasting effects of BCAA supplementation were reported in patients with a metabolic or nutritional deficiency like in septic or cancer patients. In these patient groups BCAA supplementation was reported to result in positive effects on albumin status, quality of life and overall survival (Jimenez Jimenez et al, 1991;Garcia-de-Lorenzo et al, 1997;Surgery, 1997;Meng et al, 1999;Poon et al, 2004). Moreover, it has been reported that protein synthesis can only be stimulated in the presence of a high supply of balanced amounts of essential amino acids (Rooyackers and Nair, 1997).…”

Section: Discussionmentioning

confidence: 99%

“…Prospective caloric-and nitrogen-controlled trials of BCAA supplementation through TPN) in septic patients indeed resulted in an improvement of pre-albumin levels and a decreased overall mortality (Jimenez Jimenez et al, 1991;Garcia-de-Lorenzo et al, 1997). Anthony and co-workers showed in various rat models that leucine enhances protein synthesis in skeletal muscle through both insulin-dependent and -independent mechanisms (Anthony et al, 2002a, b).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Dietary supplementation with a specific combination of high protein, leucine, and fish oil improves muscle function and daily activity in tumour-bearing cachectic mice

et al. 2009

View full text Add to dashboard Cite

Cancer cachexia is characterised by metabolic alterations leading to loss of adipose tissue and lean body mass and directly compromises physical performance and the quality of life of cancer patients. In a murine cancer cachectic model, the effects of dietary supplementation with a specific combination of high protein, leucine and fish oil on weight loss, muscle function and physical activity were investigated. Male CD2F1 mice, 6 -7 weeks old, were divided into body weight-matched groups: (1) control, (2) tumourbearing, and (3) tumour-bearing receiving experimental diets. Tumours were induced by s.c. inoculation with murine colon adenocarcinoma (C26) cells. Food intake, body mass, tumour size and 24 h-activity were monitored. Then, 20 days after tumour/ vehicle inoculation, the animals were killed and muscle function was tested ex vivo. Tumour-bearing mice showed reduced carcass, muscle and fat mass compared with controls. EDL muscle performance and total daily activity were impaired in the tumour-bearing mice. Addition of single nutrients resulted in no or modest effects. However, supplementation of the diet with the all-in combination of high protein, leucine and fish oil significantly reduced loss of carcass, muscle and fat mass (loss in mass 45, 52 and 65% of TB-con, respectively (Po0.02)) and improved muscle performance (loss of max force reduced to 55 -64% of TB-con (Po0.05)). Moreover, total daily activity normalised after intervention with the specific nutritional combination (50% of the reduction in activity of TB-con (Po0.05)). In conclusion, a nutritional combination of high protein, leucine and fish oil reduced cachectic symptoms and improved functional performance in cancer cachectic mice. Comparison of the nutritional combination with its individual modules revealed additive effects of the single components provided.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Dietary supplementation with a specific combination of high protein, leucine, and fish oil improves muscle function and daily activity in tumour-bearing cachectic mice

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Furthermore, BCAAs (especially leucine) are known to stimulate muscle protein synthesis and to inhibit protein breakdown (20). Therefore, BCAAs may be beneficial nutrients for septic patients (6). From these backgrounds, we were particularly interested in analyzing the dynamics of plasma BCAA concentrations after peroral or parenteral administration of BCAAs.…”

Section: Effects Of Lps Treatment On the Dynamics Of Plasma Free Bcaamentioning

confidence: 99%

The Effects of Endotoxin on Plasma Free Amino Acid Concentrations in Rats

Asai

Bajotto

Yoshizato

et al. 2008

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

SummaryWe examined the effects of lipopolysaccharide (LPS) injection on body temperature and plasma free amino acid concentrations in rats. A catheter was placed in the jugular vein of the rats in order to draw blood from and to inject LPS into awake animals. On the day of the experiment, body temperature was recorded during the experiment (330 min) and blood was drawn before and at several time points after injection of LPS (10 g/kg body weight). Body temperature in LPS-treated rats began to rise ~30 min after injection with a peak at 120 min, and afterward remained ~1˚C higher than that in control rats through the end of the experiment. Concentrations of many plasma free amino acids were decreased by LPS treatment, with a nadir at ~120 min, and then were increased to the level of or over the control. It appears that thermoregulatory responses induced by LPS treatment may be related to alterations in plasma free amino acid concentrations. Effects of LPS treatment on the dynamics of plasma free branched-chain amino acid (BCAA) concentrations in rats with peroral or intravenous administration of BCAAs were also examined. The results showed that the rise in plasma BCAA concentrations after peroral BCAA administration was significantly suppressed by LPS treatment, but the dynamics of plasma BCAAs after intravenous administration was not affected by LPS, suggesting that LPS treatment inhibited the intestinal absorption of BCAAs into the circulation. These results suggest that the availability of administered BCAAs to the body tissues during sepsis is higher following parenteral than peroral administration. Key Words endotoxin, lipopolysaccharide, plasma amino acids, branched-chain amino acids (BCAA), body temperature Sepsis induces several metabolic responses including negative nitrogen balance and loss of lean body mass. This catabolic phase is associated with muscle protein breakdown ( 1 , 2 ) and increased whole body amino acid metabolism ( 3 ). Glutamine metabolism and branchedchain amino acid (BCAA) catabolism are especially prominent; glutamine production is increased through proteolysis and BCAAs are actively oxidized in skeletal muscles during sepsis ( 4 , 5 ). Therefore, administration of these amino acids is considered to have a potential to alleviate the septic conditions ( 6 , 7 ).Administration of bacterial lipopolysaccharide (LPS) preparations to laboratory animals is widely used to reproduce the septic state, in which various metabolic as well as thermoregulatory responses are induced in association with systemic inflammation. It has been reported that the thermoregulatory response to LPS administration is dependent upon the dose of LPS and ambient temperature ( 8 ). In many studies ( 5 , 9 -12 ), high, shock-inducing doses such as 500 g LPS/kg body weight (BW) or more have been used and these doses caused pronounced hypothermia ( 8 ). On the other hand, it has been reported that intravenous administration of low or intermediary doses (less than 10 g/kg BW) of LPS elicits fever when animals are kept i...

show abstract

“…These properties make their use in amino acid-enriched solutions theoretically appropriate for the management of the metabolic alterations that occur in sepsis. Forty-ive percent branched-chain amino acid-enriched solutions have been suggested to intensify synthesis of proteins in the liver [19] and proteins whose plasma levels are elevated or reduced (acute-phase proteins) during severe illness [20]. Because acute-phase proteins might play vital roles in a septic patient's defence mechanisms against infections, the administration of solutions containing high amounts of BCAAs may increase the likelihood of quick recovery and survival for such patients [19].…”

Section: Branched-chain Amino Acidsmentioning

confidence: 99%

Therapeutic Uses of Amino Acids

Odia¹,

Esezobor²

2017

Amino Acid - New Insights and Roles in Plant and Animal

View full text Add to dashboard Cite

Amino acids, which are the building blocks of peptides and proteins, are indispensable chemicals needed by the body for optimal metabolism and proper body functioning. Classiied as essential, nonessential and conditionally essential, amino acids play vital roles in the body such as in protein synthesis and as precursors in the production of secondary metabolism molecules. Amino acid oxygenases also play vital metabolic roles such as in prevention of diseases; as a result, amino acids and their oxygenases isolated from various organisms are potent candidates in treatment of diseases which include cancers, inlammations, as well as antibacterial agents.

show abstract

Parenteral administration of different amounts of branch-chain amino acids in septic patients

Abstract: Our results suggest that the branch-chain amino acids-rich formulas (45%) show a beneficial effect in septic patients.

Cited by 89 publications

References 47 publications

Dietary supplementation with a specific combination of high protein, leucine, and fish oil improves muscle function and daily activity in tumour-bearing cachectic mice

Dietary supplementation with a specific combination of high protein, leucine, and fish oil improves muscle function and daily activity in tumour-bearing cachectic mice

The Effects of Endotoxin on Plasma Free Amino Acid Concentrations in Rats

Therapeutic Uses of Amino Acids

Contact Info

Product

Resources

About