Parental predictors of pediatric panic disorder/agoraphobia: a controlled study in high-risk offspring

Biederman, Joseph; Petty, Carter R.; Faraone, Stephen V.; Hirshfeld‐Becker, Dina R.; Henin, Aude; Dougherty, Bradley E; LeBel, Teresa J.; Pollack, Mark H.; Rosenbaum, Jerrold F.

doi:10.1002/da.20122

Cited by 16 publications

(7 citation statements)

References 27 publications

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“…Therefore, SAD may be particularly relevant to cognitive functioning for this age range given that it is most commonly observed during this time. Research also supports that SAD may be particularly important during this developmental period as it is the most commonly identified childhood disorder that predicts later psychopathology, specifically increased risk for experiencing a range of internalizing disorders (Biederman et al 2005; Biederman et al 2007). Second, estimates suggest that nearly 50% of 8-year-old children endorse sub-threshold SAD symptoms that do not cause clinically significant impairment (Figueroa et al 2012).…”

Section: Discussionmentioning

confidence: 91%

Associations between Disorder-Specific Symptoms of Anxiety and Error-Monitoring Brain Activity in Young Children

Schroder

Fisher

et al. 2016

J Abnorm Child Psychol

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Anxiety disorders are among the earliest emerging disorders and most common mental health problem across the lifespan. A common characteristic of individuals with anxiety is poor attentional and cognitive control. Therefore, researchers are interested in how cognitive functioning relates to anxiety in young children. In particular, research has demonstrated associations between anxiety and electrophysiological markers of cognitive control skills such as the error-related negativity (ERN). The nature of the anxiety-ERN relationship is not well understood, however. The purpose of the present study was to examine: 1) the association between the ERN and diagnostically-defined symptoms of different anxiety disorders; and 2) the extent to which disorder-specific symptoms of anxiety moderated the association between ERN and behavioral performance on a Go/No-Go task in a sample of 139 children 5–8 years of age (70 females and 69 males). Results suggest that more separation anxiety disorder (SAD) symptoms are associated with a smaller ΔERN, even after controlling for other anxiety disorder symptoms. Children with more SAD symptoms showed higher error rates and failed to exhibit the expected association between ΔERN and behavioral performance, suggesting ineffective error-monitoring in young children with SAD problems.

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Section: Discussionmentioning

confidence: 91%

Associations between Disorder-Specific Symptoms of Anxiety and Error-Monitoring Brain Activity in Young Children

Schroder

Fisher

et al. 2016

J Abnorm Child Psychol

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“…We failed to find significant effects that suggest an earlier onset of familial PD or AG, which is claimed to be a marker of a familial subtype in some studies [Battaglia et al, 1995;Goldstein et al, 1997;Venturello et al, 2002] but not in others [Biederman et al, 2005]. To overcome the shortcomings of earlier studies, which reported familial aggregation including comorbid cases, we aimed to investigate whether either of the disorders alone would be associated with higher disorder frequencies in offspring.…”

Section: Familial Aggregation Of Panic and Agoraphobia Without Diagnomentioning

confidence: 85%

Differential familial liability of panic disorder and agoraphobia

et al. 2008

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To examine the familial liability of panic disorder (PD) and agoraphobia (AG) in a community sample, namely the effect of parental PD and AG on the offspring's risk to develop either or both conditions in adolescence or adulthood. A representative community sample of N=3,021 adolescents and young adults aged 14-24 years at baseline was followed up over a period of 10 years in up to four waves. Family information was assessed by either direct interviews with at least one parent or by using subjects' family history information at either wave (N=3,014). Diagnoses and selected symptoms were assessed in both, parents and subjects, by using a standardized diagnostic interview (DSM-IV M-CIDI) with its respective family history module. (1) Parental panic attacks (PA), PD, and AG were all shown to be associated with an increased risk of offspring to also develop PA, PD, and AG. (2) Associations of parental PD were present irrespective of parental AG, whereas parental AG without PD was not associated with an increased offspring risk. (3) Outcome risk was particularly elevated in offspring of parents with PD+AG. (4) Parental PD or AG was not associated with an earlier age of onset of any syndrome in the offspring. We confirmed and expanded previous results from clinical samples that comorbid PD and AG aggregate in families. AG without PD is not familial, but it might enhance the familial transmission of PD.

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“…To our knowledge, such analyses have only rarely been presented. 3,15 Interestingly, offspring differing in maternal anxiety status did not differ in age at first onset of anxiety, possibly because phobias in particular develop relatively early in life, irrespective of family history. Elevated rates of anxiety disorders in the children were observed only when the mother met the diagnostic criteria for anxiety disorders with the three clinical characteristics.…”

Section: Discussionmentioning

confidence: 98%

Anxiety disorders in mothers and their children: Prospective longitudinal community study

et al. 2008

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The relationship between DSM-IV anxiety disorders and their clinical characteristics in mothers and anxiety in offspring was examined in 933 mother-child pairs from a longitudinal community study. Offspring of mothers with an anxiety disorder had an elevated risk of developing any anxiety disorder, compared with offspring of mothers with no anxiety disorder. Increased risk of anxiety in the offspring was especially associated with maternal social phobia and generalised anxiety disorder, and with maternal diagnoses of early onset, greater number and more severe impairment. These results suggest that the type of maternal anxiety disorder and its severity of manifestation contribute to mother-offspring aggregation of anxiety.

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Parental predictors of pediatric panic disorder/agoraphobia: a controlled study in high-risk offspring

Cited by 16 publications

References 27 publications

Associations between Disorder-Specific Symptoms of Anxiety and Error-Monitoring Brain Activity in Young Children

Associations between Disorder-Specific Symptoms of Anxiety and Error-Monitoring Brain Activity in Young Children

Differential familial liability of panic disorder and agoraphobia

Anxiety disorders in mothers and their children: Prospective longitudinal community study

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