Parental Transmission Plays the Major Role in High Aggregation of Type 2 Diabetes in Iranian Families: Tehran Lipid and Glucose Study

Akbarzadeh, Mahdi; Riahi, Parisa; Ramezankhani, Azra; Dehkordi, Saeid Rasekhi; Roudbar, Mahmoud Amiri; Zarkesh, Maryam; Guity, Kamran; Khalili, Davood; Zahedi, Asiyeh Sadat; Azizi, Fereidoun; Daneshpour, Maryam Sadat

doi:10.1016/j.jcjd.2021.05.009

Cited by 5 publications

(5 citation statements)

References 32 publications

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“…We consistently found mild to moderate ranges of proband-sibling resemblance across the majority of affective symptoms (ICC range: 0.10-0.21; Chapters 3 and 5), psychosocial vulnerabilities (ICC range: 0.11-0.32; Chapter 3), and immunometabolic health (ICC range: 0.14-0.25; Chapter 5). This is in accordance with previous studies conducted within NESDA and other studies in (older) adult samples (Akbarzadeh et al, 2022;. Specifically, the comparable ranges in ICCs across feature domains indicates that siblings from the same family show a similar degree of resemblance in a wide variety of different Despite their familial disposition and enhanced social and cognitive vulnerability, half of the siblings of patients with lifetime affective disorders were unaffected.…”

Section: Rq3 To What Extent Are Affective Symptoms Psychosocial Vulne...supporting

confidence: 92%

“…emotional maltreatment; , and immunometabolic diseases (e.g. cardiovascular disease, diabetes mellitus, rheumatoid arthritis; Akbarzadeh et al, 2022; and biomarkers (e.g. HDL-cholesterol; , although small estimates have also been reported (i.e.…”

Section: Sibling Resemblance In Affective Symptoms Psychosocial Vulne...mentioning

confidence: 99%

“…Affective disorders and somatic diseases cluster within families, with studies showing moderate resemblance between siblings for affective symptoms and moderate to large resemblance for somatic diseases (e.g. cardiovascular disease) (Akbarzadeh et al, 2022; and biomarkers (e.g. high-density lipoprotein [HDL]-cholesterol) .…”

Section: Introductionmentioning

confidence: 99%

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Familial risk for depression and anxiety

Sprang¹

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Background Family history of affective disorders has long been recognized as one of the strongest risk factors for the onset and maintenance of the disorders. Familial risk for affective disorders represents an integration of an underlying genetic vulnerability and the familial clustering of unfavorable family circumstances in (early) life. In order to alleviate some of the burden that affective disorders are causing, it is necessary to better understand how the disorders and their associated features operate within families to increase psychopathology. This thesis extensively examined familial risk for affective disorders, with a broad focus on the role of genetic, clinical, and psychosocial vulnerability, and poor immunometabolic health. Methods Data came from the Netherlands Study of Depression and Anxiety (NESDA), an ongoing longitudinal cohort study (2004-present) on the long-term course and consequences of affective disorders. The baseline sample consisted of 2,981 participants (18-65 years), including 2,319 persons with a lifetime affective disorder and 652 healthy controls. Participants were assessed in face-to-face interviews at baseline and 2-, 4-, 6-, and 9-year follow-up. Among a broad range of demographic, psychiatric, genetic, and biopsychosocial measures, the 9-year follow-up included a detailed family history assessment; 1,425 lifetime affected NESDA participants had valid family history data. During the 9-year follow-up, full-biological siblings of NESDA participants with a lifetime affective disorder (i.e. ‘probands’) were additionally recruited to participate in the NESDA sibling study. This included a total of 380 siblings, related to 256 probands (N = 636 from 256 families). Discussion of main findings Lifetime affected patients with higher familial risk showed higher genetic vulnerability and a more unfavorable disease and psychosocial risk profile. Although a dichotomous family history measure is an informative indicator, familial risk for affective disorders seems to be better captured by a continuous score that incorporates family- and disorder-specific characteristics. Furthermore, prevalence of current (26.8%) and lifetime (50.3%) affective disorders in siblings of lifetime affected probands was substantial, and two- to three- times higher as compared to Dutch population frequencies. As compared to healthy controls without affected relatives, probands’ unaffected siblings showed enhanced social vulnerability and rumination. Despite this, the majority of affective symptoms and psychosocial vulnerabilities were, in fact, not elevated in unaffected siblings as compared to healthy controls, which may indicate their underlying resilience. Moreover, proband-sibling resemblance in affective symptoms, psychosocial vulnerability, and poor immunometabolic health was mild to moderate, indicating that these features, to a certain extent, cluster within families, but that lifetime affected patients and their siblings still show considerable individual differences despite their shared familial disposition. Finally, between siblings of the same at-risk family, cross-trait associations of affective symptoms appear to be relevant in the link with psychosocial vulnerability, but less in the link with poor immunometabolic health. Concluding remarks Findings illustrate that familial risk for affective disorders is a complex and dimensional construct that deserves attention in research and clinical practice. Having identified a wide variety of clinically-relevant factors that may explain heightened familial risk, the next generation of research should focus on preventing the onset of affective disorders and fostering resilience in at-risk relatives. Both within research and clinical practice, it is of particular importance to direct attention to family members when evaluating the risk for affective disorders, as this may contribute to a better understanding of the role of within-family processes in the etiology and maintenance of the disorders, and help identify pathways through which resilience is promoted. This knowledge may ultimately contribute to more effective treatment, the early identification of affective problems, and possibly preventing new onset of disorder, severe disability and intensive treatment in those at the highest risk.

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Section: Rq3 To What Extent Are Affective Symptoms Psychosocial Vulne...supporting

confidence: 92%

Section: Sibling Resemblance In Affective Symptoms Psychosocial Vulne...mentioning

confidence: 99%

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Familial risk for depression and anxiety

Sprang¹

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“…Tehran Cardiometabolic Genetic Study (TCGS) is a family-based genetic database according to a larger strudy, Tehran Lipid and Glucose Study (TLGS) (11)(12)(13). TLGS is a population-based cohort started in 1999, and study subjects have been followed up through six phases (every three years) on non-communicable disorders' (NCDs) and related risk factors (14).…”

Section: Study Participants and Study Designmentioning

confidence: 99%

The AGT epistasis pattern proposed a novel role for ZBED9 in regulating blood pressure: Tehran Cardiometabolic genetic study (TCGS)

Akbarzadeh

Riahi

Kolifarhood

et al. 2022

Gene

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“…In Saudi population, type 2 diabetes is correlated with consanguinity particularly among the offspring of first-cousin marriages (Alzahrani et al ., 2021). The heritability of type 2 diabetes with a polygenic mode in Iranian population is higher than the global average, and the risk of developing this type of diabetes is higher in individuals with affected first-cousin parents than in individuals with affected second-cousin parents (Akbarzadeh et al ., 2022).…”

Section: Introductionmentioning

confidence: 99%

The practice of consanguineous marriage and the risk of diabetes among offspring in the province of Tetouan (Morocco)

Hajjaji

Khadmaoui²,

Bakkali³

2023

AGJSR

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PurposeThe practice of consanguinity has been culturally preferred in most Arab countries, including Morocco. This behavior leads to an increase in genetic abnormalities, such as hypertension and diabetes. This paper examines the prevalence and determinants of first-cousin marriages and their impact on diabetes among offspring.Design/methodology/approachData on 882 couples were collected through face-to-face interview via a pre-established questionnaire based on the variables selected within the objectives of this study. The authors used the multiple logistic regression modeling procedure in this study.FindingsThe results of the study indicate that the prevalence of first-cousin marriages were 15% among students’ parents. From the multiple logistic regression modeling, the authors found a significant effect of paternal and maternal grandparents’ first-cousins marriage on that of parents (aOR = 3.27 and aOR = 3.36, respectively). However, an 11-fold higher risk of first relative marriages among parents once the paternal and maternal grandparents were first-cousins and the father was illiterate (aOR = 11.01). Moreover, the authors reported a diabetes risk of more than 14 times when the effects of first-cousin maternal grandparents and parents and the hypertension among mother or her sibling were combined (aOR = 14.48) or when the effects of first-cousins maternal grandparents, first-cousin parents and mother’s age at marriage between 21 and 29 years were combined (aOR = 14.56).Originality/valueFirst-cousin marriage depends on the father’s illiteracy and the consanguinity of grandparents’ factors. The cumulative effect of first-cousin marriage among grandparents, parents and a family history of hypertension among mother or her sibling increase the risk of diabetes among these mothers.

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Parental Transmission Plays the Major Role in High Aggregation of Type 2 Diabetes in Iranian Families: Tehran Lipid and Glucose Study

Cited by 5 publications

References 32 publications

Familial risk for depression and anxiety

Familial risk for depression and anxiety

The AGT epistasis pattern proposed a novel role for ZBED9 in regulating blood pressure: Tehran Cardiometabolic genetic study (TCGS)

The practice of consanguineous marriage and the risk of diabetes among offspring in the province of Tetouan (Morocco)

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