Parental history of type 2 diabetes, TCF7L2 variant and lower insulin secretion are associated with incident hypertension. Data from the DESIR and RISC cohorts

Abstract

Aims/hypothesis The relationship between insulin secretion and the incidence of hypertension has not been well characterised. We hypothesised that both a parental history of diabetes and TCF7L2 rs7903146 polymorphism, which increases susceptibility to diabetes because of impaired beta cell function, are associated with incident hypertension. In a separate cohort, we assessed whether low insulin secretion is related to incident hypertension. Methods Nine year incident hypertension was studied in 2,391 normotensive participants from the Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort. The relationship between insulin secretion and 3 year incident hypertension was investigated in 1,047 non-diabetic, normotensive individuals from the Relationship between Insulin Sensitivity and Cardiovascular Disease (RISC) cohort. Insulin secretion during OGTT was expressed in relation to the degree of insulin resistance, as assessed by a hyperinsulinaemic-euglycaemic clamp. Results In the DESIR cohort, a parental history of diabetes and the TCF7L2 at-risk variant were both associated with hypertension incidence at year 9, independently of waist circumference, BP, fasting glucose, insulin levels and HOMA-IR at inclusion (p=0.02 for parental history, p=0.006 for Members of the DESIR Study Group and the RISC investigators are listed in the electronic supplementary material (ESM).Electronic supplementary material The online version of this article (doi:10.1007/s00125-013-3021-y) contains peer-reviewed but unedited supplementary material, which is available to authorised users.

The Association of Type 2 Diabetes Loci Identified in Genome-Wide Association Studies with Metabolic Syndrome and Its Components in a Chinese Population with Type 2 Diabetes

“…On the other hand, the pleotropic effects of T allele on the factors promoting MetS or preventing MetS could partly explain the negative findings in previous studies [ 14 , 61 , 62 , 63 ]. In addition, a study reported that the T allele was the risk factor for incident hypertension [ 64 ] or increased TG level in elderly population [ 22 ], which was inconsistent with the present findings. However, the inconsistency could be partly explained by the different study design and population, as both the phenotypes were closely connection to blood glucose.…”

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“…Taken as a whole, it seems unlikely that our results may be explained solely by the effect of reduced insulin secretion on inflammation. We described in the RISC study a link between insulin secretion and the risk of development of hypertension, which is another potential confounder in the current analysis [29].…”

Low fasting plasma insulin is associated with atrial fibrillation in men from a cohort study - the Malmö preventive project

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