Parental tobacco smoking and risk of childhood leukemia in Costa Rica: A population-based case-control study

Frederiksen, Line Elmerdahl; Erdmann, Friederike; Wesseling, Catharina; Winther, Jeanette Falck; Mora, Ana M.

doi:10.1016/j.envres.2019.108827

Cited by 18 publications

(13 citation statements)

References 56 publications

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“…Several confounders were taken into account based on variables that are associated with modes of conception and can affect childhood cancers: maternal age 32,33 ; paternal age 32,34 ; maternal addiction to tobacco, alcohol, or drugs [35][36][37] ; parity 14,16 ; abortion history (ICD-9-CM: 630-639; ICD-10-CM: O00-O08) 38,39 ; socioeconomic status 38,40 ; parental cancer history; and residential urbanization level. 41 A proxy for parental socioeconomic status was household income at birth, calculated by the National Health Insurance program, which covers 99.6% of Taiwan's residents.…”

Section: Potential Confounders and Mediatorsmentioning

confidence: 99%

Assisted Reproductive Technology and Risk of Childhood Cancers

Weng

Huang

et al. 2022

JAMA Netw Open

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IMPORTANCEThe number of children born through the use of assisted reproductive technology (ART) has been increasing. These children may have higher risks for epigenetic alteration and adverse perinatal outcomes, which may be associated with childhood cancers. OBJECTIVETo determine the associations between different modes of conception and childhood cancers and potential mediation by preterm birth and low birth weight.

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Section: Potential Confounders and Mediatorsmentioning

confidence: 99%

Assisted Reproductive Technology and Risk of Childhood Cancers

Weng

Huang

et al. 2022

JAMA Netw Open

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“…Other factors suspected of increasing the risk of childhood cancer include chromosomal and non-chromosomal congenital anomalies, [13] in utero or postnatal environmental exposures to e.g. pesticides, dichloromethane, and other chemicals, [14] , [15] , [16] high parental age, [17] , [18] , [19] , [20] caesarean delivery, [21] fertility treatment by frozen embryo transfer, [22] lack of immune system stimulation,[ 23 , 24 ] and parental lifestyle such as paternal smoking and maternal coffee consumption [25] , [26] , [27] , [28] , [29] . Studies of parental socioeconomic status in relation to childhood cancers have reported inconsistent results [30] , [31] , [32] .…”

Section: Introductionmentioning

confidence: 99%

Air pollution exposure at the residence and risk of childhood cancers in Denmark: A nationwide register-based case-control study

et al. 2020

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Background The etiology of childhood cancer is poorly understood. The role of environmental factors, including air pollution (AP) exposure, has been addressed previously, but results so far have been inconclusive. In this study, we investigate the association between long-term AP exposures in relation to childhood cancer subtypes in Denmark (1981–2013). Methods We conducted a nationwide register-based case-control study. We identified 7745 incident cases of childhood cancers (<20 years) in the Danish Cancer Registry. Four randomly selected (cancer-free) controls were matched to each case according to sex and date of birth. We modelled concentrations of nitrogen dioxide (NO 2 ), fine particles (PM 2·5 ), and black carbon (BC) at all addresses and calculated a time-weighted average from birth to index-date with a state-of-the-art multiscale AP modelling system. We analyzed the risk of childhood cancer in conditional logistic regression models adjusted for socio-demographic variables obtained from registers at the individual and neighborhood level. Findings The main analyses included 5045 cases and 18,179 controls. For all cancers combined, we observed odds ratios (ORs) and 95% confidence intervals (95% CI) of 0·97 (0·94, 1·01) per 10 µg/m 3 NO 2 , 0·89 (0·82, 0·98) per 5 µg/m 3 PM 2·5 , and 0·94 (0·88, 1·01) per 1 µg/m 3 BC, respectively. Most notably, we observed a higher risk of Non-Hodgkin Lymphoma (NHL) with higher childhood AP exposure with ORs and 95% CIs of 1·21 (0·94, 1·55) per 10 µg/m 3 NO 2 , 2·11 (1·10, 4·01) per 5 µg/m 3 PM 2·5 , and 1·68 (1·06, 2·66) per 1 µg/m 3 BC, respectively. We observed indications of increased risks for other types of childhood cancer, however, with very wide CIs including 1. Interpretations The findings of this nation-wide study propose a role of AP in the development of childhood NHL, but more large-scale studies are needed. Funding NordForsk Project #75007.

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Section: Introductionmentioning

confidence: 99%

“…A study showed that paternal smoking is significantly related to childhood leukemia and can increase the risk of this disease. [6,7] Another study showed that paternal smoking can cause obesity in offspring. [8] As one of the main harmful substances in cigarettes, nicotine can also alter the phenotype of offspring.…”

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confidence: 99%

Nicotine exposure of male mice protects offspring against carbon tetrachloride‐induced acute liver injury

Zhang

Dai

Cao

et al. 2022

J Biochem & Molecular Tox

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Paternal nicotine exposure can cause a phenotypic change in offspring. To study whether paternal nicotine exposure influences acute liver injury and repair of the offspring, we established a paternal nicotine exposure model in mice and treated the offspring mice with carbon tetrachloride (CCl 4 ) to induce acute liver injury. After the treatment of CCl 4 , the levels of alanine aminotransferase and aspartate aminotransferase in offspring serum of paternal nicotine exposed mice are about 37.44%, and 30.21% lower than the control mice, respectively. Transcription profiling screen and bioinformatics analysis of differently expressed genes in F1 mice liver revealed that the Wnt pathway was altered. The results demonstrate that nicotine exposure in male mice could enhance the activation of the Wnt pathway in F1 mice liver. The Wnt pathway facilitates cell proliferation and tissue repair. In conclusion, our findings showed that nicotine exposure of male mice protects hepatic against CCl 4 -induced acute injury in offspring by activating the Wnt pathway in the F1 liver.

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Parental tobacco smoking and risk of childhood leukemia in Costa Rica: A population-based case-control study

Cited by 18 publications

References 56 publications

Assisted Reproductive Technology and Risk of Childhood Cancers

Assisted Reproductive Technology and Risk of Childhood Cancers

Air pollution exposure at the residence and risk of childhood cancers in Denmark: A nationwide register-based case-control study

Nicotine exposure of male mice protects offspring against carbon tetrachloride‐induced acute liver injury

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