Parental factors that impact the ecology of human mammary development, milk secretion, and milk composition—a report from “Breastmilk Ecology: Genesis of Infant Nutrition (BEGIN)” Working Group 1

Neville, Margaret C.; Demerath, Ellen W.; Hahn‐Holbrook, Jennifer; Hovey, Russell C.; Martin-Carli, Jayne Frances; McGuire, Mark A.; Newton, Edward R.; Rasmussen, Kathleen M.; Rudolph, Michael C.; Raiten, Daniel J.

doi:10.1016/j.ajcnut.2022.11.026

Cited by 19 publications

(38 citation statements)

References 198 publications

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“…Recently, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) of the National Institutes of Health (NIH) initiated the “Breastmilk Ecology: Genesis of Infant Nutrition (BEGIN)” Project ( Raiten et al, 2023 ), which convened leaders in the field of lactation science to “explore factors influencing the synthesis, composition, and best use of human milk.” The BEGIN working groups conceptualized new approaches toward understanding human milk as a complex biological system ( Donovan et al, 2023 ; Krebs et al, 2023 ; Neville et al, 2023 ; Nommsen-Rivers et al, 2023 ; Smilowitz et al, 2023 ). Indeed, milk fat secretion is thought to be influenced by myriad factors within the context of the mother-milk-infant triad.…”

Section: Discussionmentioning

confidence: 99%

Comparative proteomic analysis of human milk fat globules and paired membranes and mouse milk fat globules identifies core cellular systems contributing to mammary lipid trafficking and secretion

Martin Carli,

Dzieciatkowska,

Hernandez

et al. 2023

Front. Mol. Biosci.

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Introduction: Human milk delivers critical nutritional and immunological support to human infants. Milk fat globules (MFGs) and their associated membranes (MFGMs) contain the majority of milk lipids and many bioactive components that contribute to neonatal development and health, yet their compositions have not been fully defined, and the mechanisms responsible for formation of these structures remain incompletely understood.Methods: In this study, we used untargeted mass spectrometry to quantitatively profile the protein compositions of freshly obtained MFGs and their paired, physically separated MFGM fractions from 13 human milk samples. We also quantitatively profiled the MFG protein compositions of 9 pooled milk samples from 18 lactating mouse dams.Results: We identified 2,453 proteins and 2,795 proteins in the majority of human MFG and MFGM samples, respectively, and 1,577 proteins in mouse MFGs. Using paired analyses of protein abundance in MFGMs compared to MFGs (MFGM-MFG; 1% FDR), we identified 699 proteins that were more highly abundant in MFGMs (MFGM-enriched), and 201 proteins that were less abundant in MFGMs (cytoplasmic). MFGM-enriched proteins comprised membrane systems (apical plasma membrane and multiple vesicular membranes) hypothesized to be responsible for lipid and protein secretion and components of membrane transport and signaling systems. Cytoplasmic proteins included ribosomal and proteasomal systems. Comparing abundance between human and mouse MFGs, we found a positive correlation (R2 = 0.44, p < 0.0001) in the relative abundances of 1,279 proteins that were found in common across species.Discussion: Comparative pathway enrichment analyses between human and mouse samples reveal similarities in membrane trafficking and signaling pathways involved in milk fat secretion and identify potentially novel immunological components of MFGs. Our results advance knowledge of the composition and relative quantities of proteins in human and mouse MFGs in greater detail, provide a quantitative profile of specifically enriched human MFGM proteins, and identify core cellular systems involved in milk lipid secretion.

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Section: Discussionmentioning

confidence: 99%

Comparative proteomic analysis of human milk fat globules and paired membranes and mouse milk fat globules identifies core cellular systems contributing to mammary lipid trafficking and secretion

Martin Carli,

Dzieciatkowska,

Hernandez

et al. 2023

Front. Mol. Biosci.

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“…In addition, maternal psychological distress may lead to greater levels of cortisol and lower insulin sensitivity, which are both related to decreased milk production (Nagel et al, 2022). Future work is needed to better understand how prenatal and early postnatal depression may affect lactation and milk composition to test whether these physiological changes may be another pathway by which prenatal depression may influence offspring cardiometabolic risk (Neville et al, 2023).…”

Section: Evidence For Biological and Behavioral Pathwaysmentioning

confidence: 99%

“…Mothers with higher postnatal depressive symptoms are less likely to ever breastfeed (Neville et al, 2023), more likely to discontinue breastfeeding early, and more likely to report difficulties with breastfeeding (Dennis & McQueen, 2007; McLearn et al, 2006). A large meta-analysis demonstrated that breastfeeding is directly related to lower child BMI and obesity risk (Yan et al, 2014).…”

Section: Behavioral Pathwaysmentioning

confidence: 99%

Biological and behavioral pathways from prenatal depression to offspring cardiometabolic risk: Testing the developmental origins of health and disease hypothesis.

Doom,

Deer,

Dabelea

et al. 2024

Developmental Psychology

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Given prior literature focused on the Developmental Origins of Health and Disease framework, there is strong rationale to hypothesize that reducing depression in the prenatal period will cause improvements in offspring cardiometabolic health. The current review outlines evidence that prenatal depression is associated with offspring cardiometabolic risk and health behaviors. We review evidence of these associations in humans and in nonhuman animals at multiple developmental periods, from the prenatal period (maternal preeclampsia, gestational diabetes), neonatal period (preterm birth, small size at birth), infancy (rapid weight gain), childhood and adolescence (high blood pressure, impaired glucose–insulin homeostasis, unfavorable lipid profiles, abdominal obesity), and into adulthood (diabetes, cardiovascular disease). In addition to these cardiometabolic outcomes, we focus on health behaviors associated with cardiometabolic risk, such as child eating behaviors, diet, physical activity, and sleep health. Our review focuses on child behaviors (e.g., emotional eating, preference for highly palatable foods, short sleep duration) and parenting behaviors (e.g., pressuring child to eat, modeling of health behaviors). These changes in health behaviors may be detected before changes to cardiometabolic outcomes, which may allow for early identification of and prevention for children at risk for poor adult cardiometabolic outcomes. We also discuss the methods of the ongoing Care Project, which is a randomized clinical trial to test whether reducing prenatal maternal depression improves offspring’s cardiometabolic health and health behaviors in preschool. The goal of this review and the Care Project are to inform future research, interventions, and policies that support prenatal mental health and offspring cardiometabolic health.

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“…The most recent national Canadian data indicate that while 91% of infants initiated breastfeeding, only 35% exclusively breastfed to six months ( 10 ). As in other high-income countries, there are social disparities in breastfeeding as this behavior is negatively impacted by the social and structural determinants of health, including HFI ( 11 – 13 ). For instance, secondary data analysis from multiple cycles of the nationally representative, cross-sectional Canadian Community Health Survey found no difference in breastfeeding initiation based on HFI status, but respondents with HFI had lower odds of breastfeeding exclusively to four months ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

Household food insecurity is negatively associated with achievement of prenatal intentions to feed only breast milk in the first six months postpartum

Francis,

Mildon,

Tarasuk

et al. 2024

Front. Nutr.

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BackgroundHousehold food insecurity (HFI) has been associated with suboptimal breastfeeding practices. Postpartum factors reported by caregivers include stressful life circumstances and maternal diet quality concerns. It is unknown whether prenatal breast milk feeding intentions, a well-established predictor of breastfeeding outcomes, differ by HFI status. We explored associations between HFI and prenatal intentions to feed any and only breast milk in the first 6 months postpartum, and achievement of these intentions.MethodsWe utilized data from self-identified biological mothers with children 6–12 months of age who responded to a retrospective, cross-sectional online infant feeding survey conducted in Nova Scotia, Canada. HFI (yes/no) was assessed using the Household Food Security Survey Module. Prenatal intentions to feed any and only breast milk were assessed based on responses to five options for infant milk feeding plans. Achievement of intentions was assessed by breast milk and formula feeding practices in the first 6 months. Multivariable logistic regressions were conducted, adjusting for maternal socio-demographics.ResultsAmong 459 respondents, 28% reported HFI; 88% intended to feed any breast milk and 77% intended to feed only breast milk, with no difference by HFI status. Of those intending to feed any breast milk, 99% succeeded, precluding further analysis. Among mothers who intended to provide only breast milk, only 51% achieved their intention, with lower odds among those with HFI (aOR 0.54, 95% CI 0.29–0.98).ConclusionHFI was not associated with intentions for feeding breast milk in the first 6 months postpartum, but mothers with HFI were less likely to achieve their intention to provide only breast milk. Further research is needed to understand the underlying reasons for this and to guide intervention designs to address HFI and help mothers reach their breastfeeding goals.

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Parental factors that impact the ecology of human mammary development, milk secretion, and milk composition—a report from “Breastmilk Ecology: Genesis of Infant Nutrition (BEGIN)” Working Group 1

Cited by 19 publications

References 198 publications

Comparative proteomic analysis of human milk fat globules and paired membranes and mouse milk fat globules identifies core cellular systems contributing to mammary lipid trafficking and secretion

Comparative proteomic analysis of human milk fat globules and paired membranes and mouse milk fat globules identifies core cellular systems contributing to mammary lipid trafficking and secretion

Biological and behavioral pathways from prenatal depression to offspring cardiometabolic risk: Testing the developmental origins of health and disease hypothesis.

Household food insecurity is negatively associated with achievement of prenatal intentions to feed only breast milk in the first six months postpartum

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