Parental perception of their child's quality of life in children with non‐immunoglobulin‐E‐mediated gastrointestinal allergies

Foong, Ru-Xin; Godwin, Heather; Dziubak, Robert; Lozinsky, Adriana Chebar; Reeve, Kate; Knibb, Rebecca; Shah, Neil

doi:10.1111/pai.12689

Cited by 11 publications

(8 citation statements)

References 27 publications

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“…More recently, Foong et al compared QoL in children with non–IgE‐mediated gastrointestinal food allergy, children with IgE‐mediated food allergy and children with functional abdominal pain. Parents completed the PedsQL and the Family Impact module.…”

Section: What Is the Quality Of Life Of Mothers On An Elimination Diementioning

confidence: 99%

Diagnosis and management of Non‐IgE gastrointestinal allergies in breastfed infants—An EAACI Position Paper

Meyer

Lozinsky

Fleischer

et al. 2019

Allergy

102

119

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It is well-established that food proteins, such as egg, soya, cow's milk and wheat, are detectable in breastmilk for many hours or days after ingestion. Exposure to these proteins is important to the process of developing tolerance but can also sometimes elicit IgE-mediated and non-IgE-mediated allergic symptoms in breastfed infants. Non-IgEmediated allergy, outside of food protein-induced allergic proctocolitis and eosinophilic oesophagitis, is not well understood, leading to variations in the diagnosis and management thereof. A primary objective of the European Academy for Allergy and Clinical Immunology is to support breastfeeding in all infants, including those with food allergies. A Task Force was established, to explore the clinical spectrum of non-IgE-mediated allergies, and part of its objectives was to establish diagnosis and management of non-IgE-mediated allergies in breastfed infants. Eight questions were formulated using the Patient, Intervention, Comparison, Outcome (PICO) system and Scottish Intercollegiate | 15 MEYER Et al. Highlights MEYER Et al. consultancy in the past for AbbVie. CV gives academic lectures for Mead Johnson, Abbot, Danone/Nutricia and Nestle; and received research support from Thermo Fisher. AUTH O R CO NTR I B UTI O N S RM involved in the literature review, writing of sections in article, Delphi consensus, merging of article sections and final submission. ACL involved in the literature review, writing of sections in article, Delphi consensus and critical review of publication. CD, RK, ANW, GdT, DF, YV, MCV, OC, PU and NS involved in writing of sections in article, Delphi consensus and critical review of publication. CV involved in the literature review, writing of sections in article, Delphi consensus and critical review of publication.

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Section: What Is the Quality Of Life Of Mothers On An Elimination Diementioning

confidence: 99%

Diagnosis and management of Non‐IgE gastrointestinal allergies in breastfed infants—An EAACI Position Paper

Meyer

Lozinsky

Fleischer

et al. 2019

Allergy

102

119

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show abstract

“…Seeing blood in stool may be very worrisome for a mother. In a study which found poorer physical QoL in non-IgE-mediated FA than that in IgE-mediated, the authors concluded that extra manifestations such as pain, hypermobility and fatigue and delays in diagnosis due to absence of laboratory tests may had an impact on the emotional psychological health of children (30). In another study, poor physical and emotional functioning associated with non-IgE-mediated FA was thought to be related with poor symptom recognition, delay in diagnosis and noxious symptoms such as sleep deprivation due to abdominal pain and feeding difficulties (31).…”

Section: Discussionmentioning

confidence: 99%

Negative effect of dietary elimination on breastfeeding mothers having infants with and without food allergy

Yılmaz¹,

As²,

Gogebakan³

et al. 2021

Preprint

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Background: There has been no trial evaluating the psychopathology in breastfeeding mothers of infants with food allergy (FA). Objective: To investigate the effect of dietary elimination on maternal psychopathology, specifically stress/anxiety and mother-to-infant bonding and explore the importance of sociodemographic features on these variables. Methods: Breastfeeding mothers following an elimination diet due to FA in their children aged 1-to-12 months were compared with the healthy controls. Physician-diagnosed FA group were divided into IgE-, non-IgE-mediated and infants with some minor symptoms which were not enough to make the diagnosis of FA were classified as Indecisive symptoms for FA group. Mothers completed standardized questionnaires including Symptom Checklist 90R, Beck Depression/Anxiety Inventories (BDI/BAI), Postpartum Bonding Questionnaire (Bonding). Results: Of 179 mother-infants, 64 were healthy, 89 were FA, 16 were indecisive symptoms for FA. The mean age of the mothers and infants were 31.1±4.7 years and 6.3±3.6 months. The physician diagnosed FA groups had higher scores for anxiety (p=0.008), anger (p=0.042), depression (p<0.001), obsession (p=0.002), phobia (p=0.008), somatization (p=0.002) and general symptom index (GSI) (p=0.001), BDI (p<0.001), BAI (p=0.008) and Bonding [attachment (p=0.001), anger (p=0.019) and total (p=0.036)] than the healthy. The indecisive symptoms for FA group had a similar score pattern to physician-diagnosed FA except interpersonal sensitivity, BDI and attachment. Conclusion: Breastfeeding mothers of infants with FA were anxious, depressive and had many psychopathologies which affected bonding. Interventions targeting negativity in caregivers’ social relationships are urgently needed.

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“…While the impact of IgE-mediated food allergies on quality of life (QoL) has long been established, the effect of non-IgE-GI-FA has only been recently studied. Strikingly, one cross-sectional study of 52 children with non-IgE-GI-FA reported lower physical QoL scores compared to children with IgE-FA [177]. Similarly, another prospective observational study of 123 children with non-IgE-GI-FA revealed inferior QoL scores in all evaluated domains compared to children with sickle cell anemia, including spheres of physical functioning, emotional functioning, and worry [178].…”

Section: Quality Of Lifementioning

confidence: 98%

Non-IgE-Mediated Gastrointestinal Food Allergies in Children: An Update

2020

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Non-immunoglobulin E-mediated gastrointestinal food allergic disorders (non-IgE-GI-FA) include food protein-induced enterocolitis syndrome (FPIES), food protein-induced enteropathy (FPE) and food protein-induced allergic proctocolitis (FPIAP), which present with symptoms of variable severity, affecting the gastrointestinal tract in response to specific dietary antigens. The diagnosis of non-IgE-GI-FA is made clinically, and relies on a constellation of typical symptoms that improve upon removal of the culprit food. When possible, food reintroduction should be attempted, with the documentation of symptoms relapse to establish a conclusive diagnosis. Management includes dietary avoidance, nutritional counselling, and supportive measures in the case of accidental exposure. The prognosis is generally favorable, with the majority of cases resolved before school age. Serial follow-up to establish whether the acquisition of tolerance has occurred is therefore essential in order to avoid unnecessary food restriction and potential consequent nutritional deficiencies. The purpose of this review is to delineate the distinctive clinical features of non-IgE-mediated food allergies presenting with gastrointestinal symptomatology, to summarize our current understanding of the pathogenesis driving these diseases, to discuss recent findings, and to address currents gaps in the knowledge, to guide future management opportunities.

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Parental perception of their child's quality of life in children with non‐immunoglobulin‐E‐mediated gastrointestinal allergies

Abstract: This study has shown that different areas of HRQoL of children with GIFA are affected compared with children with FAP or IgE-mediated food allergy, highlighting the need for a specific GIFA HRQoL questionnaire to better understand the impact on these children.

Cited by 11 publications

References 27 publications

Diagnosis and management of Non‐IgE gastrointestinal allergies in breastfed infants—An EAACI Position Paper

Diagnosis and management of Non‐IgE gastrointestinal allergies in breastfed infants—An EAACI Position Paper

Negative effect of dietary elimination on breastfeeding mothers having infants with and without food allergy

Non-IgE-Mediated Gastrointestinal Food Allergies in Children: An Update

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