Parental Reports of Psychological Adjustment and Social Competence in Child Survivors of Acute Lymphocytic Leukemia

Shelby, Meghan D.; Nagle, Richard J.; Barnett-Queen, Laura L.; Quattlebaum, Patricia D.; Wuori, Donald F.

doi:10.1207/s15326888chc2702_3

Cited by 24 publications

(19 citation statements)

References 24 publications

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“…Kanellopoulos et al [23] reported that levels of anxiety and depression remained significantly associated with poor quality of life. Although major psychiatric disturbances are not common among survivors of ALL, a few earlier studies showed that this population has increased risk for mental health and adjustment problems [24,25,26]. Some studies indicate that the period after treatment is characterized by a higher risk of psychosocial problems compared with the actual treatment period.…”

Section: Discussionmentioning

confidence: 99%

Health-Related Quality of Life, Depression, Anxiety, and Self-Image in Acute Lymphocytic Leukemia Survivors

Baytan

Aşut²,

Kantarcıoğlu³

et al. 2016

Tjh

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Objective:With increasing survival rates in childhood acute lymphocytic leukemia (ALL), the long-term side effects of treatment have become important. Our aim was to investigate health-related quality of life, depression, anxiety, and self-image among ALL survivors.Materials and Methods:Fifty patients diagnosed with ALL and their siblings were enrolled. The Kovacs Children’s Depression Inventory, State-Trait Anxiety Inventory, Offer Self-Image Questionnaire, and Pediatric Quality of Life InventoryTM were used for collecting data. ANOVA tests were used to determine if there were any significant differences between groups.Results:ALL survivors had higher depression, more anxiety symptoms, lower quality of life, and more negative self-image when compared to their siblings.Conclusion:Continuous diagnostic and interventional mental health services might be necessary for possible emotional side effects of treatment during and after the treatment. Rehabilitation and follow-up programs should be implemented for children during and after treatment for ALL.

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Section: Discussionmentioning

confidence: 99%

Health-Related Quality of Life, Depression, Anxiety, and Self-Image in Acute Lymphocytic Leukemia Survivors

Baytan

Aşut²,

Kantarcıoğlu³

et al. 2016

Tjh

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“…Adolescent survivors of ALL often manifest higher levels of anxiety in the wake of the disease than their healthy peers (Shelby et al, 1998). Given that the recurrence of ALL remains a significant challenge to medical management of the disease (Nahar & Müschen, 2009), the present results raise the possibility that cancer-related anxiety might contribute to disease recurrence and that pharmacologic inhibition of such effects at the level of the β-adrenergic receptor may represent an effective strategy for managing those effects in patients with pre-B ALL who are in remission or still have active disease.…”

Section: Discussionmentioning

confidence: 99%

Chronic stress enhances progression of acute lymphoblastic leukemia via β-adrenergic signaling

Lamkin

Sloan

Patel

et al. 2012

Brain, Behavior, and Immunity

116

102

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Clinical studies suggest that stress-related biobehavioral factors can accelerate progression of hematopoietic cancers such as acute lymphoblastic leukemia (ALL), but it is unclear whether such effects are causal or what biological pathways mediate such effects. Given the network of sympathetic nervous system (SNS) fibers that innervates the bone marrow to regulate normal (non-leukemic) hematopoietic progenitor cells, we tested the possibility that stress-induced SNS signaling might also affect ALL progression. In an orthotopic mouse model, Nalm-6 human pre-B ALL cells were transduced with the luciferase gene for longitudinal bioluminescent imaging and injected i.v. into male SCID mice for bone marrow engraftment. Two weeks of daily restraint stress significantly enhanced ALL tumor burden and dissemination in comparison to controls, and this effect was blocked by the β-adrenergic antagonist, propranolol. Although Nalm-6 ALL cells expressed mRNA for β1- and β3-adrengeric receptors, they showed no evidence of cAMP signaling in response to norepinephrine, and norepinephrine failed to enhance Nalm-6 proliferation in vitro. These results show that chronic stress can accelerate the progression of human pre-B ALL tumor load via a β-adrenergic signaling pathway that likely involves indirect regulation of ALL biology via alterations in the function of other host cell types such as immune cells or the bone marrow microenvironment.

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“…Adolescents who were forced to rely on their parents to a greater extent than same-age peers might experience a sense of separation anxiety when they finally have the opportunity for greater autonomy. Likewise, adolescents may experience social anxiety in relation to the social deficits found by Barrera and colleagues (2005) and Shelby and colleagues (1998). These examples are only a few of the ways that anxiety could potentially manifest in adolescent survivors of pediatric cancer.…”

Section: Implications For Research and Practicementioning

confidence: 99%

Anxiety among adolescent survivors of pediatric cancer: A missing link in the survivorship literature

et al. 2014

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Objective With growing numbers of pediatric cancer survivors, it is becoming increasingly important to investigate the psychosocial sequelae of surviving cancer diagnosed during childhood or adolescence. It is particularly important to study the psychosocial needs of adolescent survivors of pediatric cancer because adolescence is a critical time during psychosocial development. Although there is existent literature about the general psychosocial adjustment of this population, the literature regarding anxiety is scant. This brief review aimed to assesses currently available literature that addresses anxiety in adolescent cancer survivors. Method Articles assessing psychosocial adjustment in adolescent survivors of pediatric cancer were reviewed for information regarding anxiety symptoms. Results To the authors’ knowledge, there is no literature that focuses specifically on anxiety in this population. However, many of the articles reported results that indicated the possibility of increased anxiety in this group. Significance of Results It is critical to further investigate anxiety in this group and to develop appropriate interventions if necessary. Doing so will aid the process of enhancing psychosocial care for adolescent cancer survivors.

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Parental Reports of Psychological Adjustment and Social Competence in Child Survivors of Acute Lymphocytic Leukemia

Cited by 24 publications

References 24 publications

Health-Related Quality of Life, Depression, Anxiety, and Self-Image in Acute Lymphocytic Leukemia Survivors

Health-Related Quality of Life, Depression, Anxiety, and Self-Image in Acute Lymphocytic Leukemia Survivors

Chronic stress enhances progression of acute lymphoblastic leukemia via β-adrenergic signaling

Anxiety among adolescent survivors of pediatric cancer: A missing link in the survivorship literature

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