Parental occupational exposure and risk of childhood central nervous system tumors: a pooled analysis of case–control studies from Germany, France, and the UK

Huoi, Catherine; Olsson, Ann; Lightfoot, Tracy; Roman, Eve; Clavel, Jacqueline; Lacour, Brigitte; Kaatsch, Peter; Kromhout, Hans; Vermeulen, Roel; Peters, Susan; Bailey, Helen D.; Schüz, Joachim

doi:10.1007/s10552-014-0465-4

Cited by 11 publications

(8 citation statements)

References 27 publications

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“…A similar conclusion can be reached for parental occupational exposure or for the exposure to different possible environmental factors [34][35][36][37].…”

Section: Risk Factorssupporting

confidence: 68%

Central Nervous System Congenital Tumors

et al. 2019

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“…A similar conclusion can be reached for parental occupational exposure or for the exposure to different possible environmental factors [34][35][36][37].…”

Section: Risk Factorssupporting

confidence: 68%

Central Nervous System Congenital Tumors

et al. 2019

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“…Estimations were performed using the general population DOM-JEM. [18][19][20] The DOM-JEM is based on the five-digit ISCO 1968 coding, 17 providing an exposure estimate (none, low, high) to each individual job code.…”

Section: Classification Of Occupational Exposuresmentioning

confidence: 99%

Multicentre, population-based, case–control study of particulates, combustion products and amyotrophic lateral sclerosis risk

Visser

D’Ovidio

Peters

et al. 2019

J Neurol Neurosurg Psychiatry

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Objective To investigate whether exposure to particulates and combustion products may explain the association between certain occupations and amyotrophic lateral sclerosis (aLs) risk in a large, multicentre, population-based, case-control study, based on full job histories, using job-exposure matrices, with detailed information on possible confounders. Methods population-based patients with aLs and controls were recruited from five registries in the Netherlands, Ireland and Italy. Demographics and data regarding educational level, smoking, alcohol habits and lifetime occupational history were obtained using a validated questionnaire. Using job-exposure matrices, we assessed occupational exposure to silica, asbestos, organic dust, contact with animals or fresh animal products, endotoxins, polycyclic aromatic hydrocarbons and diesel motor exhaust. Multivariate logistic regression models adjusting for confounding factors were used to determine the association between these exposures and aLs risk. results We included 1557 patients and 2922 controls. associations were positive for all seven occupational exposures (ORs ranging from 1.13 to 1.73 for high vs never exposed), and significant on the continuous scale for silica, organic dust and diesel motor exhaust (p values for trend ≤0.03). additional analyses, adding an exposure (one at a time) to the model in the single exposure analysis, revealed a stable OR for silica. We found similar results when patients with a C9orf72 mutation were excluded. Conclusion In a large, multicentre study, using harmonised methodology to objectively quantify occupational exposure to particulates and combustion products, we found an association between aLs risk and exposure to silica, independent of the other occupational exposures studied.

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“… 15 These results were not replicated, however, in a pooled analysis of several European case–control studies with self-reported information on parental occupation, which found no association between maternal exposure to diesel EEF and CNS tumors. 16 …”

Section: Discussionmentioning

confidence: 99%

“…A recent Danish register–based study indicated that maternal occupational exposure to diesel EEFs led to higher risks of astrocytoma but not leukemia in the child. 15 However, previous studies based on self-reports of occupation or EEF exposure found no elevated risk for CNS tumors 16 but did find increased risks of ALL from parental, 17 paternal, 11 , 18 or maternal exposure. 11 , 19 Children whose fathers were exposed to gasoline EEF also appeared to be at risk of non-Hodgkin lymphoma in one study.…”

Section: Introductionmentioning

confidence: 86%

Risk of Cancer in Children of Parents Occupationally Exposed to Hydrocarbon Solvents and Engine Exhaust Fumes: A Register-Based Nested Case–Control Study from Sweden (1960–2015)

Rossides

Kampitsi

Talbäck

et al. 2022

Environ Health Perspect

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Background: It remains unclear whether parental occupational exposure to hydrocarbon solvents (HCS) or engine exhaust fumes (EEF) is associated with higher risks of cancer in the offspring. Objectives: Our aim was to estimate relative risks of childhood cancers associated with maternal or paternal exposure to aliphatic/alicyclic, aromatic, or chlorinated HCS or gasoline/diesel EEF. Methods: We conducted a case–control study in which individuals old, born 1960–2014, were identified from the Swedish National Cancer Register (1960–2015) at first cancer diagnosis and matched to population controls (1 case:25 controls) on birth year and sex. Maternal and paternal occupation around the child’s birth was retrieved for 9,653 cases and 172,194 controls and 12,521 cases and 274,434 controls, respectively, using information from six censuses and a nationwide register. Using the Swedish job-exposure matrix (SWEJEM), we assessed exposure to HCS and EEF (any or higher/lower). Odds ratios (ORs) and 95% confidence intervals (CIs) of 15 childhood cancer subtypes were estimated using conditional logistic regression models adjusted for several confounders. Results: Maternal exposure to aromatic HCS was associated with non-Hodgkin lymphoma ( ; 95% CI: 1.05, 2.58), aliphatic/alicyclic HCS with germ cell tumors ( ; 95% CI: 0.89, 2.59), and gasoline/diesel EEF with astrocytoma ( ; 95% CI: 1.04, 1.88), myeloid leukemia ( ; 95% CI: 0.84, 2.81), lymphomas ( ; 95% CI: 0.85, 3.02 for Hodgkin; ; 95% CI: 0.71, 2.91 for non-Hodgkin), and epithelial tumors ( ; 95% CI: 0.93, 2.44). Paternal exposure to gasoline EEF was associated with Hodgkin lymphoma ( ; 95% CI: 1.01, 1.44) and soft tissue sarcomas ( ; 95% CI: 1.00, 1.48). No notable difference was observed between higher and lower exposure. Discussion: Our findings suggest that occupational exposure to HCS or EEF, especially in the mother, may increase the risk of some childhood cancers. They add to the growing literature on adverse effects from HCS and EEF in the child, but replication of these associations in other populations is warranted. https://doi.org/10.1289/EHP11035

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Parental occupational exposure and risk of childhood central nervous system tumors: a pooled analysis of case–control studies from Germany, France, and the UK

Abstract: Our large pooled study showed weak evidence of a modest association between paternal occupational exposure to PAH and CNS tumor risk. Our findings need further exploration in the future studies.

Cited by 11 publications

References 27 publications

Central Nervous System Congenital Tumors

Central Nervous System Congenital Tumors

Multicentre, population-based, case–control study of particulates, combustion products and amyotrophic lateral sclerosis risk

Risk of Cancer in Children of Parents Occupationally Exposed to Hydrocarbon Solvents and Engine Exhaust Fumes: A Register-Based Nested Case–Control Study from Sweden (1960–2015)

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