Parental preconception exposure to phenol and phthalate mixtures and the risk of preterm birth

Mustieles, Vicente; Williams, Paige L.; Wylie, Blair J.; Souter, Irene; Calafat, Antònia M.; Demokritou, Melina; Lee, Alexandria; Vagios, Stylianos; Hauser, Russ; Messerlian, Carmen

doi:10.1016/j.envint.2021.106440

Cited by 47 publications

(23 citation statements)

References 104 publications

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“…Additionally, a prospective cohort study observed the combined effects of PM 10 and NO 2 in early pregnancy, and the combined effect of Pb and Hg in late pregnancy, were associated with reduced birth weight (Lee et al 2020). Zhang and his colleagues found a positive joint effect of prenatal phenol and phthalate exposure on PTB (Zhang et al 2021). Another study reported the potential synergistic interaction between Zn and Cu on PTB (Liu et al 2022).…”

Section: Joint Of Prenatal Exposure To Ve Sources Hap On Ptbmentioning

confidence: 96%

Joint effects of prenatal household air pollution exposure from multiple sources on preterm birth - A case-control study with propensity score matching

Liu

Strodl

Yang

et al. 2022

Preprint

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Prenatal exposure to household air pollution (HAP) has been suggested as a major risk factor for preterm birth (PTB). However, the effects of simultaneous prenatal exposure to multiple HAP sources on PTB have rarely been studied. We therefore conducted a case-control study on 21995 mother-child dyads after propensity score matching (PSM). After PSM, a series of logistic regression analysis on associations of environmental tobacco smoke (ETS), cooking oil fumes (COFs), burning mosquito coil (BMC), indoor burning incense (IBI) and household renovation (HR) with PTB were conducted to evaluate their independent and joint effects on PTB. Compared to mothers without exposure, prenatal exposure to each individual HAP source increased the PTB risk. Moreover, the accumulative effects of prenatal exposure to five sources of HAP on the risk of PTB were observed. Finally, we found synergistic effects between prenatal exposure to COFs and IBI, as well as between BMC and IBI, on PTB on both multiplicative and additive scales. Our results suggest that prenatal exposure to different sources of HAP might increase the risk of PTB and that accumulative effects, as well as synergistic interactions, between different HAP sources on PTB might exist.

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Section: Joint Of Prenatal Exposure To Ve Sources Hap On Ptbmentioning

confidence: 96%

Joint effects of prenatal household air pollution exposure from multiple sources on preterm birth - A case-control study with propensity score matching

Liu

Strodl

Yang

et al. 2022

Preprint

View full text Add to dashboard Cite

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“…Based on the Shanghai Birth Cohort (SBC), a total of 938 couples trying for pregnancy were included in the present study to explore the variations in PFAS exposure within and between couples. Preconception exposure merits close attentions as it could constitute a susceptible period for the potential impact of environmental chemicals on adverse birth outcomes . Our main objectives were to (1) characterize PFAS exposure in preconception couples and the relationships and variations in exposure profiles within couples; and (2) explore between-couple variations and the factors affecting couple-based FPAS exposure.…”

Section: Introductionmentioning

confidence: 99%

“…Preconception exposure merits close attentions as it could constitute a susceptible period for the potential impact of environmental chemicals on adverse birth outcomes. 14 Our main objectives were to (1) characterize PFAS exposure in preconception couples and the relationships and variations in exposure profiles within couples; and (2) explore between-couple variations and the factors affecting couple-based FPAS exposure. Our work constitutes one of the few studies addressing preconception couple exposure to PFAS and lays a solid ground for further assessment of the impacts of preconception exposure on reproductive health.…”

Section: ■ Introductionmentioning

confidence: 99%

Exposure of Preconception Couples to Legacy and Emerging Per- and Polyfluoroalkyl Substances: Variations Within and Between Couples

Liu

Luo

Zhang

et al. 2022

Environ. Sci. Technol.

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Exploration of the exposure of preconception couples to per- and polyfluoroalkyl substances (PFAS), as well as the most important influencing factors, promotes the understanding of the joint effects of parental exposure on reproductive health. In the present study, a total of 938 preconception couples recruited through the Shanghai Birth Cohort were investigated for the variations of PFAS exposure and contributing factors within and between couples. While linear perfluorooctanoic acid (n-PFOA, median 20.4 ng/mL) and linear perfluorooctanesulfonic acid (n-PFOS, 12.1 ng/mL) remained dominant in plasma, emerging PFAS, particularly 6:2 chlorinated polyfluorinated ether sulfonate (10.5 ng/mL), 6:2 polyfluoroalkyl phosphate diester (0.41 ng/mL), and branched PFOS or PFOA isomers, were also frequently detected. Although individual PFAS were generally correlated within couples, gender differences significantly existed in the concentrations of most individual PFAS and isomer profiles of PFOS and PFOA. Men generally exhibited higher plasma concentrations than their partners, likely reflecting gender-specific elimination pathway and kinetics. Couple-based PFAS exposure also varied greatly. After adjustment for individual factors, several household factors, including annual household income, dwelling floor type, drinking water source, and living near farmlands, were found to be associated with couple-based PFAS exposure. Our study constitutes one of the few studies addressing couple-based exposure to PFAS and lays a solid ground for further assessment of the impacts of parental exposure on reproductive health.

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“…Exposure to EDCs, including phthalates and parabens, has been associated with increased risk of preterm birth [ 3 , 6 – 10 ]. Racial/ethnic differences in exposure to these chemicals have been observed, with non-Hispanic Black pregnant and non-pregnant women having higher concentrations of some EDCs, including certain phthalates and parabens, compared to non-Hispanic White women in the U.S. [ 11 – 14 ].…”

Section: Introductionmentioning

confidence: 99%

Endocrine disrupting chemical-associated hair product use during pregnancy and gestational age at delivery: a pilot study

et al. 2021

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Background Prenatal endocrine disrupting chemical (EDC) exposure has been associated with increased risk of preterm birth. Non-Hispanic Black women have higher incidence of preterm birth compared to other racial/ethnic groups and may be disproportionately exposed to EDCs through EDC-containing hair products. However, research on the use of EDC-associated hair products during pregnancy and risk of preterm birth is lacking. Therefore, the objective of this pilot study was to estimate associations of prenatal hair product use with gestational age at delivery in a Boston, Massachusetts area pregnancy cohort. Methods The study population consisted of a subset of participants enrolled in the Environmental Reproductive and Glucose Outcomes (ERGO) Study between 2018 and 2020. We collected self-reported data on demographics and hair product use using a previously validated questionnaire at four prenatal visits (median: 12, 19, 26, 36 weeks’ gestation) and abstracted gestational age at delivery from medical records. We compared gestational age and hair product use by race/ethnicity and used linear regression to estimate covariate-adjusted associations of product use and frequency of use at each study visit with gestational age at delivery. Primary models were adjusted for maternal age at enrollment and delivery method. Results Of the 154 study participants, 7% delivered preterm. Non-Hispanic Black participants had lower mean gestational age at delivery compared to non-Hispanic White participants (38.2 vs. 39.2 weeks) and were more likely to report ever and more frequent use of hair products. In regression models, participants reporting daily use of hair oils at visit 4 had lower mean gestational age at delivery compared to non-users (β: -8.3 days; 95% confidence interval: -14.9, -1.6). We did not find evidence of associations at earlier visits or with other products. Conclusions Frequent use of hair oils during late pregnancy may be associated with shorter gestational duration. As hair oils are more commonly used by non-Hispanic Black women and represent potentially modifiable EDC exposure sources, this may have important implications for the known racial disparity in preterm birth.

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Parental preconception exposure to phenol and phthalate mixtures and the risk of preterm birth

Cited by 47 publications

References 104 publications

Joint effects of prenatal household air pollution exposure from multiple sources on preterm birth - A case-control study with propensity score matching

Joint effects of prenatal household air pollution exposure from multiple sources on preterm birth - A case-control study with propensity score matching

Exposure of Preconception Couples to Legacy and Emerging Per- and Polyfluoroalkyl Substances: Variations Within and Between Couples

Endocrine disrupting chemical-associated hair product use during pregnancy and gestational age at delivery: a pilot study

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